To address persisting sex-based injury risk inequities during motor vehicle crashes, investigations into the underlying physiological components of skeletal fracture resistance could be beneficial. Due to fundamental biological differences between males and females, it cannot be assumed that scaled male volumetric bone mineral density (vBMD) would be accurate for females. Thus, the objective of this study was to quantify intraskeletal variation and the effects of demographic variables on female post-mortem human subjects (PMHS) vBMD and compare to previously reported male data. vBMD was calculated from quantitative computed tomography (QCT) for 70 female PMHS (29-98 years) in the lumbar spine and the left femoral neck, distal radius, and distal tibia. Nuanced patterns of intra-skeletal variation in vBMD were found in females compared to males. Femoral neck vBMD was significantly higher than other sites within their bone type (p<0.01) in both sexes. Effects of age and body size on vBMD were inconsistent across sites in females. Although males had larger radius and tibia vBMD, females had larger femoral neck total and inferior cortex vBMD (p<0.001). These results suggest both anatomical specificity in assessing bone quality as well as fundamental differences in female PMHS vBMD compared to males that could be considered in occupant safety research.
Keywords:
BMD; bone quality; intra-skeletal variation; injury risk; sex differences