Cellular and molecular mechanisms of bone remodeling

Raggatt, Liza J.<sup>1,2</sup>; Partridge, Nicola C.<sup>3</sup>

Year	Entry
2013	Andersen TL, Abdelgawad ME, Kristensen HB, Hauge EM, Rolighed L, Bollerslev J, Kjærsgaard-Andersen P, Delaisse J-M. Understanding coupling between bone resorption and formation: are reversal cells the missing link? Am J Pathol. July 2013;183(1):235-246.
2020	Kim H-m, He L, Lee S, Park C, Kim DH, Han H-J, Han J, Hwang J, Cha-Molstad H, Lee KH, Ko S-K, Jang J-H, Ryoo I-J, Blenis J, Lee HG, Ahn JS, Kwon YT, Soung N-K, Kim BY. Inhibition of osteoclasts differentiation by CDC2-induced NFATc1 phosphorylation. Bone. February 2020;131:115153.
2020	Ascenzi M-G. Theoretical mathematics, polarized light microscopy and computational models in healthy and pathological bone. Bone. May 2020;134:115295.
2020	Blixt N, Norton A, Zhang A, Aparicio C, Prasad H, Gopalakrishnan R, Jensen ED, Mansky KC. Loss of myocyte enhancer factor 2 expression in osteoclasts leads to opposing skeletal phenotypes. Bone. September 2020;138:115466.
2020	van der Burgh AC, Oliai Araghi S, Zillikens MC, Koromani F, Rivadeneira F, van der Velde N, Hoorn EJ, Uitterlinden AG, Ikram MA, Stricker BH. The impact of thiazide diuretics on bone mineral density and the trabecular bone score: the Rotterdam Study. Bone. September 2020;138:115475.
2022	Tsuda E, Fukuda C, Okada A, Karibe T, Hiruma Y, Takagi N, Isumi Y, Yamamoto T, Hasegawa T, Uehara S, Koide M, Udagawa N, Amizuka N, Kumakura S. Characterization, pharmacokinetics, and pharmacodynamics of anti-Siglec-15 antibody and its potency for treating osteoporosis and as follow-up treatment after parathyroid hormone use. Bone. February 2022;155:116241.
2022	Chen J-R, Lazarenko OP, Blackburn ML. GPR109A gene deletion ameliorates gonadectomy-induced bone loss in mice. Bone. August 2022;161:116422.
2023	Yang KG, Goff E, Cheng K-l, Kuhn GA, Wang Y, Cheng JC-y, Qiu Y, Müller R, Lee WY-w. Abnormal morphological features of osteocyte lacunae in adolescent idiopathic scoliosis: a large-scale assessment by ultra-high-resolution micro-computed tomography. Bone. January 2023;166:116594.
2024	Monteiro AC, de Andrade Garcia D, Du Rocher B, Fontão APGA, Nogueira LP, Fidalgo G, Colaço MV, Bonomo A. Cooperation between T and B cells reinforce the establishment of bone metastases in a mouse model of breast cancer. Bone. January 2024;178:116932.
2020	Lademann F, Weidner H, Tsourdi E, Kumar R, Rijntjes E, Köhrle J, Hofbauer LC, Rauner M. Disruption of BMP signaling prevents hyperthyroidism‐induced bone loss in male mice. J Bone Miner Res. October 2020;35(10):2058-2069.
2022	Dolan CP, Imholt F, Yang T-J, Bokhari R, Gregory J, Yan M, Qureshi O, Zimmel K, Sherman KM, Falck A, Yu L, Leininger E, Brunauer R, Suva LJ, Gaddy D, Dawson LA, Muneoka K. Mouse digit tip regeneration is mechanical load dependent. J Bone Miner Res. February 2022;37(2):312-322.
2023	Gong X, Sun S, Yang Y, Huang X, Gao X, Jin A, Xu H, Wang X, Liu Y, Liu J, Dai Q, Jiang L. Osteoblastic STAT3 is crucial for orthodontic force driving alveolar bone remodeling and tooth movement. J Bone Miner Res. January 2023;38(1):214-227.
