Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families

Suda, Tatsuo; Takahashi, Naoyuki; Udagawa, Nobuyuki; Jimi, Eijiro; Gillespie, Matthew T.; Martin, T. John

Affiliations

¹Department of Biochemistry, School of Dentistry, Showa University, Shinagawa-ku, Tokyo 142-8555, Japan

²Vincent’s Institute of Medical Research, University of Melbourne, Fitzroy, Victoria 3065, Australia

Links

DOI: 10.1210/er.20.3.345

PubMed: 10368775

WoS: 000080685500008

Cited Works (7)

Year	Entry
1998	Yasuda H, Shima N, Akagawa NN, Yamaguchi K, Kinosaki M, Mochizuki S-I, Omoyasu AT, Yano K, Goto M, Murakami A, Tsuda E, Morinaga T, Igashio KH, Udagawa N, Tkahashi N, Suda T. Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL. Proc Natl Acad Sci USA. March 31, 1998;95(7):3597-3602.
1998	Lacey DL, Timms E, Tan H-L, Kelley MJ, Dunstan CR, Burgess T, Elliott R, Colombero A, Elliott G, Scully S, Hsu H, Sullivan J, Hawkins N, Davy E, Capparelli C, Eli A, Qian Y-X, Kaufman S, Sarosi I, Shalhoub V, Senaldi G, Guo J, Delaney J, Boyle WJ. Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation. Cell. April 17, 1998;93(2):165-176.
1997	Simonet WS, Lacey DL, Dunstan CR, Kelley M, Chang M-S, Lüthy R, Nguyen HQ, Wooden S, Bennett L, Boone T, Shimamoto G, DeRose M, Elliott R, Colombero A, Tan H-L, Trail G, Sullivan J, Davy E, Bucay N, Renshaw-Gegg L, Hughes TM, Hill D, Pattison W, Campbell P, Sander S, Van G, Tarpley J, Derby P, Lee R, Boyle WJ; Amgen EST Program. Osteoprotegerin: a novel secreted protein involved in the regulation of bone density. Cell. April 18, 1997;89(2):309-319.
1981	Rodan GA, Martin TJ. Role of osteoblasts in hormonal control of bone resorption: a hypothesis. Calcif Tiss Int. December 1981;33(1):349-351.
1990	Yoshida H, Hayashi S-I, Kunisada T, Ogawa M, Nishikawa S, Okamura H, Sudo T, Shultz LD, Nishikawa S-I. The murine mutation osteopetrosis is in the coding region of the macrophage colony stimulating factor gene. Nature. May 31, 1990;345(6274):442-444.
1990	Udagawa N, Takahashi N, Akatsu T, Tanaka H, Sasaki T, Nishihara T, Koga T, Martin TJ, Suda T. Origin of osteoclasts: mature monocytes and macrophages are capable of differentiating into osteoclasts under a suitable microenvironment prepared by bone marrow-derived stromal cells. Proc Natl Acad Sci USA. September 1, 1990;87(18):7260-7264.
1999	Kong Y-Y, Yoshida H, Sarosi I, Tan H-L, Timms E, Capparelli C, Morony S, Oliveira-dos-Santos AJ, Van G, Itie A, Khoo W, Wakeham A, Dunstan CR, Lacey DL, Mak TW, Boyle WJ, Penninger JM. OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis. Nature. January 28, 1999;397(6717):315-323.

