Animate models of human head injury

Gennarelli, Thomas A.

Affiliations

¹Division of Neurosurgery, Head Injury Center, University of Pennsylvania, Philadelphia, Pennsylvania

Abstract

A review of animal models of nonpenetrating head injury caused by mechanical energy is presented that focuses on the ability of various categories of models and their relationships to the types of head injury seen in humans. Basic hypotheses of animal modeling of human disease and outcome measures are addressed. Current models are reviewed and compared for their differences and similarities regarding behavioral, pathologic, physiologic, and biochemical fidelity to human head injury.

Links

DOI: 10.1089/neu.1994.11.357

PubMed: 7837277

WoS: A1994PG28900002

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Cited By (19)

Year	Entry
1999	Margulies SS, Meaney DF, Smith D, Chen X-H, Miller R, Raghupathi R. A comparison of diffuse brain injury in the newborn and adult pig. In: Proceedings of the 1999 International IRCOBI Conference on the Biomechanics of Impact. September 23-24, 1999; Sitges, Spain.133-145.
2005	LaPlaca MC, Cullen DK, McLoughlin JJ, Cargill RS II. High rate shear strain of three-dimensional neural cell cultures: a new in vitro traumatic brain injury model. J Biomech. May 2005;38(5):1093-1105.
1995	Povlishock JT, Christman CW. Traumatically induced axonal injury in animals and humans: a review of current thoughts. J Neurotrauma. June 1995;12(3):555-564.
2003	Gefen A, Gefen N, Zhu Q, Raghupathi R, Margulies SS. Age-dependent changes in material properties of the brain and braincase of the rat. J Neurotrauma. November 2003;20(11):1163-1177.
2006	Geddes-Klein DM, Schiffman KB, Meaney DF. Mechanisms and consequences of neuronal stretch injury in vitro differ with the model of trauma. J Neurotrauma. February 2006;23(2):193-204.
2005	Cullen DK. Traumatically-Induced Degeneration and Reactive Astrogliosis in Three-Dimensional Neural Co-Cultures: Factors Influencing Neural Stem Cell Survival and Integration [PhD thesis]. Atlanta, GA: Georgia Institute of Technology; December 2005.
2008	Lessing MC. The Acute Cellular and Behavioral Response to Mechanical Neuronal Injury [PhD thesis]. Atlanta, GA: Georgia Institute of Technology; December 2008.
2012	Oeur A. An Analysis of Head Impact Angle on the Dynamic Response of a Hybrid III Headform and Brain Tissue Deformation [Master's thesis]. Ottawa, ON: University of Ottawa; December 2012.
2018	Oeur RA. The Effects of Reconstructed Head Impact Event Parameters on Risk of Sport Related Concussions [PhD thesis]. Ottawa, ON: University of Ottawa; 2018.
2019	Karton C. Profiling Brain Trauma in Professional American-Style Football and the Implications to Developing Neurological Injury [PhD thesis]. Ottawa, ON: University of Ottawa; 2019.
1998	Bain AC. In Vivo Mechanical Thresholds for Morphological and Functional Axonal Injury [PhD thesis]. Philadelphia, PA: University of Pennsylvania; 1998.
1998	Shreiber DI. Experimental and Computational Modeling of Traumatic Brain Injury: In Vivo Thresholds for Mechanical Disruption of the Blood-Brain Barrier [PhD thesis]. Philadelphia, PA: University of Pennsylvania; 1998.
1999	Morrison B III. Differential Genomic Expression After Mechanical Injury of Organotypic Brain Slice Cultures: An in Vitro Model of Traumatic Brain Injury [PhD thesis]. Philadelphia, PA: University of Pennsylvania; 1999.
2002	Lusardi TAG. Initiation and Propagation of Mechanically Induced Neuronal Injury [PhD thesis]. Philadelphia, PA: University of Pennsylvania; 2002.
2005	DeRidder MN. The Role of Cell Kinematics and the N-Methyl D-Aspartate Receptor in Apoptosis and Necrosis in the in Vitro Hippocampus Following Mechanical Injury [PhD thesis]. Philadelphia, PA: University of Pennsylvania; 2005.
2011	Mesfin MN. Phosphorylation-Mediated Signaling After Mechanical Neuronal Injury: An Investigation of Striatal Enriched Tyrosine Phosphatase and Elk-1 [PhD thesis]. Philadelphia, PA: University of Pennsylvania; 2011.
2014	Chen Y. Astrocyte Signaling in Traumatic Brain Injury [PhD thesis]. Philadelphia, PA: University of Pennsylvania; 2014.
2018	Atlan LS. Direction-Dependent Responses to Traumatic Brain Injury in Pediatric Pigs [PhD thesis]. Philadelphia, PA: University of Pennsylvania; 2018.
2020	Zhou R. Development of Rat Head Finite Element Model and Tissue Level Biomechanical Threshold for Traumatic Axonal Injury [PhD thesis]. Detroit, MI: Wayne State University; May 2020.