Cyclic AMP and cyclic GMP:​ mediators of the mechanical effects on bone remodeling

Rodan, G. A.; Bourret, L. A.; Harvey, A.; Mensi, T.

Affiliations

¹Department of Oral Biology, University of Connecticut School of Medicine and Dental Medicine, Farmington 06032

Abstract and keywords

Compressive forces of physiological magnitude (60 grams per square centimeter) reduce the adenosine 3',5'-monophosphate and guanosine 3',5'-monophosphate content of the epiphyses of tibiae from 16-day-old chick embryos. An equivalent hydrostatic pressure applied directly to cells isolated from this tissue also affects cyclic nucleotide accumulation. The tissue response is uniform throughout the epiphysis, whereas the cell response varies according to the area of origin.

Keywords:

Links

DOI: 10.1126/science.168639

PubMed: 168639

WoS: A1975AK43600027

History

Received: 1975-01-14

Revised: 1975-02-25

Cited Works (1)

Year	Entry
1892	Wolff J. Das Gesetz der Transformation der Knochen. Berlin: Hirschwald; 1892.

Cited By (38)

Year	Entry
1996	van Rietbergen B. Mechanical Behavior and Adaptation of Trabecular Bone in Relation to Bone Morphology [PhD thesis]. Nijmegen, Netherlands: Catholic University of Nijmegen; 1996.
1991	Chambers TJ. Regulation of osteoclastic bone resorption in vitro. In: Hall BK, ed. Bone. Volume 2: The Osteoclast. Boca Raton, FL: Inc., CRC Press; 1991:141-173.
2001	Brown TD. Devices and techniques for in vitro mechanical stimulation of bone cells. In: Cowin SC, ed. Bone Mechanics Handbook. 2nd ed. Boca Raton, FL: CRC Press; 2001:27-1–27-22.
1994	Goodman SB. The effects of micromotion and particulate materials on tissue differentiation: bone chamber studies in rabbits. Acta Orthop Scand. 1994;65(suppl 258).
2006	Turner CH. Bone strength: current concepts. Annals NY Acad Sci. 2006;1068(1):429-446.
2010	Jacobs CR, Temiyasathit S, Castillo AB. Osteocyte mechanobiology and pericellular mechanics. Annu Rev Biomed Eng. 2010;12:369-400.
1980	Somjen D, Binderman I, Berger E, Harell A. Bone remodelling induced by physical stress is prostaglandin E₂ mediated. Biochim Biophys Acta. January 3, 1980;627(1):91-100.
1991	Jones DB, Nolte H, Scholübbers J-G, Turner E, Veltel D. Biochemical signal transduction of mechanical strain in osteoblast-like cells. Biomaterials. March 1991;12(2):101-110.
2000	Donahue HJ. Gap junctions and biophysical regulation of bone cell differentiation. Bone. May 2000;26(5):417-422.
1984	Yeh C-K, Rodan GA. Tensile forces enhance prostaglandin E synthesis in osteoblastic cells grown on collagen ribbons. Calcif Tiss Int. March 1984;36(1):S67-S71.
1984	Johnson MW. Behavior of fluid in stressed bone and cellular stimulation. Calcif Tiss Int. March 1984;36(suppl 1):S72-S76.
1984	Binderman I, Shimshoni Z, Somjen D. Biochemical pathways involved in the translation of physical stimulus into biological message. Calcif Tiss Int. March 1984;36(1):S82-S85.
1995	Duncan RL, Turner CH. Mechanotransduction and the functional response of bone to mechanical strain. Calcif Tiss Int. December 1995;57(5):344-358.
2014	Schaffler MB, Cheung W-Y, Majeska R, Kennedy O. Osteocytes: master orchestrators of bone. Calcif Tiss Int. January 2014;94(1):5-24.
1985	Lippiello L, Kaye C, Neumata T, Mankin HJ. In vitro metabolic response of articular cartilage segments to low levels of hydrostatic pressure. Connect Tissue Res. 1985;13(2):99-107.
2001	You J, Reilly GC, Zhen X, Yellowley CE, Chen Q, Donahue HJ, Jacobs CR. Osteopontin gene regulation by oscillatory fluid flow via intracellular calcium mobilization and activation of mitogen-activated protein kinase in MC3T3–E1 osteoblasts. J Biol Chem. April 20, 2001;276(16):13365-13371.
