Canonical Wnt/β-catenin signaling prevents osteoblasts from differentiating into chondrocytes

Hill, Theo P.; Später, Daniela; Taketo, Makoto M.; Birchmeier, Walter; Hartmann, Christine

Affiliations

¹Research Institute for Molecular Pathology, Dr Bohr-Gasse 7, A-1030 Vienna, Austria

²Department of Pharmacology, Graduate School of Medicine, Kyoto University, Yoshida-Konoe-cho, Sakyo-ku Kyoto, 606-8501, Japan

³Max-Delbrück Center for Molecular Medicine, Robert-Roessle-Strasse 10, 13125 Berlin, Germany

Links

DOI: 10.1016/j.devcel.2005.02.013

PubMed: 15866163

WoS: 000229103000012

History

Received: 2004-12-6

Revised: 2005-01-28

Accepted: 2005-02-8

Online: 2005-05-2

Cited Works (11)

Year	Entry
2002	Karsenty G, Wagner EF. Reaching a genetic and molecular understanding of skeletal development. Dev Cell. April 2002;2(4):389-406.
2002	Akiyama H, Chaboissier M-C, Martin JF, Schedl A, de Crombrugghe B. The transcription factor Sox9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for expression of Sox5 and Sox6. Genes Dev. November 1, 2002;16(21):2813-2828.
2001	Gong Y, Slee RB, Fukai N, Rawadi G, Roman-Roman S, Reginato AM, Wang H, Cundy T, Glorieux FH, Lev D, Zacharin M, Oexle K, Marcelino J, Suwairi W, Heeger S, Sabatakos G, Apte S, Adkins WN, Allgrove J, Arslan-Kirchner M, Batch JA, Beighton P, Black GCM, Boles RG, Boon LM, Borrone C, Brunner HG, Carle GF, Dallapiccola B, De Paepe A, Floege B, Halfhide ML, Hall B, Hennekam RC, Hirose T, Jans A, Jüppner H, Kim CA, Keppler-Noreuil K, Kohlschuetter A, LaCombe D, Lambert M, Lemyre E, Letteboer T, Peltonen L, Ramesar RS, Romanengo M, Somer H, Steichen-Gersdorf E, Steinmann B, Sullivan B, Superti-Furga A, Swoboda W, van den Boogaard M-J, Van Hul W, Vikkula M, Votruba M, Zabel B, Garcia T, Baron R, Olsen BR, Warman ML. LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development. Cell. November 16, 2001;107(4):513-523.
1999	Bi W, Deng JM, Zhang Z, Behringer RR, de Crombrugghe B. Sox9 is required for cartilage formation. Nat Genet. May 1999;22(1):85-89.
2005	Glass DA II, Bialek P, Ahn JD, Starbuck M, Patel MS, Clevers H, Taketo MM, Long F, McMahon AP, Lang RA, Karsenty G. Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation. Dev Cell. May 2005;8(5):751-764.
1997	Otto F, Thornell AP, Crompton T, Denzel A, Gilmour KC, Rosewell IR, Stamp GW, Beddington RS, Mundlos S, Olsen BR, Selby PB, Owen MJ. Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development. Cell. May 30, 1997;89(5):765-771.
2002	Nakashima K, Zhou X, Kunkel G, Zhang Z, Deng JM, Behringer RR, de Crombrugghe B. The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation. Cell. January 11, 2002;108(1):17-29.
1997	Komori T, Yagi H, Nomura S, Yamaguchi A, Sasaki K, Deguchi K, Shimizu Y, Bronson RT, Gao Y-H, Inada M, Sato M, Okamoto R, Kitamura Y, Yoshiki S, Kishimoto T. Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts. Cell. May 30, 1997;89(5):755-764.
2003	Kronenberg HM. Developmental regulation of the growth plate. Nature. May 15, 2003;423(6937):332-336.
1999	St-Jacques B, Hammerschmidt M, McMahon AP. Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation. Genes Dev. August 15, 1999;13(16):2072-2086.
1978	McKibbin B. The biology of fracture healing in long bones. J Bone Joint Surg. May 1978;60B(2):150-162.

