Bone cell differentiation and growth factors

Urist, M. R.; DeLange, R. J.; Finerman, G. A.

Affiliations

¹Bone Research Laboratory, University of California Los Angeles (UCLA) Medical School, Los Angeles 90024

Abstract

Bone morphogenetic protein and bone-derived growth factors are biochemical tools for research on induced cell differentiation and local mechanisms controlling cell proliferation. Bone morphogenetic protein irreversibly induces differentiation of perivascular mesenchymal-type cells into osteoprogenitor cells. Bone-derived growth factors are secreted by and for osteoprogenitor cells and stimulate DNA synthesis. Bone generation and regeneration are attributable to the co-efficiency of bone morphogenetic protein and bone-derived growth factors.

Links

DOI: 10.1126/science.6403986

PubMed: 6403986

WoS: A1983QN77100007

Cited By (35)

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