In several laboratories in Europe experimental reconstructions of real accidents have been carried out during the last five years to determine and evaluate human tolerance limits. In these studies injuries arising from real accidents are compared with measured data on cadavers and dummies. In addition to this experimental research a new approach will be presented in which the behaviour of vehicle occupants is simulated using the MADYMO Crash Victim Simulator. Both the dummy and cadaver reconstructions are mathematically simulated. Furthermore a mathematical simulation is carried out to predict the behaviour of,the driver in the real accident. It is concluded that the mathematical model provides better insight into several aspects of this complex system. Therefore in addition to cadaver and dummy reconstructions a mathematical model is found to be a valuable tool for the analysis of real frontal collisions.