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2008	Boyce BF, Xing L. Functions of RANKL/RANK/OPG in bone modeling and remodeling. Arch Biochem Biophys. May 15, 2008;473(2):139-146.
2012	Marsell R, Sisask G, Nilsson Y, Sundgren-Andersson AK, Andersson U, Larsson S, Nilsson O, Ljunggren Ö, Jonsson KB. GSK-3 inhibition by an orally active small molecule increases bone mass in rats. Bone. March 2012;50(3):619-627.
2020	Matsushita Y, Ono W, Ono N. Growth plate skeletal stem cells and their transition from cartilage to bone. Bone. July 2020;136:115359.
2020	Oichi T, Otsuru S, Usami Y, Enomoto-Iwamoto M, Iwamoto M. Wnt signaling in chondroprogenitors during long bone development and growth. Bone. August 2020;137:115368.
2022	Wang X-j, Yu J-p, An X, Jia Z-w, Zhang J, Su Y-x. Attenuation of cartilage pathogenesis in osteoarthritis by blocking the phosphorylation of tyrosine kinase Fyn to β-catenin, AZD0530. Bone. January 2022;154:116259.
2022	Koide M, Yamashita T, Nakamura K, Yasuda H, Udagawa N, Kobayashi Y. Evidence for the major contribution of remodeling-based bone formation in sclerostin-deficient mice. Bone. July 2022;160:116401.
2018	Aghajanian P, Mohan S. The art of building bone: emerging role of chondrocyte-to-osteoblast transdifferentiation in endochondral ossification. Bone Res. 2018;6:19.
2005	Glass DA II, Bialek P, Ahn JD, Starbuck M, Patel MS, Clevers H, Taketo MM, Long F, McMahon AP, Lang RA, Karsenty G. Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation. Dev Cell. May 2005;8(5):751-764.
2010	Maes C, Kobayashi T, Selig MK, Torrekens S, Roth SI, Mackem S, Carmeliet G, Kronenberg HM. Osteoblast precursors, but not mature osteoblasts, move into developing and fractured bones along with invading blood vessels. Dev Cell. August 17, 2010;19(2):329-344.
2006	Rodda SJ, McMahon AP. Distinct roles for Hedgehog and canonical Wnt signaling in specification, differentiation and maintenance of osteoblast progenitors. Development. August 15, 2006;133(16):3231-3244.
2009	Lin C, Jiang X, Dai Z, Guo X, Weng T, Wang J, Li Y, Feng G, Gao X, He L. Sclerostin mediates bone response to mechanical unloading through antagonizing Wnt/β‐catenin signaling. J Bone Miner Res. October 2009;24(10):1651-1661.
2020	Tan Z, Kong M, Wen S, Tsang KY, Niu B, Hartmann C, Chan D, Hui C, Cheah KSE. IRX3 and IRX5 inhibit adipogenic differentiation of hypertrophic chondrocytes and promote osteogenesis. J Bone Miner Res. December 2020;35(12):2444-2457.
2021	Balani DH, Trinh S, Xu M, Kronenberg HM. Sclerostin antibody administration increases the numbers of Sox9creER+ skeletal precursors and their progeny. J Bone Miner Res. April 2021;36(4):757-767.
2006	Krishnan V, Bryant HU, MacDougald OA. Regulation of bone mass by Wnt signaling. J Clin Invest. May 2006;116(5):1202-1209.
2010	Kramer I, Halleux C, Keller H, Pegurri M, Gooi JH, Weber PB, Feng JQ, Bonewald LF, Kneissel M. Osteocyte Wnt/β-catenin signaling is required for normal bone homeostasis. Mol Cell Biol. June 15, 2010;30(12):3071-3085.
2013	Baron R, Kneissel M. WNT signaling in bone homeostasis and disease: from human mutations to treatments. Nat Med. February 2013;19(2):179-192.
2012	Long F. Building strong bones: molecular regulation of the osteoblast lineage. Nat Rev Mol Cell Biol. January 2012;13(1):27-38.
2014	Zhou X, von der Mark K, Henry S, Norton W, Adams H, de Crombrugghe B. Chondrocytes transdifferentiate into osteoblasts in endochondral bone during development, postnatal growth and fracture healing in mice. PLoS Genet. December 2014;10(12):e1004820.
2010	Eriksen EF. Cellular mechanisms of bone remodeling. Rev Endocr Metab Disord. December 2010;11(4):219-227.
2007	Connelly JT. Regulatory Mechanisms in the Chondrogenesis of Mesenchymal Progenitors: The Roles of Cyclic Tensile Loading and Cell-Matrix Interactions [PhD thesis]. Atlanta, GA: Georgia Institute of Technology; August 2007.
2023	Camacho Sierra P. Multi-Peptide Presentation and Organization in 3D-Printed Scaffolds Drives Osteochondral Tissue Formation [PhD thesis]. Lehigh University; January 2023.
2013	Khayat G. Low Frequency Stimulation of Stem Cells in Dynamic Culture Modulates Differentiation Pathways [PhD thesis]. McGill University; July 2013.
2013	Antolić A. Mitochondrial Contributions to Bone Health, an Investigation Using Two Different Animal Models of Mitochondrial Capacity [PhD thesis]. Hamilton, ON: McMaster University; September 2013.
2009	Miller ES. The Role of E2f4 in Cell Cycle Exit and Bone Development [PhD thesis]. Cambridge, MA: Massachusetts Institute of Technology; June 2009.
2020	Simfia I. Estrogen Deficiency Alters the Mechanobiological Responses of Osteoblasts and Osteocytes [PhD thesis]. National University of Ireland Galway; April 2020.
2017	Morse AR. The Role of Wnt/β-Catenin Antagonists - Sclerostin and DKK1 - in Bone Homeostasis and Mechanotransduction [PhD thesis]. University of Sydney; 2017.
2014	Lin S. DMP1 Regulates Osteocyte Function Via Wnt/β-Catenin Signaling Pathway [PhD thesis]. Texas A&M University; May 2014.
2013	Fowler TW. Activin Regulation of Osteoclast Formation, Motility, Function, and Survival [PhD thesis]. University of Arkansas for Medical Sciences; 2013.
2016	Sebastian A. High-Throughput Analysis of WNT Signaling Pathway in Osteoblasts [PhD thesis]. Merced, CA: Merced, University of California; 2016.
2012	Statman LY. Mechanosensitive Β-Catenin Signaling Modulates Mesenchymal Stem Cell Chondrogenesis [PhD thesis]. San Francisco, University of California; 2012.
2021	Rivera KO. Localized Neurotrophin Delivery Via Microparticles for Enhanced Bone Fracture Repair [PhD thesis]. San Francisco, University of California; 2021.
2018	Wu B. Development of Self-Regulatory Gene Circuits for Cartilage Tissue Engineering [PhD thesis]. University of Michigan; 2018.
2020	Kegelman CD. Combinatorial Roles of Skeletal Cell YAP and TAZ in Bone Growth, Remodeling, and Repair [PhD thesis]. Philadelphia, PA: University of Pennsylvania; 2020.
2019	Xie WX. Insights Into Fracture Repair Using a Murine Model of Osteofibrous Dysplasia [Master's thesis]. Toronto, ON: University of Toronto; 2019.