Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation

Lacey, D. L; Timms, E.; Tan, H.-L; Kelley, M. J; Dunstan, C. R; Burgess, T.; Elliott, R.; Colombero, A.; Elliott, G.; Scully, S.; Hsu, H.; Sullivan, J.; Hawkins, N.; Davy, E.; Capparelli, C.; Eli, A.; Qian, Y.-X; Kaufman, S.; Sarosi, I.; Shalhoub, V.; Senaldi, G.; Guo, J.; Delaney, J.; Boyle, W. J

Year	Entry
2001	Majeska RJ. Cell biology of bone. In: Cowin SC, ed. Bone Mechanics Handbook. 2nd ed. Boca Raton, FL: CRC Press; 2001:2-1–2-24.
2001	Boskey AL. Bone mineralization. In: Cowin SC, ed. Bone Mechanics Handbook. 2nd ed. Boca Raton, FL: CRC Press; 2001:5-1–5-33.
2011	Feng X, McDonald JM. Disorders of bone remodeling. Annu Rev Pathol. 2011;6:121-145.
2008	Boyce BF, Xing L. Functions of RANKL/RANK/OPG in bone modeling and remodeling. Arch Biochem Biophys. May 15, 2008;473(2):139-146.
2005	Keller H, Kneissel M. SOST is a target gene for PTH in bone. Bone. August 2005;37(2):148-158.
2007	Asagiri M, Takayanagi H. The molecular understanding of osteoclast differentiation. Bone. February 2007;40(2):251-264.
2008	You L, Temiyasathit S, Lee P, Kim CH, Tummala P, Yao W, Kingery W, Malone AM, Kwon RY, Jacobs CR. Osteocytes as mechanosensors in the inhibition of bone resorption due to mechanical loading. Bone. January 2008;42(1):172-179.
2008	Miller PD, Bolognese MA, Lewiecki EM, McClung MR, Ding B, Austin M, Liu Y, San Martin J; AMG 162 Bone Loss Study Group. Effect of denosumab on bone density and turnover in postmenopausal women with low bone mass after long-term continued, discontinued, and restarting of therapy: a randomized blinded phase 2 clinical trial. Bone. August 2008;43(2):222-229.
2010	Lau E, Al-Dujaili S, Guenther A, Liu D, Wang L, You L. Effect of low-magnitude, high-frequency vibration on osteocytes in the regulation of osteoclasts. Bone. June 2010;46(6):1508-1515.
2011	Baron R, Ferrari S, Russell RGG. Denosumab and bisphosphonates: different mechanisms of action and effects. Bone. April 2011;48(4):677-692.
2020	Sugisaki R, Miyamoto Y, Yoshimura K, Sasa K, Kaneko K, Tanaka M, Itose M, Inoue S, Baba K, Shirota T, Chikazu D, Kamijo R. Possible involvement of elastase in enhanced osteoclast differentiation by neutrophils through degradation of osteoprotegerin. Bone. March 2020;132:115216.
2020	Whyte MP, Campeau PM, McAlister WH, Roodman GD, Kurihara N, Nenninger A, Duan S, Gottesman GS, Bijanki VN, Sedighi H, Veis DJ, Mumm S. Juvenile Paget's disease from heterozygous mutation of SP7 encoding osterix (specificity protein 7, transcription factor SP7). Bone. August 2020;137:115364.
2020	Santos MRG, Queiroz-Junior CM, Madeira MFM, Machado FS. Suppressors of cytokine signaling (SOCS) proteins in inflammatory bone disorders. Bone. November 2020;140:115538.
2021	Siddiqui JA, Le Henaff C, Johnson J, He Z, Rifkin DB, Partridge NC. Osteoblastic monocyte chemoattractant protein-1 (MCP-1) mediation of parathyroid hormone's anabolic actions in bone implicates TGF-β signaling. Bone. February 2021;143:115762.
2021	Wang JS, Yoon S-H, Wein MN. Role of histone deacetylases in bone development and skeletal disorders. Bone. February 2021;143:115606.
2021	Goel D, Vohora D. Liver X receptors and skeleton: current state-of-knowledge. Bone. March 2021;144:115807.
2021	Kao S-Y, Katsumi S, Han D, Bizaki-Vallaskangas AJ, Vasilijic S, Landegger LD, Kristiansen AG, McKenna MJ, Stankovic KM. Postnatal expression and possible function of RANK and RANKL in the murine inner ear. Bone. April 2021;145:115837.
