An investigation into the phenomenon of strain induced remodeling in long bones is described. The research includes the development of a unified theoretical model to describe changes in the geometry and material properties of bone which are dependent on the local strain history. Experimental methods designed to stimulate net remodeling from static loads superimposed on the normal in vivo loads of leporine tibias are described and the quantitative results of these preliminary experimeiits are presented. A computational method for determining the strain distribution and predicting the net remodeling resulting from changes in the geometry and material properties of mathematical models of bone is developed. The method is based on the finite element method and utilizes a quadratic solid element. The model is updated by changing the material properties of an element and the position of the boundary nodes' locations. The remodeling is regulated by remodeling rate equations expressed as functions of the local strain. The use of the computational method to solve simple problems of theoretical interest using linear adaptive elasticity is presented, as is the use of the model with selected experimental bone geometries.