Bone mechanical properties and changes with osteoporosis

Osterhoff, Georg<sup>1</sup>; Morgan, Elise F.<sup>2</sup>; Shefelbine, Sandra J.<sup>3</sup>; Karim, Lamya<sup>4</sup>; McNamara, Laoise M.<sup>5,6</sup>; Augat, Peter<sup>7</sup>

Affiliations

¹Division of Orthopaedic Trauma, Department of Orthopaedic Surgery, University of British Columbia, Vancouver, British Columbia, Canada

²Department of Mechanical Engineering, Boston University, Boston, MA 02215, USA

³Department of Mechanical and Industrial Engineering, Northeastern University, Boston, MA 02115, USA

⁴Center for Advanced Orthopedic Studies, Beth Israel Deaconess Medical Center and Department of Orthopedic Surgery, Harvard Medical School, Boston, MA 02215, USA

⁵Centre for Biomechanics Research (BMEC), Department of Biomedical Engineering, NUI Galway, Galway, Republic of Ireland

⁶National Centre for Biomedical Engineering Science (NCBES), NUI Galway, Galway, Republic of Ireland

⁷Institute of Biomechanics, Trauma Center Murnau, Murnau, Germany and Paracelsus Medical University Salzburg, Salzburg, Austria

Abstract and keywords

This review will define the role of collagen and within-bone heterogeneity and elaborate the importance of trabecular and cortical architecture with regard to their effect on the mechanical strength of bone. For each of these factors, the changes seen with osteoporosis and ageing will be described and how they can compromise strength and eventually lead to bone fragility.

Keywords: Bone resorption; Bone loss; Bone fragility; Collagen; Biomechanics

Links

DOI: 10.1016/S0020-1383(16)47003-8

PubMed: 27338221

WoS: 000378348500003

History

Revised: 2016-06-1

Online: 2016-06-20

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