2023	Wu P-h, Joseph G, Saeed I, Pirmoazen AM, Kenny K, Kim TY, Schafer AL, Schwartz AV, Li X, Link TM, Kazakia GJ. Bone marrow adiposity alterations in Type 2 diabetes are sex-specific and associated with serum lipid levels. J Bone Miner Res. December 2023;38(12):1877-1884.
2021	Palumbo C, Ferretti M. The osteocyte: from "prisoner" to "orchestrator". J Funct Morphol Kinesiol. 2021;6(1):28.
2020	Hart NH, Newton RU, Tan2 J, Rantalainen T, Chivers P, Siafarikas A, Nimphius S. Biological basis of bone strength: anatomy, physiology and measurement. J Musculoskel Neuron Interact. September 2020;20(3):347-371.
2020	Kim G, Kim D, Lee K, Kim D, Chung K, Choi JW, An JH. Effect of nano-montmorillonite on osteoblast differentiation, mineral density, and osteoclast differentiation in bone formation. Nanomaterials. 2020;10(2):230.
2019	Cashen JR. A Comparison of Osteoblast and Osteocyte Expression in Human Bone and Cultured Mesenchymal Stem Cells [Master's thesis]. Boston, MA: Boston University; 2019.
2019	Ó Breasail M. The Quantification of Pregnancy-Induced Bone Mineral Mobilisation in the Maternal Appendicular Skeleton With Novel Peripheral Quantitative Computed Tomography (pQCT) Techniques [PhD thesis]. Cambridge, UK: University of Cambridge; 2019.
2015	Scully N. Differentiation of Osteoblasts to Osteocytes in 3D Type I Collagen Gels: A Novel Tool to Study Osteocyte Responses to Mechanical Loading [PhD thesis]. Cardiff, UK: Cardiff University; April 2015.
2013	Cureton AC. Bone Morphology and Mechanical Properties in Murine Models of Chronic Kidney Disease [Master's thesis]. University of Colorado; 2013.
2021	Duffy MP. The Osteocyte Primary Cilium is a Mechanoresponsive Organelle That Regulates Cytoskeletal Adaptation and Coordinates Mechanotransduction With Adenylyl Cyclases [PhD thesis]. Columbia University; 2021.
2020	Yu T. Chondroitin Sulfate Conjugated Nanofiber Shish Kebabs as Biomimetic Bone Templates [PhD thesis]. Drexel University; January 2020.
2015	Nogueira RC. Exercising Opportunities to Prevent Chronic Disease: The CAPO Kids Trial [PhD thesis]. Brisbane, Australia: Griffith University; 2015.
2019	Bakr M. Parathyroid Hormone Effect on Facilitating Stress Fracture Repair [PhD thesis]. Brisbane, Australia: Griffith University; July 2019.
2020	Song H. The Effect of Mechanical Loading on Bone During Growth [PhD thesis]. University of Illinois at Urbana-Champaign; 2020.
2021	Yan C. Tibial Bone Properties and Mechanics Under Atypical Loading Conditions [PhD thesis]. University of Illinois at Urbana-Champaign; 2021.
2011	Moodie J. Destabilisation of the Medial Meniscus: Imaging and Mechanics of a Murine Surgical Osteoarthritis Model [PhD thesis]. Imperial College London; August 2011.
2019	Du J. Mechanical Adaptation of Human Trabecular Bone: Experimental and Computational Study [PhD thesis]. Loughborough University; 2019.
2011	Linares GR. Novel Molecules That Regulate Bone Formation and Bone Resorption [PhD thesis]. Loma Linda University; June 2011.
2011	Rose D. The Use of Geographical Information Systems Software for the Spatial Analysis of Bone Microstructure [Master's thesis]. The Ohio State University; 2011.
2023	Hua Y. Body Composition and Bone Characteristics Data in NCAA D1 League Football Team by DXA and HRpQCT [Master's thesis]. University of Pittsburgh; 2023.
2020	Doolittle ML. Dissecting the Genetic Influences on Osteoporosis Reveals Zbtb40* as a Novel Regulator of Osteoblast Function* [PhD thesis]. University of Rochester; 2020.
2017	Owen R. Tissue Engineering an in Vitro Model of Osteoporosis [PhD thesis]. Sheffield, UK: University of Sheffield; October 2017.
