Within the framework of "in-depth investigations",accidents of motorized and non-motorized two-wheelers were analyzed. Injuries incurred in these accidents were demonstrated, divided into type, localization and severity (AIS), and injury-causing parts as well as injury mechanisms described. Due to the different kinematics of non-motorized and motorized two-wheelers, various collision constellations and kinetic forms for both types of traffic participants can be observed in the accident incident.