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Ritchie, Rob
1,2
;
Buehler, Markus
3
;
Hansma, Paul
4
Plasticity and toughness in bone
Phys Today
. June 2009;62(6):41-47
©2009 American Institute of Physics
Affiliations
1
University of California, Berkeley
2
Lawrence Berkeley National Laboratory
3
Massachusetts Institute of Technology
in Cambridge
4
University of California, Santa Barbara
Abstract
Our bones are full of microscopic cracks, but the hierarchical character of the bones’ structure—from molecular to macroscopic scales—makes them remarkably resistant to fracture.
Links
DOI:
10.1063/1.3156332
WoS:
000266965300020
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Nalla RK, Kinney JH, Ritchie RO. Mechanistic fracture criteria for the failure of human cortical bone.
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Nalla RK, Kruzic JJ, Kinney JH, Ritchie RO. Effect of aging on the toughness of human cortical bone: evaluation by R-curves.
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2013
Pechníková M.
Forensic Analysis of Bone Fractures Caused by Blunt Force Trauma
[PhD thesis]. Brno, Czech Republic: Masaryk University; 2013.
2011
Wang R, Gupta HS. Deformation and fracture mechanisms of bone and nacre.
Ann Rev Mater Res
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2018
Nelms MD, Hodo WD, Rajendran AM. Bioinspired layered composite principles of biomineralized fish scale. In: Gopalakrishnan S, Rajapaks Y, eds.
Blast Mitigation Strategies in Marine Composite and Sandwich Structures
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Springer Transactions in Civil and Environmental Engineering
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2021
Casari D, Michler J, Zysset P, Schwiedrzik J. Microtensile properties and failure mechanisms of cortical bone at the lamellar level.
Acta Biomater
. January 15, 2021;120:135-145.
2010
Launey ME, Chen P-Y, McKittrick J, Ritchie RO. Mechanistic aspects of the fracture toughness of elk antler bone.
Acta Biomater
. April 2010;6(4):1505-1514.
2022
Micheletti C, Hurley A, Gourrier A, Palmquist A, Tang T, Shah FA, Grandfield K. Bone mineral organization at the mesoscale: a review of mineral ellipsoids in bone and at bone interfaces.
Acta Biomater
. April 1, 2022;142:1-13.
2017
Smolen C, Quenneville CE. A finite element model of the foot/ankle to evaluate injury risk in various postures.
Ann Biomed Eng
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2010
Launey ME, Buehler MJ, Ritchie RO. On the mechanistic origins of toughness in bone.
Ann Rev Mater Sci
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2011
Barth HD, Zimmermann EA, Schaible E, Tang SY, Alliston T, Ritchie RO. Characterization of the effects of x-ray irradiation on the hierarchical structure and mechanical properties of human cortical bone.
Biomaterials
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2010
Barth HD, Launey ME, MacDowell AA, Ager JW III, Ritchie RO. On the effect of X-ray irradiation on the deformation and fracture behavior of human cortical bone.
Bone
. June 2010;46(6):1475-1485.
2021
Loundagin LL, Pohl AJ, Edwards WB. Stressed volume estimated by finite element analysis predicts the fatigue life of human cortical bone: the role of vascular canals as stress concentrators.
Bone
. February 2021;143:115647.
2020
Loundagin LL, Haider IT, Cooper DML, Edwards WB. Association between intracortical microarchitecture and the compressive fatigue life of human bone: a pilot study.
Bone Rep
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2017
Rodriguez-Florez N, Carriero A, Shefelbine SJ. The use of XFEM to assess the influence of intra-cortical porosity on crack propagation.
Comput Methods Biomech Biomed Eng
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2020
Dapaah D, Badaoui R, Bahmani A, Montesano J, Willett T. Modelling the micro-damage process zone during cortical bone fracture.
Eng Fract Mech
. February 1, 2020;224:106811.
2015
Goda I, Ganghoffer J-F. 3D plastic collapse and brittle fracture surface models of trabecular bone from asymptotic homogenization method.
