Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand

Kong, Young-Yun<sup>1</sup>; Feige, Ulrich<sup>2</sup>; Sarosi, Iidiko<sup>3</sup>; Bolon, Brad<sup>3</sup>; Tafuri, Anna<sup>1</sup>; Morony, Sean<sup>3</sup>; Capparelli, Casey<sup>3</sup>; Li, Ji<sup>4</sup>; Elliott, Robin<sup>4</sup>; McCabe, Susan<sup>4</sup>; Wong, Thomas<sup>5</sup>; Campagnuolo, Giuseppe<sup>2</sup>; Moran, Erika<sup>6</sup>; Bogoch, Earl R.<sup>6</sup>; Van, Gwyneth<sup>3</sup>; Nguyen, Linh T.<sup>7</sup>; Ohashi, Pamela S.<sup>7</sup>; Lacey, David L.<sup>3</sup>; Fish, Eleanor<sup>5</sup>; Boyle, William J.<sup>4</sup>; Penninger, Josef M.<sup>1,7</sup>

¹Amgen Institute, 620 University Avenue, Toronto, Ontario M5G 2C1, Canada

²Department of Pharmacology, Amgen Inc., One Amgen Center Drive, Thousand Oaks, California 91320-1789, USA

³Department of Pathology, Amgen Inc., One Amgen Center Drive, Thousand Oaks, California 91320-1789, USA

⁴Department of Cell Biology, Amgen Inc., One Amgen Center Drive, Thousand Oaks, California 91320-1789, USA

⁵Department of Medical Genetics & Microbiology, and the Departments of Medical Biophysics and Immunology, University of Toronto, Toronto, Ontario, Canada

⁶St Michael’s Hospital, and the Departments of Medical Biophysics and Immunology, University of Toronto, Toronto, Ontario, Canada

⁷Ontario Cancer Institute and the Departments of Medical Biophysics and Immunology, University of Toronto, Toronto, Ontario, Canada

Year

Entry

1998

Lacey DL, Timms E, Tan H-L, Kelley MJ, Dunstan CR, Burgess T, Elliott R, Colombero A, Elliott G, Scully S, Hsu H, Sullivan J, Hawkins N, Davy E, Capparelli C, Eli A, Qian Y-X, Kaufman S, Sarosi I, Shalhoub V, Senaldi G, Guo J, Delaney J, Boyle WJ. Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation. Cell. April 17, 1998;93(2):165-176.

1997

Simonet WS, Lacey DL, Dunstan CR, Kelley M, Chang M-S, Lüthy R, Nguyen HQ, Wooden S, Bennett L, Boone T, Shimamoto G, DeRose M, Elliott R, Colombero A, Tan H-L, Trail G, Sullivan J, Davy E, Bucay N, Renshaw-Gegg L, Hughes TM, Hill D, Pattison W, Campbell P, Sander S, Van G, Tarpley J, Derby P, Lee R, Boyle WJ; Amgen EST Program. Osteoprotegerin: a novel secreted protein involved in the regulation of bone density. Cell. April 18, 1997;89(2):309-319.

1999

Kong Y-Y, Yoshida H, Sarosi I, Tan H-L, Timms E, Capparelli C, Morony S, Oliveira-dos-Santos AJ, Van G, Itie A, Khoo W, Wakeham A, Dunstan CR, Lacey DL, Mak TW, Boyle WJ, Penninger JM. OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis. Nature. January 28, 1999;397(6717):315-323.

Year

Entry

2020

Alder KD, Lee I, Munger AM, Kwon H-K, Morris MT, Cahill SV, Back J, Yu KE, Lee FY. Intracellular Staphylococcus aureus in bone and joint infections: a mechanism of disease recurrence, inflammation, and bone and cartilage destruction. Bone. December 2020;141:115568.

2020

Fernández-Murga ML, Olivares M, Sanz Y. Bifidobacterium pseudocatenulatum CECT 7765 reverses the adverse effects of diet-induced obesity through the gut-bone axis. Bone. December 2020;141:115580.

2022

Takegahara N, Kim H, Choi Y. RANKL biology. Bone. June 2022;159:116353.

2007

Lewiecki EM, Miller PD, McClung MR, Cohen SB, Bolognese MA, Liu Y, Wang A, Siddhanti S, Fitzpatrick LA; AMG 162 Bone Loss Study Group. Two-year treatment with denosumab (AMG 162) in a randomized phase 2 study of postmenopausal women with low BMD. J Bone Miner Res. December 2007;22(12):1832-1841.

2007

Travis N. Effects of Ionizing Radiaton on Diaphyseal Cortical Bone [Master's thesis]. Clemson, SC: Clemson University; May 2007.

2008

Willey JS. Radiation-Induced Osteoporosis: Bone Quantity, Architecture, and Increased Resorption Following Exposure to Ionizing Radiation [PhD thesis]. Clemson, SC: Clemson University; May 2008.

2013

Newa M. Antibody Mediated "Universal" Osteoclast Targeting Platform [PhD thesis]. Edmonton, AB: University of Alberta; 2013.

2004

Doschak MR. Bisphosphonate Antiresorptive Drug Use in a Rabbit Model of Osteoarthritis [PhD thesis]. Calgary, AB: University of Calgary; April 2004.

2017

Cyndari KI. Mechanisms of Aseptic Loosening in Total Knee Arthroplasty [PhD thesis]. Syracuse, NY: State University of New York Upstate Medical University; 2017.

2013

Ausk BJ. Identifying the Origins of Bone Loss Induced by Transient Muscle Paralysis Using Novel MicroCT Image Registration Techniques [PhD thesis]. University of Washington; 2013.