2021	Schreuder WH, van der Wal JE, Lange J, van den Berg H. Multiple versus solitary giant cell lesions of the jaw: similar or distinct entities? Bone. August 2021;149:115935.
2022	Takegahara N, Kim H, Choi Y. RANKL biology. Bone. June 2022;159:116353.
2022	Menger MM, Bauer D, Bleimehl M, Scheuer C, Ehnert S, Menger MD, Histing T, Laschke MW. Comparison of two non-union models with damaged periosteum in mice: segmental defect and pin-clip fixation versus transverse fracture and K-wire stabilization. Bone. September 2022;162:116475.
2022	Zhou P, Zheng T, Zhao B. Cytokine-mediated immunomodulation of osteoclastogenesis. Bone. November 2022;164:116540.
2022	Elson A, Anuj A, Barnea-Zohar M, Reuven N. The origins and formation of bone-resorbing osteoclasts. Bone. November 2022;164:116538.
2014	Sims NA, Martin TJ. Coupling the activities of bone formation and resorption: a multitude of signals within the basic multicellular unit. BoneKEy Rep. January 2014;3:481.
2010	Litzenberger JB, Kim J-B, Tummala P, Jacobs CR. Β₁ integrins mediate mechanosensitive signaling pathways in osteocytes. Calcif Tiss Int. April 2010;86(4):325-332.
2020	Xin Y, Liu Y, Liu D, Li J, Zhang C, Wang Y, Zheng S. New function of RUNX2 in regulating osteoclast differentiation via the AKT/NFATc1/CTSK axis. Calcif Tiss Int. May 2020;106(5):553-566.
2021	Carrillo-López N, Martínez-Arias L, Fernández-Villabrille S, Ruiz-Torres MP, Dusso A, Cannata-Andía JB, Naves-Díaz M, Panizo S; European Renal Osteodystrophy (EUROD) Workgroup. Role of the RANK/RANKL/OPG and Wnt/β-catenin systems in CKD bone and cardiovascular disorders. Calcif Tiss Int. April 2021;108(4):439-451.
2000	Ducy P, Amling M, Takeda S, Priemel M, Schilling AF, Beil FT, Shen J, Vinson C, Rueger JM, Karsenty G. Leptin inhibits bone formation through a hypothalamic relay: a central control of bone mass. Cell. January 21, 2000;100(2):197-207.
2002	Karsenty G, Wagner EF. Reaching a genetic and molecular understanding of skeletal development. Dev Cell. April 2002;2(4):389-406.
2002	Takayanagi H, Kim S, Koga T, Nishina H, Isshiki M, Yoshida H, Saiura A, Isobe M, Yokochi T, Inoue J-i, Wagner EF, Mak TW, Kodama T, Taniguchi T. Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts. Dev Cell. December 1, 2002;3(6):889-901.
2005	Glass DA II, Bialek P, Ahn JD, Starbuck M, Patel MS, Clevers H, Taketo MM, Long F, McMahon AP, Lang RA, Karsenty G. Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation. Dev Cell. May 2005;8(5):751-764.
2006	Franz-Odendaal TA, Hall BK, Witten PE. Buried alive: how osteoblasts become osteocytes. Dev Dyn. January 2006;235(1):176-190.
1999	Suda T, Takahashi N, Udagawa N, Jimi E, Gillespie MT, Martin TJ. Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families. Endocr Rev. June 1999;20(3):345-357.
2000	Manolagas SC. Birth and death of bone cells: basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis. Endocr Rev. April 2000;21(2):115-137.
2022	Loundagin LL, Cooper DML. Towards novel measurements of remodelling activity in cortical bone: implications for osteoporosis and related pharmaceutical treatments. Eur Cell Mater. 2022;43:202-227.
2010	Raggatt LJ, Partridge NC. Cellular and molecular mechanisms of bone remodeling. J Biol Chem. August 13, 2010;285(33):25103-25108.
2001	Kon T, Cho T-J, Aizawa T, Yamazaki M, Nooh N, Graves D, Gerstenfeld LC, Einhorn TA. Expression of osteoprotegerin, receptor activator of NF-κB ligand (osteoprotegerin ligand) and related proinflammatory cytokines during fracture healing. J Bone Miner Res. June 2001;16(6):1004-1014.
2007	Lewiecki EM, Miller PD, McClung MR, Cohen SB, Bolognese MA, Liu Y, Wang A, Siddhanti S, Fitzpatrick LA; AMG 162 Bone Loss Study Group. Two-year treatment with denosumab (AMG 162) in a randomized phase 2 study of postmenopausal women with low BMD. J Bone Miner Res. December 2007;22(12):1832-1841.