Int J Eng Sci
. February 2015;87:58-82.
2020
Mirzaali MJ, Libonati F, Böhm C, Rinaudo L, Cesana BM, Ulivieri FM, Vergani L. Fatigue-caused damage in trabecular bone from clinical, morphological and mechanical perspectives.
Int J Fatigue
. April 2020;133:105451.
2011
Pechníková M, Porta D, Cattaneo C. Distinguishing between perimortem and postmortem fractures: are osteons of any help?
Int J Legal Med
. July 2011;125(4):591-595.
2010
Diez‐Perez A, Güerri R, Nogues X, Cáceres E, Peña MJ, Mellibovsky L, Randall C, Bridges D, Weaver JC, Proctor A, Brimer D, Koester KJ, Ritchie RO, Hansma PK. Microindentation for in vivo measurement of bone tissue mechanical properties in humans.
J Bone Miner Res
. 2010;25(8):1877-1885.
2015
Granke M, Makowski AJ, Uppuganti S, Does MD, Nyman JS. Identifying novel clinical surrogates to assess human bone fracture toughness.
J Bone Miner Res
. July 2015;30(7):1290-1300.
2020
Maghsoudi-Ganjeh M, Wang X, Zeng X. Computational investigation of the effect of water on the nanomechanical behavior of bone.
J Mech Behav Biomed Mater
. January 2020;101:103454.
2020
Katzenberger MJ, Albert DL, Agnew AM, Kemper AR. Effects of sex, age, and two loading rates on the tensile material properties of human rib cortical bone.
J Mech Behav Biomed Mater
. February 2020;102:103410.
2020
Obata Y, Bale HA, Barnard HS, Parkinson DY, Alliston T, Acevedo C. Quantitative and qualitative bone imaging: a review of synchrotron radiation microtomography analysis in bone research.
J Mech Behav Biomed Mater
. October 2020;110:103887.
2021
Karali A, Kao AP, Zekonyte J, Blunn G, Tozzi G. Micromechanical evaluation of cortical bone using in situ XCT indentation and digital volume correlation.
J Mech Behav Biomed Mater
. March 2021;115:104298.
2011
Barthelat F, Rabie R. Toughness amplification in natural composites.
J Mech Phys Solids
. April 2011;59(4):829-840.
2020
Zhai X, Nie Y, Gao J, Kedir N, Claus B, Sun T, Fezzaa K, Chen WW. The effect of loading direction on the fracture behaviors of cortical bone at a dynamic loading rate.
J Mech Phys Solids
. September 2020;142:104015.
2020
Hart NH, Newton RU, Tan2 J, Rantalainen T, Chivers P, Siafarikas A, Nimphius S. Biological basis of bone strength: anatomy, physiology and measurement.
J Musculoskel Neuron Interact
. September 2020;20(3):347-371.
2023
Crocker DB, Hoffman I, Carter JLW, Akkus O, Rimnac CM. Fatigue crack propagation and fracture toughness of cortical bone are radiation dose-dependent.
J Orthop Res
. April 2023;41(4):823-833.
2011
Zimmermann EA, Schaible E, Bale H, Barth HD, Tang SY, Reichert P, Busse B, Alliston T, Ager JW III, Ritchie RO. Age-related changes in the plasticity and toughness of human cortical bone at multiple length scales.
Proc Natl Acad Sci USA
. August 30, 2011;108(35):14416-14421.
2016
Torres AM, Matheny JB, Keaveny TM, Taylor D, Rimnac CM, Hernandez CJ. Material heterogeneity in cancellous bone promotes deformation recovery after mechanical failure.
Proc Natl Acad Sci USA
. March 15, 2016;113(11):2892-2897.
2020
Aggleton J.
First-Hand Experience: A Methodology for Exploring Bone Architecture
[PhD thesis]. Bristol, UK: University of Bristol; January 2020.
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Small-Scale Deformation and Fracture of Hard Biomaterials
[PhD thesis]. Pasadena, CA: California Institute of Technology; 2019.
2015
Goff M.
