The use of nanoindentation for characterizing the properties of mineralized hard tissues:​ state-of-the art review

Lewis, Gladius; Nyman, Jeffry S.

Affiliations

¹Department of Mechanical Engineering, The University of Memphis, Memphis, Tennessee 38152

²Vanderbilt Center for Bone Biology and Department of Orthopaedics and Rehabilitation, Vanderbilt University, Nashville, Tennessee 37232

Abstract and keywords

The use of nanoindentation to determine nanomechanical properties of mineralized tissues has been investigated extensively. A detailed, critical, and comprehensive review of this literature is the subject of the present work. After stating the motivation for the review, a succinct presentation of the challenges, advantages, and disadvantages of the various quasi-static nanoindentation test methods (to obtain elastic modulus, E, and hardness, H) and dynamic test methods (to obtain storage and loss moduli and/or loss/damping factor) is given in the form of a primer. Explicative summaries of literature reports on various intrinsic and extrinsic factors that significantly influence E and H, followed by 15 suggested topics for future research, are included additionally. This review is designed to present a compact guide to the principles of the nanoindentation technique and to emphasize considerations when determining material properties of mineralized tissues.

Keywords: nanoindentation; bone; teeth; stiffness; hardness

Links

DOI: 10.1002/jbm.b.31092

PubMed: 18395829

WoS: 000259328900035

History

Received: 2007-08-02

Revised: 2008-01-20

Accepted: 2008-01-25

Online: 2008-04-07

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