The mechanical properties of bone in osteoporosis

Dickenson, R. P.<sup>1</sup>; Hutton, W. C.<sup>1</sup>; Stott, J. R. R.<sup>2</sup>

Affiliations

¹Polytechnic of Central London, 115 New Cavendish Street, London W1M 8JS, England

²Research Medical Officer, RAF Institute of Aviation Medicine, Farnborough, Hampshire, England

Abstract

Specimens of femoral cortical bone from normal subjects and from patients with osteoporosis were mechanically tested in tension to destruction. The osteoporotic bone showed less strength and less stiffness than the normal bone; these reductions are related to the increased cavity area in osteoporosis. Further, the osteoporotic bone is not able to absorb as much energy before fracture as the normal bone; but this difference is not related to changes in cavity area.

Links

DOI: 10.1302/0301-620X.63B2.7217148

PubMed: 7217148

WoS: A1981LQ20700015

Cited Works (7)

Year	Entry
1971	Swanson SAV, Freeman MAR, Day WH. The fatigue properties of human cortical bone. Med Biol Eng. January 1971;9(1):23-32.
1973	Piekarski K. Analysis of bone as a composite material. Int J Eng Sci. June 1973;11(6):557-565.
1974	Reilly DT, Burstein AH. The mechanical properties of cortical bone. J Bone Joint Surg. 1974;56A(5):1001-1022.
1975	Burstein AH, Zika JM, Heiple KG, Klein L. Contribution of collagen and mineral to the elastic-plastic properties of bone. J Bone Joint Surg. October 1975;57A(7):956-961.
1973	Evans FG. Mechanical Properties of Bone. Springfield, IL: Charles C. Thomas; 1973.
1976	Burstein AH, Reilly DT, Martens M. Aging of bone tissue: mechanical properties. J Bone Joint Surg. 1976;58A(1):82-86.
1970	Currey JD. The mechanical properties of bone. Clin Orthop Relat Res. November–December 1970;73:210-231.

Cited By (46)

