Pathophysiology of functional adaptation of bone in remodeling and repair in vivo

Goodship, Allen E.; Cunningham, James L.

Year	Entry
1995	Forwood MR, Turner CH. Skeletal adaptations to mechanical usage: results from tibial loading studies in rats. Bone. October 1995;17(4)(suppl):197S-205S.
1996	Lanyon LE. Using functional loading to influence bone mass and architecture: objectives, mechanisms, and relationship with estrogen of the mechanically adaptive process in bone. Bone. January 1996;18(1)(suppl):37S-43S.
1989	Skerry TM, Bitensky L, Chayen J, Lanyon LE. Early strain‐related changes in enzyme activity in osteocytes following bone loading in vivo. J Bone Miner Res. October 1989;4(5):783-788.
2000	Gardner TN, Stoll T, Marks L, Mishra S, Knothe Tate M. The influence of mechanical stimulus on the pattern of tissue differentiation in a long bone fracture: an FEM study. J Biomech. April 2000;33(4):415-425.
1978	Uhthoff HK, Jaworski ZF. Bone loss in response to long-term immobilisation. J Bone Joint Surg. August 1978;60B(3):420-429.
1971	Heřt J, Lišková M, Landa J. Reaction of bone to mechanical stimuli, I: continuous and intermittent loading of tibia in rabbit. Folia Morphol (Praha). August 1971;19(3):290-300.
1972	Chamay A, Tschantz P. Mechanical influences in bone remodeling: experimental research on Wolff's law. J Biomech. March 1972;5(2):173-180.
1979	Goodship AE, Lanyon LE, McFie H. Functional adaptation of bone to increased stress: an experimental study. J Bone Joint Surg. June 1979;61A(4):539-546.
1992	Rubin CT, Bain SD, McLeod KJ. Suppression of the osteogenic response in the aging skeleton. Calcif Tiss Int. April 1992;50(4):306-313.
1994	Chow JW, Chambers TJ. Indomethacin has distinct early and late actions on bone formation induced by mechanical stimulation. Am J Physiol Endocrinol Metab. August 1994;267(2):E287-E292.
1982	Lanyon LE, Goodship AE, Pye CJ, MacFie JH. Mechanically adaptive bone remodelling. J Biomech. 1982;15(3):141-154.
1994	Raab-Cullen DM, Thiede MA, Petersen DN, Kimmel DB, Recker RR. Mechanical loading stimulates rapid changes in periosteal gene expression. Calcif Tiss Int. December 1994;55(6):473-478.
1984	Meade JB, Cowin SC, Klawitter JJ, Van Buskirk WC, Skinner HB. Bone remodeling due to continuously applied loads. Calcif Tiss Int. March 1984;36(suppl 1):S25-S30.
1998	Akhter MP, Cullen DM, Pedersen EA, Kimmel DB, Recker RR. Bone response to in vivo mechanical loading in two breeds of mice. Calcif Tiss Int. November 1998;63(5):442-449.
1995	Rubin CT, Gross TS, McLeod KJ, Bain SD. Morphologie stages in lamellar bone formation stimulated by a potent mechanical stimulus. J Bone Miner Res. March 1995;10(3):488-495.
1994	Bassey EJ, Ramsdale SJ. Increase in femoral bone density in young women following high-impact exercise. Osteoporos Int. March 1994;4(2):72-75.
1998	Mullender M, van Rietbergen B, Rüegsegger P, Huiskes R. Effect of mechanical set point of bone cells on mechanical control of trabecular bone architecture. Bone. February 1998;22(2):125-131.
1988	Carter DR, Blenman PR, Beaupré GS. Correlations between mechanical stress history and tissue differentiation in initial fracture healing. J Orthop Res. September 1988;6(5):736-748.
1999	Claes LE, Heigele CA. Magnitudes of local stress and strain along bony surfaces predict the course and type of fracture healing. J Biomech. March 1999;32(3):255-266.
1997	Judex S, Gross TS, Zernicke RF. Strain gradients correlate with sites of exercise‐induced bone‐forming surfaces in the adult skeleton. J Bone Miner Res. October 1997;12(10):1737-1745.
2000	Fritton SP, McLeod KJ, Rubin CT. Quantifying the strain history of bone: spatial uniformity and self-similarity of low-magnitude strains. J Biomech. March 2000;33(3):317-325.
1979	Perren SM. Physical and biological aspects of fracture healing with special reference to internal fixation. Clin Orthop Relat Res. January–February 1979;138:175-196.
1998	Carter DR, Beaupré GS, Giori NJ, Helms JA. Mechanobiology of skeletal regeneration. Clin Orthop Relat Res. October 1998;355(suppl):S41-S55.
1997	Claes L, Augat P, Suger G, Wilke H-J. Influence of size and stability of the osteotomy gap on the success of fracture healing. J Orthop Res. July 1997;15(4):577-584.
1988	Pead MJ, Suswillo R, Skerry TM, Vedi S, Lanyon LE. Increased ³H-uridine levels in osteocytes following a single short period of dynamic bone loadingin vivo. Calcif Tiss Int. August 1988;43(2):92-96.
1993	Chambers TJ, Evans M, Gardner TN, Turner-Smith A, Chow JWM. Induction of bone formation in rat tail vertebrae by mechanical loading. Bone Miner. February 1993;20(2):167-178.
1991	Cheal EJ, Mansmann KA, Digioia AM III, Hayes WC, Perren SM. Role of interfragmentary strain in fracture healing: ovine model of a healing osteotomy. J Orthop Res. January 1991;9(1):131-142.