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2006	Hadjidakis DJ, Androulakis II. Bone remodeling. Annals NY Acad Sci. December 2006;1092(1):385-396.
2011	Feng X, McDonald JM. Disorders of bone remodeling. Annu Rev Pathol. 2011;6:121-145.
2020	Sims NA, Martin TJ. Osteoclasts provide coupling signals to osteoblast lineage cells through multiple mechanisms. Annu Rev Physiol. February 10, 2020;82:507-529.
2005	Keller H, Kneissel M. SOST is a target gene for PTH in bone. Bone. August 2005;37(2):148-158.
2020	Sugisaki R, Miyamoto Y, Yoshimura K, Sasa K, Kaneko K, Tanaka M, Itose M, Inoue S, Baba K, Shirota T, Chikazu D, Kamijo R. Possible involvement of elastase in enhanced osteoclast differentiation by neutrophils through degradation of osteoprotegerin. Bone. March 2020;132:115216.
2021	Moussa FM, Cook BP, Sondag GR, DeSanto M, Obri MS, McDermott SE, Safadi FF. The role of miR-150 regulates bone cell differentiation and function. Bone. April 2021;145:115470.
2021	Zhao L, Ito S, Arai A, Udagawa N, Horibe K, Hara M, Nishida D, Hosoya A, Masuko R, Okabe K, Shin M, Li X, Matsuo K, Abe S, Matsunaga S, Kobayashi Y, Kagami H, Mizoguchi T. Odontoblast death drives cell-rich zone-derived dental tissue regeneration. Bone. September 2021;150:116010.
2024	Cramer EEA, de Wildt BWM, Hendriks JGE, Ito K, Hofmann S. Integration of osteoclastogenesis through addition of PBMCs in human osteochondral explants cultured ex vivo. Bone. January 2024;178:116935.
2014	Sims NA, Martin TJ. Coupling the activities of bone formation and resorption: a multitude of signals within the basic multicellular unit. BoneKEy Rep. January 2014;3:481.
2020	Xin Y, Liu Y, Liu D, Li J, Zhang C, Wang Y, Zheng S. New function of RUNX2 in regulating osteoclast differentiation via the AKT/NFATc1/CTSK axis. Calcif Tiss Int. May 2020;106(5):553-566.
2000	Ducy P, Amling M, Takeda S, Priemel M, Schilling AF, Beil FT, Shen J, Vinson C, Rueger JM, Karsenty G. Leptin inhibits bone formation through a hypothalamic relay: a central control of bone mass. Cell. January 21, 2000;100(2):197-207.
2002	Karsenty G, Wagner EF. Reaching a genetic and molecular understanding of skeletal development. Dev Cell. April 2002;2(4):389-406.
2002	Takayanagi H, Kim S, Koga T, Nishina H, Isshiki M, Yoshida H, Saiura A, Isobe M, Yokochi T, Inoue J-i, Wagner EF, Mak TW, Kodama T, Taniguchi T. Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts. Dev Cell. December 1, 2002;3(6):889-901.
2000	Manolagas SC. Birth and death of bone cells: basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis. Endocr Rev. April 2000;21(2):115-137.
2002	Riggs BL, Khosla S, Melton LJ III. Sex steroids and the construction and conservation of the adult skeleton. Endocr Rev. June 2002;23(3):279-302.
2008	Kogianni G, Mann V, Noble BS. Apoptotic bodies convey activity capable of initiating osteoclastogenesis and localized bone destruction. J Bone Miner Res. June 2008;23(6):915-927.
2020	Eckhardt BA, Rowsey JL, Thicke BS, Fraser DG, O’Grady KL, Bondar OP, Hines JM, Singh RJ, Thoreson AR, Rakshit K, Lagnado AB, Passos JF, Vella A, Matveyenko AV, Khosla S, Monroe DG, Farr JN. Accelerated osteocyte senescence and skeletal fragility in mice with type 2 diabetes. JCI Insight. May 7, 2020;5(9):135236.
2003	Eghbali-Fatourechi G, Khosla S, Sanyal A, Boyle WJ, Lacey DL, Riggs BL. Role of RANK ligand in mediating increased bone resorption in early postmenopausal women. J Clin Invest. April 2003;111(8):1221-1230.
2005	Raisz LG. Pathogenesis of osteoporosis: concepts, conflicts, and prospects. J Clin Invest. December 2005;115(12):3318-3325.
2002	Seeman E. Pathogenesis of bone fragility in women and men. Lancet. May 25, 2002;359(9320):1841-1850.