2021	Frank M. Mechanical Characterization of Individual Trabeculae [PhD thesis]. Vienna University of Technology; February 2021.
2019	Lee JJH. Activation of the Calcium Sensing Receptor Attenuates TRPV6-Dependent Intestinal Calcium Absorption [Master's thesis]. Edmonton, AB: University of Alberta; 2019.
2011	Kristensen E. The Role of Growth Hormone in the Development of Bone Microarchitecture, Craniofacial Shape and Bone Strength [PhD thesis]. Calgary, AB: University of Calgary; February 2011.
2021	Besler BAA. Bone as an Orientable, Smooth Surface: Distance Transforms, Morphometry, and Adaptation [PhD thesis]. Calgary, AB: University of Calgary; August 2021.
2022	Wyatt P. Bone Quality of Elite Winter Endurance Athletes [Master's thesis]. Calgary, AB: University of Calgary; April 2022.
2021	Cunningham HC. Bone Adaptation to Disuse in Aging Rodents: Age-Related Differences in Response to Mechanical Unloading and Subsequent Reloading [PhD thesis]. Davis, University of California; 2021.
2020	Link JM. Toward Enhancing the Durability and Integration of Engineered Articular Cartilage [PhD thesis]. Irvine, CA: Irvine, University of California; 2020.
2020	Salinas EY. Using Mechanical Stimulation to Improve Tissue-Engineered Articular Cartilage for Implantation in the Knee Joint [PhD thesis]. Irvine, CA: Irvine, University of California; 2020.
2019	Mendez MEA. The Role of Inflammation and Antibiotics in the Development of Post-Traumatic Osteoarthritis in Mice [PhD thesis]. Merced, University of California; 2019.
2016	Yuen JSK Jr. A New, Potential Mechanism for Osteoblast Initiated Lamellar Bone Formation During Bone Remodelling [Master's thesis]. San Siego, CA: University of California San Diego; 2016.
2020	Locke RC. Preclinical Translation of Therapeutic Interventions for Tendon Injury [PhD thesis]. University of Delaware; 2020.
2023	Austermann K. Effects of Nutritive Antioxidants on Bone During Immobility [PhD thesis]. Rheinische Friedrich-Wilhelms-Universität Bonn; 2023.
2013	Blaber EA. Stem Cell-Based Tissue Regeneration in Space [PhD thesis]. University of New South Wales; November 2013.
2020	Hiebert B. The Development of a Cortical Bone Turnover Model: Parathyroid Hormone Effects in the Rabbit [Master's thesis]. University of Saskatchewan; July 2020.
2022	Sales EdS. The Spatio-Temporal Behavior of Basic Multicellular Units in a PTH-Induced Cortical Bone Remodeling Rabbit Model [Master's thesis]. University of Saskatchewan; August 2022.
2021	Lo CH. Bone Microenvironmental Control of Skeletal Malignancy [PhD thesis]. University of South Florida; 2021.
2018	Burke MV. Quantification of Changes in Vertebral Bone Quality in the Presence of Metastases [PhD thesis]. University of Toronto; 2018.
2019	Mei X. Microfluidic Platform for Investigating Osteocyte Mechanoregulation of Breast Cancer Bone Metastasis [Master's thesis]. University of Toronto; 2019.
2021	Feng GL. The Role of Arrestin-3 in Bone Catabolic Response to Hyperparathyroidism [Master's thesis]. University of Toronto; 2021.
2019	Nguyen J. The Effect of Cortical Remodeling on Bone Stiffness in White-Tailed Deer Proximal Humerus [Master's thesis]. Rock Hill, SC: Winthrop University; May 2019.

Year	Entry
2008	Robling AG, Niziolek PJ, Baldridge LA, Condon KW, Allen MR, Alam I, Mantila SM, Gluhak-Heinrich J, Bellido TM, Harris SE, Turner CH. Mechanical stimulation of bone in vivo reduces osteocyte expression of Sost/sclerostin. J Biol Chem. February 29, 2008;283(9):5866-5875.
2009	Andersen TL, Sondergaard TE, Skorzynska KE, Dagnaes-Hansen F, Plesner TL, Hauge EM, Plesner T, Delaisse J-M. A physical mechanism for coupling bone resorption and formation in adult human bone. Am J Pathol. January 2009;174(1):239-247.
