Correlations between mechanical stress history and tissue differentiation in initial fracture healing

Carter, D. R.; Blenman, P. R.; Beaupré, G. S.

Affiliations

¹Department of Mechanical Engineering, Stanford University, Stanford

²Veterans Administration Medical Center, Rehabilitation Research and Development Center, Palo Alto, California, U.S.A.

Abstract and keywords

A general theory for the role of intermittently imposed stresses in the differentiation of mesenchymal tissue is presented and then applied to the process of fracture healing. Two‐dimensional finite element models of a healing osteotomy in a long bone were generated and the stress distributions were calculated throughout the early callus tissue under various loading conditions. These calculations were used in formulating theoretical predictions of tissue differentiation that were consistent with the biochemical and morphological observations of previous investigators. The results suggest that intermittent hydrosatic (dilatational) stresses may play an important role in influencing revascularization and tissue differentiation and determining the morphological patterns of initial fracture healing.

Keywords: Tissue differentiation; Fracture healing; Stress; Vascularity

Links

DOI: 10.1002/jor.1100060517

PubMed: 3404331

WoS: A1988P849300016

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