The Role of Micro and Ultra-Structure in Microdamage Accumulation in Cancellous Bone
[PhD thesis]. Ithaca, NY: Cornell University; August 2015.
2017
Matheny JB.
Interactions Between Bone Remodeling and Microdamage in Cancellous Bone
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2018
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Fatigue Behavior of Cancellous Bone, Microdamage Accumulation, and Biologically Inspired Cellular Solids
[PhD thesis]. Ithaca, NY: Cornell University; August 2018.
2023
Maghami E.
Fracture Micromechanics Analyses of Hard Tissues: Study of Increased Glycation Through Diabetes and Age-Related Changes
[PhD thesis]. Drexel University; January 2023.
2023
Micheletti C.
Multimodal and Multiscale Characterization of Bone and Bone Interfaces in Health and Disease
[PhD thesis]. University of Gothenburg; 2023.
2012
Hamed E.
Multiscale Modeling of Elastic Moduli and Strength of Bone
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2014
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Electron Microscopy Characterisation of in Vivo Collagen and Mineral Ultra-Structures, Their Development and Pathologies
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2015
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2014
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Characterization of Bone Material Properties and Microstructure in Osteogenesis Imperfecta/brittle Bone Disease
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2017
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Multi-Dimensional Characterization of Bone and Bone-Implant Interfaces
[PhD thesis]. Hamilton, ON: McMaster University; December 2017.
2010
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[PhD thesis]. Cambridge, MA: Massachusetts Institute of Technology; September 2010.
2019
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Multiscale Characteristics of Bone Toughness
[PhD thesis]. Northeastern University; July 2019.
2012
Deymier-Black AC.
Study of the Elasto-Plastic Properties of Mineralized Biomaterials Via Synchrotron High-Energy X-Ray Diffraction
[PhD thesis]. Evanston, IL: Northwestern University; June 2012.
2013
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Mechanobiological Origins of Osteoporosis
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2017
Crowe NM.
Histomorphometric Analysis of Elderly Ribs At Various Locations
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2018
Dominguez VM.
Defining Bone Quality: Cortical Microdamage and Its Contribution to Fracture Risk in the Human Rib
[PhD thesis]. The Ohio State University; 2018.
2020
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Multi-Scale Evaluation of Bone Combining Indentation, in Situ XCT Mechanics and Digital Volume Correlation
[PhD thesis]. Portsmouth, England: University of Portsmouth; 2020.
2018
Driver MG.
Finite Element Analysis of Cortical Shell Contributions to Apparent Stiffness and the Effect of Vascular Apertures in Rat Vertebrae Under Uniaxial Compression
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2016
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2017
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Tissue Engineering an in Vitro Model of Osteoporosis
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2012
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2020
Lamprecht A.
Effect of Osmotic Pressure on the Viscoelastic Properties of Cortical Bone
[Master's thesis]. Vienna University of Technology; 2020.
2020
Loundagin LL.
The Influence of Intracortical Microarchitecture on the Mechanical Fatigue of Bone
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2011
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A Hierarchical Approach to Characterizing the Fracture Behavior of Bone Utilizing Synchrotron Radiation
[PhD thesis]. Berkeley, CA: Berkeley, University of California; F 2011.
2011
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Deformation and Fracture of Human Cortical Bone Across Multiple Length-Scales
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2012
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Not Tough Enough: Why Bone Turns Pale When it Feels Stressed
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2012
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Bone Quality of Patients With Atypical Fractures and Severely Suppressed Bone Turnover
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2013
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Multi-Level Micromechanical Modeling of Bone Tissues
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2019
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Multiscale Network Characterization of the Strength and Robustness of Trabecular Bone
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Effect of Clinically Relevant Alterations of Mineral and Protein on Bone Biomechanics
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2021
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Multi-Scale Finite Element Modelling of Human Cortical Bone: An Analysis of the Mechanical Properties and Microdamage Onset of Cortical Bone
[PhD thesis]. University of New South Wales; April 2021.
2020
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[PhD thesis]. Knoxville, University of Tennessee; August 2020.
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