Bone remodeling and bone loss:​ understanding the pathophysiology of osteoporosis

Parfitt, A. M.

Affiliations

¹Henry Ford Hospital Detroit, Michigan

Links

DOI: 10.1097/00003081-198712000-00004

PubMed: 3319313

WoS: A1987L278900002

Cited Works (9)

Year	Entry
1986	Eriksen EF. Normal and pathological remodeling of human trabecular bone: three dimensional reconstruction of the remodeling sequence in normals and in metabolic bone disease. Endocr Rev. November 1986;7(4):379-408.
1987	Parfitt AM. Trabecular bone architecture in the pathogenesis and prevention of fracture. Am J Med. January 26, 1987;82(suppl 1B):68-72.
1984	Parfitt AM. Age-related structural changes in trabecular and cortical bone: cellular mechanisms and biomechanical consequences. Calcif Tiss Int. 1984;36(suppl 1):S123-S128.
1985	Frost HM. The pathomechanics of osteoporoses. Clin Orthop Relat Res. November 1985;200:198-225.
1984	Parfitt AM. The cellular basis of bone remodeling: the quantum concept reexamined in light of recent advances in the cell biology of bone. Calcif Tiss Int. March 1984;36(suppl 1):S37-S45.
1985	Cummings SR, Kelsey JL, Nevitt MC, O'Dowd KJ. Epidemiology of osteoporosis and osteoporotic fractures. Epidemiol Rev. 1985;7:178-208.
1985	Kleerekoper M, Villanueva AR, Stanciu J, Rao DS, Parfitt AM. The role of three-dimensional trabecular microstructure in the pathogenesis of vertebral compression fractures. Calcif Tiss Int. 1985;37(6):594-597.
1982	Genant HK, Cann CE, Ettinger B, Gordan GS. Quantitative computed tomography of vertebral spongiosa: a sensitive method for detecting early bone loss after oophorectomy. Ann Intern Med. 1982;97(5):699-705.
1982	Krølner B, Pors Nielsen S. Bone mineral content of the lumbar spine in normal and osteoporotic women: cross-sectional and longitudinal studies. Clin Sci (London). March 1982;62(3):329-336.

Cited By (26)

Year	Entry
1995	Oxlund H, Barckman M, Ørtoft G, Andreassen TT. Reduced concentrations of collagen cross-links are associated with reduced strength of bone. Bone. October 1995;17(4)(suppl):S365-S371.
1996	Oxlund H, Mosekilde L, Ørtoft G. Reduced concentration of collagen reducible cross links in human trabecular bone with respect to age and osteoporosis. Bone. November 1996;19(5):479-484.
2006	Nyman JS, Roy A, Acuna RL, Gayle HJ, Reyes MJ, Tyler JH, Dean DD, Wang X. Age-related effect on the concentration of collagen crosslinks in human osteonal and interstitial bone tissue. Bone. December 2006;39(6):1210-1217.
2007	Diab T, Vashishth D. Morphology, localization and accumulation of in vivo microdamage in human cortical bone. Bone. March 2007;40(3):612-618.
2021	Paschalis EP, Dempster DW, Gamsjaeger S, Rokidi S, Hassler N, Brozek W, Chan-Diehl FW, Klaushofer K, Taylor KA. Mineral and organic matrix composition at bone forming surfaces in postmenopausal women with osteoporosis treated with either teriparatide or zoledronic acid. Bone. April 2021;145:115848.
2022	Megías R, Vercher-Martínez A, Belda R, Peris JL, Larrainzar-Garijo R, Giner E, Fuenmayor FJ. Numerical modelling of cancellous bone damage using an orthotropic failure criterion and tissue elastic properties as a function of the mineral content and microporosity. Comput Methods Prog Biomed. June 2022;219:106764.
1994	Hollister SJ, Brennan JM, Kikuchi N. A homogenization sampling procedure for calculating trabecular bone effective stiffness and tissue level stres. J Biomech. 1994;27(4):433-444.
2002	Jaasma MJ, Bayraktar HH, Niebur GL, Keaveny TM. Biomechanical effects of intraspecimen variations in tissue modulus for trabecular bone. J Biomech. 2002;35(2):237-246.
1995	Kohrt WM, Snead DB, Slatopolsky E, Birge SJ Jr. Additive effects of weight-bearing exercise and estrogen on bone mineral density in older women. J Bone Miner Res. September 1995;10(9):1303-1311.
2008	Fuchs RK, Allen MR, Ruppel ME, Diab T, Phipps RJ, Miller LM, Burr DB. In situ examination of the time-course for secondary mineralization of Haversian bone using synchrotron Fourier transform infrared microspectroscopy. Matrix Biol. January 2008;27(1):34-41.
2013	Paietta RC. Microscale Material Properties of Bone and the Mineralized Tissues of the Intervertebral Disc-Vertebral Body Interface [PhD thesis]. Boulder, CO: University of Colorado; 2013.
2006	Nagaraja S. Microstructural Stresses and Strains Associated With Trabecular Bone Microdamage [PhD thesis]. Atlanta, GA: Georgia Institute of Technology; December 2006.
1997	Heinonen A. Exercise as an Osteogenic Stimulus [PhD thesis]. University of Jyväskylä; 1997.
2016	Metzger TA. Experimental and Computational Investigation of Bone Marrow Mechanobiology [PhD thesis]. University of Notre Dame; April 2016.
2013	Verbruggen SW. Mechanobiological Origins of Osteoporosis [PhD thesis]. National University of Ireland Galway; September 2013.
1992	Bloomfield SA. Site-Specific Changes in Bone Mass and Alterations in Calciotropic Hormones With Electrical Stimulation Exercise in Individuals With Chronic Spinal Cord Injury [PhD thesis]. The Ohio State University; 1992.
2006	Diab T. The Role of Damage Morphology in Age-Related Increase in Bone Fragility [PhD thesis]. Troy, NY: Rensselaer Polytechnic Institute; 2006.
2009	Ruppel ME. Alterations in the Mineral and Collagen Matrix of Bisphosphonate-Treated Bone and Osteoblasts [PhD thesis]. Stony Brook, NY: Stony Brook University; May 2009.
2006	Gleeson JP. Composition and Mechanical Properties of Osteoarthritic Subchondral Trabecular Tibial Bone [PhD thesis]. Trinity College Dublin; November 2006.
2003	Bayraktar HH. Multiaxial Strength and Micromechanics of Human Bone [PhD thesis]. Berkeley, CA: Berkeley, University of California; 2003.
2003	Fox JC. Biomechanics of the Proximal Femur: Role of Bone Distribution and Architecture [PhD thesis]. Berkeley, CA: Berkeley, University of California; 2003.
2014	Nawathe S. Micromechanics of the Human Proximal Femur: Role of Microstructure and Tissue-Level Ductility on Femoral Strength [PhD thesis]. Berkeley, CA: Berkeley, University of California; 2014.
1991	Hollister SJ. Homogenization Analysis of Trabecular Bone and Prediction Ofbone Ingrowth Using Topology Optimization [PhD thesis]. University of Michigan; 1991.
1995	Guldberg RE. Mechanical Adaptation of Trabecular Bone Formation in Vivo [PhD thesis]. University of Michigan; 1995.
1997	Richards M. Strain Environment Effects on New Bone Formation and Precursor Tissue Differentiation During Distraction [PhD thesis]. University of Michigan; 1997.
2010	Hughes JM. Revisiting Harold Frost's Mechanostat Theory of Bone Functional Adaptation: New Interpretations Based on New Evidence [PhD thesis]. University of Minnesota; December 2010.