2005	Li X, Zhang Y, Kang H, Liu W, Liu P, Zhang J, Harris SE, Wu D. Sclerostin binds to LRP5/6 and antagonizes canonical Wnt signaling. J Biol Chem. May 20, 2005;280(20):19883-19887.
2002	Everts V, Delaissé JM, Korper W, Jansen DC, Tigchelaar-Gutter W, Saftig P, Beertsen W. The bone lining cell: its role in cleaning Howship's lacunae and initiating bone formation. J Bone Miner Res. January 2002;17(1):77-90.
1997	Otto F, Thornell AP, Crompton T, Denzel A, Gilmour KC, Rosewell IR, Stamp GW, Beddington RS, Mundlos S, Olsen BR, Selby PB, Owen MJ. Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development. Cell. May 30, 1997;89(5):765-771.
2004	van Bezooijen RL, Roelen BAJ, Visser A, van der Wee-Pals L, de Wilt E, Karperien M, Hamersma H, Papapoulos SE, ten Dijke P, Löwik CWGM. Sclerostin is an osteocyte-expressed negative regulator of bone formation, but not a classical BMP antagonist. J Exp Med. March 15, 2004;199(6):805-814.
2001	Kamioka H, Honjo T, Takano-Yamamoto T. A three-dimensional distribution of osteocyte processes revealed by the combination of confocal laser scanning microscopy and differential interference contrast microscopy. Bone. February 2001;28(2):145-149.
1998	Lacey DL, Timms E, Tan H-L, Kelley MJ, Dunstan CR, Burgess T, Elliott R, Colombero A, Elliott G, Scully S, Hsu H, Sullivan J, Hawkins N, Davy E, Capparelli C, Eli A, Qian Y-X, Kaufman S, Sarosi I, Shalhoub V, Senaldi G, Guo J, Delaney J, Boyle WJ. Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation. Cell. April 17, 1998;93(2):165-176.
2000	Teitelbaum SL. Bone resorption by osteoclasts. Science. September 1, 2000;289(5484):1504-1508.
2002	Takayanagi H, Kim S, Koga T, Nishina H, Isshiki M, Yoshida H, Saiura A, Isobe M, Yokochi T, Inoue J-i, Wagner EF, Mak TW, Kodama T, Taniguchi T. Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts. Dev Cell. December 1, 2002;3(6):889-901.
2001	Hauge EM, Qvesel D, Eriksen EF, Mosekilde L, Melsen F. Cancellous bone remodeling occurs in specialized compartments lined by cells expressing osteoblastic markers. J Bone Miner Res. September 2001;16(9):1575-1582.
1999	Kong Y-Y, Yoshida H, Sarosi I, Tan H-L, Timms E, Capparelli C, Morony S, Oliveira-dos-Santos AJ, Van G, Itie A, Khoo W, Wakeham A, Dunstan CR, Lacey DL, Mak TW, Boyle WJ, Penninger JM. OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis. Nature. January 28, 1999;397(6717):315-323.
1997	Komori T, Yagi H, Nomura S, Yamaguchi A, Sasaki K, Deguchi K, Shimizu Y, Bronson RT, Gao Y-H, Inada M, Sato M, Okamoto R, Kitamura Y, Yoshiki S, Kishimoto T. Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts. Cell. May 30, 1997;89(5):755-764.
2006	Aguirre JI, Plotkin LI, Stewart SA, Weinstein RS, Parfitt AM, Manolagas SC, Bellido T. Osteocyte apoptosis is induced by weightlessness in mice and precedes osteoclast recruitment and bone loss. J Bone Miner Res. April 2006;21(4):605-615.
2002	Verborgt O, Tatton NA, Majeska RJ, Schaffler MB. Spatial distribution of Bax and Bcl-2 in osteocytes after bone fatigue: complementary roles in bone remodeling regulation? J Bone Miner Res. May 2002;17(5):907-914.
2006	Zhao C, Irie N, Takada Y, Shimoda K, Miyamoto T, Nishiwaki T, Suda T, Matsuo K. Bidirectional ephrinB2-EphB4 signaling controls bone homeostasis. Cell Metab. August 2006;4(2):111-121.