Year	Entry
1986	Frost HM. Intermediary Organization of the Skeleton. Vols. 1-2. Boca Raton, FL: CRC Press; 1986.
1985	Mosekilde L, Viidik A, Mosekilde L. Correlation between the compressive strength of iliac and vertebral trabecular bone in normal individuals. Bone. 1985;6(5):291-295.
1999	Bell KL, Loveridge N, Power J, Garrahan N, Meggitt BF, Reeve J. Regional differences in cortical porosity in the fractured femoral neck. Bone. January 1999;24(1):57-64.
2000	Jordan GR, Loveridge N, Bell KL, Power J, Rushton N, Reeve J. Spatial clustering of remodeling osteons in the femoral neck cortex: a cause of weakness in hip fracture? Bone. March 2000;26(3):305-313.
2002	Burr DB. The contribution of the organic matrix to bone's material properties. Bone. July 2002;31(1):8-11.
2003	Burr DB, Miller L, Grynpas M, Li J, Boyde A, Mashiba T, Hirano T, Johnston CC. Tissue mineralization is increased following 1-year treatment with high doses of bisphosphonates in dogs. Bone. December 2003;33(6):960-969.
2006	McNamara LM, Ederveen AGH, Lyons CG, Price C, Schaffler MB, Weinans H, Prendergast PJ. Strength of cancellous bone trabecular tissue from normal, ovariectomized and drug-treated rats over the course of ageing. Bone. August 2006;39(2):392-400.
2020	Loundagin LL, Haider IT, Cooper DML, Edwards WB. Association between intracortical microarchitecture and the compressive fatigue life of human bone: a pilot study. Bone Rep. June 2020;12:100254.
1990	Mazess RB. Fracture risk: a role for compact bone. Calcif Tiss Int. October 1990;47(4):191-193.
1993	Parfitt AM. Bone age, mineral density, and fatigue damage. Calcif Tiss Int. February 1993;53(suppl 1):S82-S86.
1993	Squillante RG, Williams JL. Videodensitometry of osteons in females with femoral neck fractures. Calcif Tiss Int. April 1993;52(4):273-277.
1985	Melton LJ, Riggs BL. Risk factors for injury after a fall. Clin Geriatr Med. August 1985;1(3):525-539.
1992	Barth RW, Williams JL, Kaplan FS. Osteon morphometry in females with femoral neck fractures. Clin Orthop Relat Res. October 1992;283:178-186.
1993	Bailey AJ, Wotton SF, Sims TJ, Thompson PW. Biochemical changes in the collagen of human osteoporotic bone matrix. Connect Tissue Res. 1993;29(2):119-132.
2005	Kristen K-H, Berger K, Berger C, Kampla W, Anzböck W, Weitzel SH. The first metatarsal bone under loading conditions: a finite element analysis. Foot and Ankle Clinics. 2005;10(1):1-14.
2005	Thomas CDL, Feik SA, Clement JG. Regional variation of intracortical porosity in the midshaft of the human femur: age and sex differences. J Anat. February 2005;206(2):115-125.
2006	Thomas CDL, Feik SA, Clement JG. Increase in pore area, and not pore density, is the main determinant in the development of porosity in human cortical bone. J Anat. August 2006;209(2):219-230.
1991	Lotz JC, Gerhart TN, Hayes WC. Mechanical properties of metaphyseal bone in the proximal femur. J Biomech. 1991;24(5):317-329.
2011	Brennan O, Kennedy OD, Lee TC, Rackard SM, O’Brien FJ, McNamara LM. The effects of estrogen deficiency and bisphosphonate treatment on tissue mineralisation and stiffness in an ovine model of osteoporosis. J Biomech. February 3, 2011;44(3):386-390.
2020	Gluek C, Zdero R, Quenneville CE. Evaluating the mechanical response of novel synthetic femurs for representing osteoporotic bone. J Biomech. October 9, 2020;111:110018.
2001	Bousson V, Meunier A, Bergot C, Vicaut É, Rocha MA, Morais MH, Laval‐Jeantet A, Laredo J. Distribution of intracortical porosity in human midfemoral cortex by age and gender. J Bone Miner Res. July 2001;16(7):1308-1317.
2007	Schneider P, Stauber M, Voide R, Stampanoni M, Donahue LR, Müller R. Ultrastructural properties in cortical bone vary greatly in two inbred strains of mice as assessed by synchrotron light based micro‐ and nano‐CT. J Bone Miner Res. October 2007;22(10):1557-1570.
2012	Vaughan TJ, McCarthy CT, McNamara LM. A three-scale finite element investigation into the effects of tissue mineralisation and lamellar organisation in human cortical and trabecular bone. J Mech Behav Biomed Mater. August 2012;12:50-62.
2021	Mohammadi H, Pietruszczak S, Quenneville CE. Numerical analysis of hip fracture due to a sideways fall. J Mech Behav Biomed Mater. March 2021;115:104283.
1988	Ruff CB, Hayes WC. Sex differences in age‐related remodeling of the femur and tibia. J Orthop Res. November 1988;6(6):886-896.
2009	Fritsch A, Hellmich C, Dormieux L. Ductile sliding between mineral crystals followed by rupture of collagen crosslinks: experimentally supported micromechanical explanation of bone strength. J Theo Biol. September 21, 2009;260(2):230-252.
2012	Russell NA, Pelletier MH, Bruce WJ, Walsh WR. The effect of gamma irradiation on the anisotropy of bovine cortical bone. Med Eng Phys. October 2012;34(8):1117-1122.
1995	Lotz JC, Cheal EJ, Hayes WC. Stress distributions within the proximal femur during gait and falls: implications for osteoporotic fracture. Osteoporos Int. July 1995;5(3):252-261.
2004	Wegst UGK, Ashby MF. The mechanical efficiency of natural materials. Philos Mag. July 21, 2004;84(21):2167-2181.
2007	Schneider P. Ultrastructural Phenotyping of Murine Bone Using Synchrotron Micro- and Nano-Computed Tomography [PhD thesis]. Swiss Federal Institute of Technology Zürich; 2007.
2019	Groetsch A. Micro- and Nanomechanics of Mineralised Collagen Fibre Elasto-Plasticity [PhD thesis]. Ebinburgh, Scotland: Heriot-Watt University; November 2019.
2000	Richman CC. In Vitro and in Vivo Studies on Bone Formation [PhD thesis]. Loma Linda University; March 2000.
2018	Gluek C. Evaluating the Mechanical Response of Novel Synthetic Femurs Representing Osteoporotic Bone [Master's thesis]. Hamilton, ON: McMaster University; August 2018.
1988	Lotz JC. Hip Fracture Risk Predictions by X-Ray Computed Tomography [PhD thesis]. Cambridge, MA: Massachusetts Institute of Technology; August 1988.
2013	Verbruggen SW. Mechanobiological Origins of Osteoporosis [PhD thesis]. National University of Ireland Galway; September 2013.
2020	Simfia I. Estrogen Deficiency Alters the Mechanobiological Responses of Osteoblasts and Osteocytes [PhD thesis]. National University of Ireland Galway; April 2020.
2020	Karali A. Multi-Scale Evaluation of Bone Combining Indentation, in Situ XCT Mechanics and Digital Volume Correlation [PhD thesis]. Portsmouth, England: University of Portsmouth; 2020.
2013	Morton JJ. An Investigation of Rat Vertebra Failure Behaviour Under Uniaxial Compression Through Time-Lapsed Micro-CT Imaging [Master's thesis]. Queen's University; 2013.
2012	Brennan MA. Close to the Bone: Investigations Into Bone Tissue Mineralisation and Mechanobiology of Osteoporosis [PhD thesis]. University of Southampton; January 2012.
2004	McNamara LM. Biomechanical Origins of Osteoporosis [PhD thesis]. Trinity College Dublin; March 2004.
2008	Mulvihill BMC. Computational Investigation Into the Mechanoregulation of Osteoporosis [PhD thesis]. Trinity College Dublin; December 2008.
2020	Loundagin LL. The Influence of Intracortical Microarchitecture on the Mechanical Fatigue of Bone [PhD thesis]. Calgary, AB: University of Calgary; July 2020.
2013	Liao L. Magnetic Resonance Imaging of Proximal Femur and Surrounding Muscles: in Vivo Precision [Master's thesis]. University of Saskatchewan; September 2013.
1998	Vajda EG. Age-Related Changes in the Microstructure and Mineralization of the Female Proximal Femur [PhD thesis]. University of Utah; March 1998.
2007	Rosenbaum TG. Effects of a Femoral Component and Patient Factors on Periprosthetic Cortical Bone [PhD thesis]. University of Utah; May 2007.
2017	Gooding AF. Variation in Cortical Bone Distribution in the Aging Adult Appendicular Skeleton [PhD thesis]. Knoxville, University of Tennessee; December 2017.