Theoretical evidence for the generation of high pressure in bone cells

Jendrucko, R. J.; Hymak, W. A.; Newell, Jr, P. H.; Chakrabort, B. K.

Affiliations

¹Bioengineering Program, Texas A & M University, College Station, TX 77843, U.S.A.

Abstract

A simple model of the mechanical behavior of the bone cell-bone matrix composite has been used to compute the hydrostatic pressure which may be developed within osteocytes when bone is placed under stress. Using current estimates of the elastic properties of long bones and single osteons it is shown that predicted pressures are within the range known to affect cellular function.

Links

DOI: 10.1016/0021-9290(76)90127-5

PubMed: 1245494

WoS: A1976BD50800004

History

Received: 1975-02-10

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Cited By (18)

Year	Entry
2001	Lakes R. Viscoelastic properties of cortical bone. In: Cowin SC, ed. Bone Mechanics Handbook. 2nd ed. Boca Raton, FL: CRC Press; 2001:11-1–11-15.
2001	Cowin SC. Bone poroelasticity. In: Cowin SC, ed. Bone Mechanics Handbook. 2nd ed. Boca Raton, FL: CRC Press; 2001:23-1–23-31.
2002	Currey JD. Bones: Structure and Mechanics. Princeton, NJ: Princeton University Press; 2002.
1984	Johnson MW. Behavior of fluid in stressed bone and cellular stimulation. Calcif Tiss Int. March 1984;36(suppl 1):S72-S76.
1982	Johnson MW, Chakkalakal DA, Harper RA, Katz JL, Rouhana SW. Fluid flow in bone in vitro. J Biomech. 1982;15(11):881-885.
1984	Pollack SR, Petrov N, Salzstein R, Brankov G, Blagoeva R. An anatomical model for streaming potentials in osteons. J Biomech. 1984;17(8):627-636.
1990	Kufahl RH, Saha S. A theoretical model for stress-generated fluid flow in the canaliculi-lacunae network in bone tissue. J Biomech. 1990;23(2):171-180.
1999	Cowin SC. Bone poroelasticity. J Biomech. March 1999;32(3):217-238.
1991	Cowin SC, Moss-Salentijn L, Moss ML. Candidates for the mechanosensory system in bone. J Biomech Eng. May 1991;113(2):191-197.
1998	Zhang D, Weinbaum S, Cowin SC. Estimates of the peak pressures in bone pore water. J Biomech Eng. December 1998;120(6):697-703.
1996	Hillam RA. Response of Bone to Mechanical Load and Alterations in Circulating Hormones [PhD thesis]. Bristol, UK: University of Bristol; October 1996.
1983	Hart RT. Quantitative Response of Bone to Mechanical Stress [PhD thesis]. Cleveland, OH: Case Western Reserve University; January 1983.
1983	Rouhana SW. Fluid Flow and Mechanical Damping in Bovine Cortical Bone [PhD thesis]. Troy, NY: Rensselaer Polytechnic Institute; February 1983.
1997	Qin Y-X. Fluid Flow, Matrix Strain and Loading Frequency as Interdependent Control Parameters in Skeletal Adaptation [PhD thesis]. Stony Brook, NY: State University of New York at Stony Brook; May 1997.
1999	Judex S. The Effect of Exercise-Induced Mechanical Stimuli on Cortical Bone [PhD thesis]. Calgary, AB: University of Calgary; 1999.
1996	Adams DJ. Mechanical Factors Initiating Appositional Bone Formation [PhD thesis]. University of Iowa; May 1996.
1996	Beck BR. The Relationship of Streaming Potential Magnitude to Strain and Periosteal Modeling [PhD thesis]. Eugene, OR: University of Oregon; December 1996.
2001	Lee T. Viscoelastic Properties of Biological and High-Damping Composite Materials [PhD thesis]. University of Wisconsin – Madison; 2001.