1991	Turner CH, Akhter MP, Raab DM, Kimmel DB, Recker RR. A noninvasive, in vivo model for studying strain adaptive bone modeling. Bone. 1991;12(2):73-79.
1988	Skerry TM, Bitensky L, Chayen J, Lanyon LE. Loading-related reorientation of bone proteoglycan in vivo: strain memory in bone tissue? J Orthop Res. July 1988;6(4):547-551.
1989	Pead MJ, Lanyon LE. Indomethacin modulation of load-related stimulation of new bone formation in vivo. Calcif Tiss Int. January 1989;45(1):34-40.
1995	Duncan RL, Turner CH. Mechanotransduction and the functional response of bone to mechanical strain. Calcif Tiss Int. December 1995;57(5):344-358.
1892	Wolff J. Das Gesetz der Transformation der Knochen. Berlin: Hirschwald; 1892.
1984	Lanyon LE, Rubin CT. Static vs dynamic loads as an influence on bone remodelling. J Biomech. 1984;17(12):897-905.
1986	Lanyon LE, Rubin CT, Baust G. Modulation of bone loss during calcium insufficiency by controlled dynamic loading. Calcif Tiss Int. July 1986;38(4):209-216.
1995	Hillam RA, Skerry TM. Inhibition of bone resorption and stimulation of formation by mechanical loading of the modeling rat ulna in vivo. J Bone Miner Res. June 1995;10(5):683-689.
1996	Hillam RA. Response of Bone to Mechanical Load and Alterations in Circulating Hormones [PhD thesis]. Bristol, UK: University of Bristol; October 1996.
1993	Weinans H, Huiskes R, Van Rietbergen B, Sumner DR, Turner TM, Galante JO. Adaptive bone remodeling around bonded noncemented total hip arthroplasty: a comparison between animal experiments and computer simulation. J Orthop Res. July 1993;11(4):500-513.
1986	Jaworski ZFG, Uhthoff HK. Reversibility of nontraumatic disuse osteoporosis during its active phase. Bone. January 1986;7(6):431.
1998	Knothe Tate ML, Knothe U, Niederer P. Experimental elucidation of mechanical load-induced fluid flow and its potential role in bone metabolism and functional adaptation. Am J Med Sci. September 1998;316(3):189-195.
1999	Iwamoto J, Yeh JK, Aloia JF. Differential effect of treadmill exercise on three cancellous bone sites in the young growing rat. Bone. March 1999;24(3):163-169.
1980	Jaworski ZFG, Liskova-Kiar M, Uhthoff HK. Effect of long-term immobilisation on the pattern of bone loss in older dogs. J Bone Joint Surg. February 1980;62B(1):104-110.
2000	Verborgt O, Gibson GJ, Schaffler MB. Loss of osteocyte integrity in association with microdamage and bone remodeling after fatigue in vivo. J Bone Miner Res. January 2000;15(1):60-67.
1990	Skerry TM, Suswillo R, El Haj AJ, Ali NN, Dodds RA, Lanyon LE. Load-induced proteoglycan orientation in bone tissuein vivo and in vitro. Calcif Tiss Int. May 1990;46(5):318-326.
1995	Turner CH, Takano Y, Owan I. Aging changes mechanical loading thresholds for bone formation in rats. J Bone Miner Res. October 1995;10(10):1544-1549.
1984	Rubin CT, Lanyon LE. Regulation of bone formation by applied dynamic loads. J Bone Joint Surg. March 1984;66A(3):397-402.
1998	Bentolila V, Boyce TM, Fyhrie DP, Drumb R, Skerry TM, Schaffler MB. Intracortical remodeling in adult rat long bones after fatigue loading. Bone. September 1998;23(3):275-281.
1983	Biewener AA, Thomason J, Goodship A, Lanyon LE. Bone stress in the horse forelimb during locomotion at different gaits: a comparison of two experimental methods. J Biomech. 1983;16(8):565-576.
1990	Rubin CT, McLeod KJ, Bain SD. Functional strains and cortical bone adaptation: epigenetic assurance of skeletal integrity. J Biomech. 1990;23(suppl 1):43-54.
1998	Turner CH, Pavalko FM. Mechanotransduction and functional response of the skeleton to physical stress: the mechanisms and mechanics of bone adaptation. J Orthop Sci. November 1998;3(6):346-355.
1996	Forwood MR. Inducible cyclo‐oxygenase (COX‐2) mediates the induction of bone formation by mechanical loading in vivo. J Bone Miner Res. November 1996;11(11):1688-1693.
1982	O'Connor JA, Lanyon LE, MacFie H. The influence of strain rate on adaptive bone remodelling. J Biomech. 1982;15(10):767-781.
1998	Qin Y, Rubin CT, McLeod KJ. Nonlinear dependence of loading intensity and cycle number in the maintenance of bone mass and morphology. J Orthop Res. July 1998;16(4):482-489.
1998	Mosley JR, Lanyon LE. Strain rate as a controlling influence on adaptive modeling in response to dynamic loading of the ulna in growing male rats. Bone. October 1998;23(4):313-318.
1985	Rubin CT, Lanyon LE. Regulation of bone mass by mechanical strain magnitude. Calcif Tiss Int. 1985;37(4):411-417.
1985	Goodship AE, Kenwright J. The influence of induced micromovement upon the healing of experimental tibial fractures. J Bone Joint Surg. 1985;67B(4):650-655.
1984	Rubin CT, Lanyon LE. Dynamic strain similarity in vertebrates: an alternative to allometric limb bone scaling. J Theo Biol. March 21, 1984;107(2):321-327.