Wnt signaling in chondroprogenitors during long bone development and growth

Oichi, Takeshi; Otsuru, Satoru; Usami, Yu; Enomoto-Iwamoto, Motomi; Iwamoto, Masahiro

Affiliations

¹Department of Orthopaedics, School of Medicine, University of Maryland, Baltimore, MD, USA

²Department of Oral Pathology, Osaka University Graduate School of Dentistry, Osaka, Japan

Abstract and keywords

Wnt signaling together with other signaling pathways governs cartilage development and the growth plate function during long bone formation and growth. β-catenin-dependent Wnt signaling is a specific lineage determinant of skeletal mesenchymal cells toward chondrogenic or osteogenic direction. Once cartilage forms and the growth plate organize, Wnt signaling continues to regulate proliferation and differentiation of the growth plate chondrocytes. Although chondrocytes in the growth plate have a high capacity to proliferate, new cells must be supplied to the growth plate from chondroprogenitor population. Advances in in vivo cell tracking techniques have demonstrated the importance of Wnt signaling in driving tissue renewal. The Wnt-responsive cells, genetically marked by the Wnt-reporter system, are found as stem cells in various tissues. Similarly, Wnt-responsive cells are found in the periphery of the growth plate and expanded to constitute entire column structure, indicating that Wnt signaling participates in the regulation of chondroprogenitors in the growth plate. This review will discuss advancements in research of progenitors in the growth plate, specifically focusing on Wnt/β-catenin signaling.

Keywords: Chondroprogenitor; Wnt signaling; Growth plate

Links

DOI: 10.1016/j.bone.2020.115368

PubMed: 32380258

WoS: 000547005800007

History

Received: 2020-03-11

Revised: 2020-04-16

Accepted: 2020-04-16

Online: 2020-05-4

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Cited By (1)

Year	Entry
2022	Wang F, Rummukainen P, Pehkonen M, Säämänen A-M, Heino TJ, Kiviranta R. Mesenchymal cell-derived Wnt1 signaling regulates subchondral bone remodeling but has no effects on the development of growth plate or articular cartilage in mice. Bone. October 2022;163:116497.