2008	Kogianni G, Mann V, Noble BS. Apoptotic bodies convey activity capable of initiating osteoclastogenesis and localized bone destruction. J Bone Miner Res. June 2008;23(6):915-927.
2009	Brown JP, Prince RL, Deal C, Recker RR, Kiel DP, Gregorio LHd, Hadji P, Hofbauer LC, Álvaro-Gracia JM, Wang H, Austin M, Wagman RB, Newmark R, Libanati C, San Martin J, Bone HG. Comparison of the effect of denosumab and alendronate on BMD and biochemical markers of bone turnover in postmenopausal women with low bone mass: a randomized, blinded, phase 3 trial. J Bone Miner Res. January 2009;24(1):153-161.
2010	Kendler DL, Roux C, Benhamou CL, Brown JP, Lillestol M, Siddhanti S, Man H-S, San Martin J, Bone HG. Effects of denosumab on bone mineral density and bone turnover in postmenopausal women transitioning from alendronate therapy. J Bone Miner Res. January 2010;25(1):72-81.
2010	Reid IR, Miller PD, Brown JP, Kendler DL, Fahrleitner-Pammer A, Valter I, Maasalu K, Bolognese MA, Woodson G, Bone H, Ding B, Wagman RB, San Martin J, Ominsky MS, Dempster DW; Denosumab Phase 3 Bone Histology Study Group. Effects of denosumab on bone histomorphometry: the FREEDOM and STAND studies. J Bone Miner Res. October 2010;25(10):2256-2265.
2020	Kittaka M, Yoshimoto T, Schlosser C, Rottapel R, Kajiya M, Kurihara H, Reichenberger EJ, Ueki Y. Alveolar bone protection by targeting the SH3BP2‐SYK axis in osteoclasts. J Bone Miner Res. February 2020;35(2):382-395.
2020	Loftus A, Cappariello A, George C, Ucci A, Shefferd K, Green A, Paone R, Ponzetti M, Delle Monache S, Muraca M, Teti A, Rucci N. Extracellular vesicles from osteotropic breast cancer cells affect bone resident cells. J Bone Miner Res. February 2020;35(2):396-412.
2020	Zhou Y, Yang Y, Jing Y, Yuan T, Sun L, Tao B, Liu J, Zhao H. BMP9 reduces bone loss in ovariectomized mice by dual regulation of bone remodeling. J Bone Miner Res. May 2020;35(5):978-993.
2020	Chotiyarnwong P, McCloskey E, Eastell R, McClung MR, Gielen E, Gostage J, McDermott M, Chines A, Huang S, Cummings SR. A pooled analysis of fall incidence from placebo‐controlled trials of denosumab. J Bone Miner Res. June 2020;35(6):1014-1021.
2020	Qian Z, Zhang Y, Kang X, Li H, Zhang Y, Jin X, Gao X, Xu M, Ma Z, Zhao L, Zhang Z, Sun H, Wu S. Postnatal conditional deletion of Bmal1 in osteoblasts enhances trabecular bone formation via increased BMP2 signals. J Bone Miner Res. August 2020;35(8):1481-1493.
2003	Eghbali-Fatourechi G, Khosla S, Sanyal A, Boyle WJ, Lacey DL, Riggs BL. Role of RANK ligand in mediating increased bone resorption in early postmenopausal women. J Clin Invest. April 2003;111(8):1221-1230.
2010	Stopeck AT, Lipton A, Body J-J, Steger GG, Tonkin K, Lichinitser RH, de Boer M, Fujiwara Y, Yardley DA, Viniegra M, Fan M, Jiang Q, Dansey R, Jun S, Braun A. Denosumab compared with zoledronic acid for the treatment of bone metastases in patients with advanced breast cancer: a randomized, double-blind study. J Clin Oncol. December 10, 2010;28(35):5132-5139.
2002	Nakamura H, Tsuji T, Hirata A, Yamamoto T. Localization of osteoprotegerin (OPG) on bone surfaces and cement lines in rat tibia. J Histochem Cytochem. 2002;50(7):945-953.
2022	Becerikli M, Reinkemeier F, Dadras M, Wallner C, Wagner JM, Drysch M, Sogorski A, von Glinski M, Lehnhardt M, Hahn SA, Behr B. TGF-beta pathway inhibition as the therapeutic acceleration of diabetic bone regeneration. J Orthop Res. August 2022;40(8):1810-1826.
