Despite improvements for both sexes, relative to males, female drivers are at elevated risk of lower extremity injury in front crashes of modern vehicles. Additional progress requires a targeted approach to identify and address factors unique to or more prominent for females. This study focused on front crashes involving drivers restrained by a seat belt and front airbag with low levels of toe pan intrusion. Two field crash datasets were analysed using logistic regression to model the odds of three different AIS≥2 outcomes:​ any lower extremity injury;​ non-ankle/foot injury;​ and right ankle/foot injury. Cases with event data recorder delta-V and precrash braking were used to identify crash- and occupant-related risk factors. Cases with representative Insurance Institute for Highway Safety moderate-overlap crash tests were studied to evaluate the effect of vehicle factors as measured with the Hybrid III 50th percentile male dummy. The risk of a female driver sustaining at least one of the three injury types increased with delta-V, precrash braking, age and body mass index, and decreased with knee airbag deployment. The principal component describing the largest amount of vehicle dummy measurement variation was a meaningful predictor of female driver injury outcome, especially for injuries of the right ankle/foot.