The development of the skeleton is a result of genetic regulation as well as epigenetic and environmental factors. In this thesis, it is hypothesized th a t the patterns of endochondral ossification and the construction of initial bone architecture in the developing skeleton are mediated by the mechanical stresses created w ithin the tissues as a result of muscular contraction and movement. A theoretical framework which assumes th at interm ittent shear stresses accelerate ossification and intermittent hydrostatic stresses inhibit ossification is used to describe the mechanical regulation of endochondral ossification. The theory is tested in five separate theoretical simulations of skeletal ontogeny. The predictions from the stress-based algorithm s suggest th at mechanical stresses may be im portant in establishing the site and shape of the secondary ossification centers in diarthrodial joints, the intricate pattern of ossification centers in the developing sternum , and the sequence of endochondral bone formation in long bones. Based on these results, it is likely th at mechanical regulation of skeletal development begins in utero and can significantly affect the final form of the skeleton. The clinical relevance of this predictive methodology to the treatm ent of congenital skeletal displasias is discussed. Also addressed is the possibility th at construction rules may not only be im portant in the ontogeny of the skeleton, but as constraints on the pathw ays of skeletal evolution as well.