2013	Tsai JN, Uihlein AV, Lee H, Kumbhani R, Siwila-Sackman E, McKay EA, Burnett-Bowie S-AM, Neer RM, Leder BZ. Teriparatide and denosumab, alone or combined, in women with postmenopausal osteoporosis: the DATA study randomised trial. Lancet. July 6, 2013;382(9886):50-56.
2017	Khosla S, Hofbauer LC. Osteoporosis treatment: recent developments and ongoing challenges. Lancet Diabetes Endocrinol. November 2017;5(11):898-907.
2011	Xiong J, Onal M, Jilka RL, Weinstein RS, Manolagas SC, O'Brien CA. Matrix-embedded cells control osteoclast formation. Nat Med. November 2011;17(10):1235-1242.
2013	Sobacchi C, Schulz A, Coxon FP, Villa A, Helfrich MH. Osteopetrosis: genetics, treatment and new insights into osteoclast function. Nat Rev Endocrinol. September 2013;9(9):522-536.
1999	Kong Y-Y, Yoshida H, Sarosi I, Tan H-L, Timms E, Capparelli C, Morony S, Oliveira-dos-Santos AJ, Van G, Itie A, Khoo W, Wakeham A, Dunstan CR, Lacey DL, Mak TW, Boyle WJ, Penninger JM. OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis. Nature. January 28, 1999;397(6717):315-323.
1999	Kong Y-Y, Feige U, Sarosi I, Bolon B, Tafuri A, Morony S, Capparelli C, Li J, Elliott R, McCabe S, Wong T, Campagnuolo G, Moran E, Bogoch ER, Van G, Nguyen LT, Ohashi PS, Lacey DL, Fish E, Boyle WJ, Penninger JM. Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand. Nature. November 18, 1999;402(6759):304-309.
2003	Boyle WJ, Simonet WS, Lacey DL. Osteoclast differentiation and activation. Nature. May 15, 2003;423(6937):337-342.
2004	Roodman GD. Mechanisms of bone metastasis. NEJM. April 15, 2004;350(16):1655-1664.
2020	Miller PD, Pannacciulli N, Malouf-Sierra J, Singer A, Czerwiński E, Bone HG, Wang C, Huang S, Chines A, Lems W, Brown JP. Efficacy and safety of denosumab vs. bisphosphonates in postmenopausal women previously treated with oral bisphosphonates. Osteoporos Int. January 2020;31(1):181-191.
2021	McAlpine M. Tea Types and Their Effects on in Vitro Mineralization and in Vivo Bone Structure and Density [PhD thesis]. Brock University; 2021.
2006	Poole KES. The Effects of Stroke on the Skeleton [PhD thesis]. Cambridge, UK: University of Cambridge; 2006.
2015	Scully N. Differentiation of Osteoblasts to Osteocytes in 3D Type I Collagen Gels: A Novel Tool to Study Osteocyte Responses to Mechanical Loading [PhD thesis]. Cardiff, UK: Cardiff University; April 2015.
2007	Yuan Y. The Differential Effects of Two Critical Osteoclastogenesis Stimulating Factors on Bone Biomechanics [PhD thesis]. Clemson, SC: Clemson University; May 2007.
2008	Willey JS. Radiation-Induced Osteoporosis: Bone Quantity, Architecture, and Increased Resorption Following Exposure to Ionizing Radiation [PhD thesis]. Clemson, SC: Clemson University; May 2008.
2017	Bowman LC. Whole Body Irradiation and Degradation of Structural and Functional Properties of Mouse Bone: X-Rays, Protons, and Heavy Ions [PhD thesis]. Clemson, SC: Clemson University; December 2017.
1998	Bateman TA. Cytokine Therapies for Short-Term Disuse Osteopenia Models in Murines [PhD thesis]. University of Colorado; 1998.
2014	Lee HG. Innate Immune-Like Function of Osteogenic Cells and Their Effects on Inflammatory Osteolysis [PhD thesis]. Columbia University; 2014.
2017	Kelly NH. Transcriptomic Analysis of Cortical Versus Cancellous Bone in Response to Mechanical Loading and Estrogen Signaling [PhD thesis]. Ithaca, NY: Cornell University; January 2017.
2020	Axelsson KF. Aspects of Fracture Prevention: The Role of Fracture Liaison Services and Alendronate [PhD thesis]. University of Gothenburg; 2020.
2019	Ilas DC. The Role of Mesenchymal Stem Cells and Osteocytes in Subchondral Bone Changes in Hip Osteoarthritis [PhD thesis]. University of Leeds; May 2019.
2011	Linares GR. Novel Molecules That Regulate Bone Formation and Bone Resorption [PhD thesis]. Loma Linda University; June 2011.