1990	Rubin CT, McLeod KJ, Bain SD. Functional strains and cortical bone adaptation: epigenetic assurance of skeletal integrity. J Biomech. 1990;23(suppl 1):43-54.
1991	Carter DR, Wong M, Orr TE. Musculoskeletal ontogeny, phylogeny, and functional adaptation. J Biomech. 1991;24(suppl 1):3-16.
1991	Burger EH, Klein-Nulend J, Veldhuuzen JP. Modulation of osteogenesis in fetal bone rudiments by mechanical stress in vitro. J Biomech. 1991;24(suppl 1):101-109.
1994	Mullender MG, Huiskes R, Weinans H. A physiological approach to the simulation of bone remodeling as a self-organizational control process. J Biomech. November 1994;27(11):1389-1394.
2000	Brown TD. Techniques for mechanical stimulation of cells in vitro: a review. J Biomech. January 2000;33(1):3-14.
2000	You J, Yellowley CE, Donahue HJ, Zhang Y, Chen Q, Jacobs CR. Substrate deformation levels associated with routine physical activity are less stimulatory to bone cells relative to loading-induced oscillatory fluid flow. J Biomech Eng. August 2000;122(4):387-393.
1996	Forwood MR. Inducible cyclo‐oxygenase (COX‐2) mediates the induction of bone formation by mechanical loading in vivo. J Bone Miner Res. November 1996;11(11):1688-1693.
1990	Reich KM, Gay CV, Frangos JA. Fluid shear stress as a mediator of osteoblast cyclic adenosine monophosphate production. J Cell Physiol. April 1990;143(1):100-103.
1986	Schneiderman R, Keret D, Maroudas A. Effects of mechanical and osmotic pressure on the rate of glycosaminoglycan synthesis in the human adult femoral head cartilage: an in vitro study. J Orthop Res. 1986;4(4):393-408.
1983	Hart RT. Quantitative Response of Bone to Mechanical Stress [PhD thesis]. Cleveland, OH: Case Western Reserve University; January 1983.
1990	Simske SJ. Development of Model Osteoporosis in Mice: Alleviation by Electromagnetics and Alternative Treatments [PhD thesis]. University of Colorado; July 1990.
1986	Cheal EJ. Trabecular Bone Remodeling Around Implants [PhD thesis]. Cambridge, MA: Massachusetts Institute of Technology; June 1986.
1983	Rouhana SW. Fluid Flow and Mechanical Damping in Bovine Cortical Bone [PhD thesis]. Troy, NY: Rensselaer Polytechnic Institute; February 1983.
2008	Kwon RY. Mechanical Behavior and Early Molecular Signaling During Mechanotransduction of Fluid Flow in Bone Cells [PhD thesis]. Stanford University; August 2008.
2009	Temiyasathit S. Investigating the Role of Primary Cilia in Mechanotransduction in Bone [PhD thesis]. Stanford University; September 2009.
2020	Pei S. Osteocyte Mechanosensing: Interstitial Fluid Flow, Cellular Response, and Turnover of Pericellular Matrix [PhD thesis]. University of Delaware; 2020.
1996	Adams DJ. Mechanical Factors Initiating Appositional Bone Formation [PhD thesis]. University of Iowa; May 1996.
1995	Guldberg RE. Mechanical Adaptation of Trabecular Bone Formation in Vivo [PhD thesis]. University of Michigan; 1995.
1996	Germiller JA. Influence of Skeletal Muscle on Embryonic Long Bone Development [PhD thesis]. University of Michigan; 1996.
1996	Beck BR. The Relationship of Streaming Potential Magnitude to Strain and Periosteal Modeling [PhD thesis]. Eugene, OR: University of Oregon; December 1996.
1998	Arslanoğlu R. Mathematical Modeling and Experimental Aspects of Cellular Mechanotransduction [PhD thesis]. University of Texas at Austin; December 1998.
2001	Parsamian GP. Damage Mechanics of Human Cortical Bone [PhD thesis]. West Virginia University; 2001.