2020	Koide M, Yamashita T, Murakami K, Uehara S, Nakamura K, Nakamura M, Matsushita M, Ara T, Yasuda H, Penninger JM, Takahashi N, Udagawa N, Kobayashi Y. Sclerostin expression in trabecular bone is downregulated by osteoclasts. Sci Rep. 2020;10:13751.
2006	Bolland MJ. Studies of the Pathogenesis and Treatment of Secondary Osteoporosis [PhD thesis]. Auckland, New Zealand: University of Auckland; 2006.
2007	Yuan Y. The Differential Effects of Two Critical Osteoclastogenesis Stimulating Factors on Bone Biomechanics [PhD thesis]. Clemson, SC: Clemson University; May 2007.
2008	Willey JS. Radiation-Induced Osteoporosis: Bone Quantity, Architecture, and Increased Resorption Following Exposure to Ionizing Radiation [PhD thesis]. Clemson, SC: Clemson University; May 2008.
2017	Bowman LC. Whole Body Irradiation and Degradation of Structural and Functional Properties of Mouse Bone: X-Rays, Protons, and Heavy Ions [PhD thesis]. Clemson, SC: Clemson University; December 2017.
2014	Lee HG. Innate Immune-Like Function of Osteogenic Cells and Their Effects on Inflammatory Osteolysis [PhD thesis]. Columbia University; 2014.
2019	Bakr M. Parathyroid Hormone Effect on Facilitating Stress Fracture Repair [PhD thesis]. Brisbane, Australia: Griffith University; July 2019.
2023	Nilsson K. NOTUM and RSPO3 in Bone: WNT Signaling Modulators Regulating the Skeleton [PhD thesis]. University of Gothenburg; 2023.
2006	Sumanasinghe RD. Functional Bone Tissue Engineering Using Human Mesenchymal Stem Cells and Polymeric Scaffolds [PhD thesis]. North Carolina State University; 2006.
2017	Kreipke TC. Structural, Mechanical, and Biological Relationships of Trabecular Bone in Osteoporosis [PhD thesis]. University of Notre Dame; April 2017.
2014	Bradke BS. The Role of Cortical and Cancellous Bone Quality on Vertebral Fragility [PhD thesis]. Troy, NY: Rensselaer Polytechnic Institute; April 2014.
2016	Wittkowske C. The Role of Mechanical Forces in Bone Formation: Evaluation of Long-Term Responses by Osteoblasts to Low Fluid Shear Stress in Vitro [PhD thesis]. University of Sheffield; September 2016.
2006	Garman RA. Low-Level Accelerations Applied in the Absence of Weight Bearing Can Alter Cellular Activity and Tissue Morphology in the Skeleton [PhD thesis]. Stony Brook, NY: Stony Brook University; May 2006.
2008	Mulvihill BMC. Computational Investigation Into the Mechanoregulation of Osteoporosis [PhD thesis]. Trinity College Dublin; December 2008.
2011	Lam MCW. Single Chain Fraction Variable Binding Molecules as Bone-Targeting Therapeutics and Diagnostics [Master's thesis]. Edmonton, AB: University of Alberta; 2011.
2018	Tang KC-C. Role of FoxO3a in Osteoblast Differentiation and Matrix Calcification [PhD thesis]. Edmonton, AB: University of Alberta; 2018.
2013	Fowler TW. Activin Regulation of Osteoclast Formation, Motility, Function, and Survival [PhD thesis]. University of Arkansas for Medical Sciences; 2013.
2019	Wong S-W. The Role of Autophagy Machinery in Osteoclast Disease Pathogenesis [PhD thesis]. University of North Carolina at Chapel Hill; 2019.
2016	Takyar F. Osteoblastic EphrinB2 in Normal and Parathyroid Hormone (PTH)-Stimulated Bone Formation [PhD thesis]. University of Melbourne; June 2016.
2018	Ansari N. Physiological Role of Osteocytic Parathyroid Hormone-Related Protein (PTHrP) [PhD thesis]. University of Melbourne; June 2018.
2010	Magalhaes JKRS. The Role of Rac1 and Rac2 in Determining Bone Quality in Aged and Osteoporotic Female Mouse Models [Master's thesis]. University of Toronto; 2010.
2022	Luo TD. The Effects of Ascorbic Acid in the Treatment of Radiation-Induced Bone Damage [PhD thesis]. Winston-Salem, NC: Wake Forest University; September 2022.