2014	Alshbool FZ. The Role of Claudins in Bone Metabolism [PhD thesis]. Loma Linda University; December 2014.
2008	Herman BC. Osteocytes and Activation of Bone Remodeling [PhD thesis]. Mount Sinai School of Medicine; 2008.
2019	Piet J. Restoring Mechano-Adaptation in Aged Murine Bone [PhD thesis]. Northeastern University; March 2019.
2017	Pearson HB. BMP-2 Indirectly Induces Angiogenesis During Large Bone Defect Regeneration [Master's thesis]. University of Notre Dame; July 2017.
2020	Simfia I. Estrogen Deficiency Alters the Mechanobiological Responses of Osteoblasts and Osteocytes [PhD thesis]. National University of Ireland Galway; April 2020.
2005	Pitner ND. Evaluation of the Role of Low-Density Lipoprotein Receptor-Related Protein 5 (lrp5) in Regulating Bone Mass [PhD thesis]. Purdue University; December 2005.
2017	Owen R. Tissue Engineering an in Vitro Model of Osteoporosis [PhD thesis]. Sheffield, UK: University of Sheffield; October 2017.
2017	Richter RD. Development of a Bioreactor to Study Bone Cell Responses to Ultrasound [Master's thesis]. St. Louis, MO: Saint Louis University; 2017.
2009	Litzenberger JB. The Role of Integrin Signaling in Bone Mechanotransduction [PhD thesis]. Stanford University; 2009.
2012	Uzer G. Role of Fluid Shear Modulation on Bone Cell Metabolism During High-Frequency Oscillatory Vibrations [PhD thesis]. Stony Brook, NY: Stony Brook University; December 2012.
2017	Morse AR. The Role of Wnt/β-Catenin Antagonists - Sclerostin and DKK1 - in Bone Homeostasis and Mechanotransduction [PhD thesis]. University of Sydney; 2017.
2008	Mulvihill BMC. Computational Investigation Into the Mechanoregulation of Osteoporosis [PhD thesis]. Trinity College Dublin; December 2008.
2013	Newa M. Antibody Mediated “Universal” Osteoclast Targeting Platform [PhD thesis]. Edmonton, AB: University of Alberta; 2013.
2013	Fowler TW. Activin Regulation of Osteoclast Formation, Motility, Function, and Survival [PhD thesis]. University of Arkansas for Medical Sciences; 2013.
2019	Emami AJ. Systemic Bone Loss After Femoral Fracture in Mice: Potential Mechanisms and Age-Related Effects [PhD thesis]. Davis, University of California; 2019.
2019	Küsters NV. Auswirkungen des Alters und der Knochenmikroarchitektur auf die trabekuläre Knochenmineralisationsdichteverteilung: Eine rasterelektronenmikroskopische Studie an 152 humanen Beckenkammbiopsien [PhD thesis]. Hamburg, Germany: Universität Hamburg; 2019.
2016	Vrahna C. Investigating the Effects of Downstream Parathyroid Hormone (PTH) Targets on Bone Strength and Quality [PhD thesis]. Melbourne, Australia: The University of Melbourne; December 2016.
2023	Kotsanti M. Evaluation of Mandibular Cortical Bone in a Healthy Paediatric Population [Master's thesis]. National and Kapodistrian University of Athens; 2023.
2010	Magalhaes JKRS. The Role of Rac1 and Rac2 in Determining Bone Quality in Aged and Osteoporotic Female Mouse Models [Master's thesis]. University of Toronto; 2010.
2015	Ng AH-M. A Mouse Model of Adynamic Bone Disease (ABD) and Its Consequences on Bone Quality With Age [PhD thesis]. University of Toronto; 2015.
2007	McDonald MM. The Role of the Osteoclast During Endochondral Ossification in a Rat Fracture Model [PhD thesis]. University of Technology Sydney (UTS); May 2007.
2014	Gandhi C. Effects of Matrix Advanced Glycation End Products on Human Osteoclast Resorption of Human Cortical Bone [Master's thesis]. San Antionio, TX: University of Texas at San Antonio; May 2014.
2019	Putnam NE. Innate Immunity and Bone Remodeling During Staphylococcus Aureus Osteomyelitis [PhD thesis]. Nashville, TN: Vanderbilt University; June 30, 2019.
2013	Ausk BJ. Identifying the Origins of Bone Loss Induced by Transient Muscle Paralysis Using Novel MicroCT Image Registration Techniques [PhD thesis]. University of Washington; 2013.