Automatic thresholding of micro-CT trabecular bone images

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Zhang, Yongping; He, Zhongkun; Fan, Shaojing; He, Kejia; Li, Chen

Automatic thresholding of micro-CT trabecular bone images

Abstract

This paper considers the problem associated with the segmentation of trabecular bone image obtained from micro-computed tomography (microCT). The morphometric indices of a 3D bone image, which are associated with the trabecular bone strength, may play an important clinical role in early predictions of osteoporosis onset and in longitudinal studies of different medical treatments for osteoporosis. Correct estimation of morphologic parameters requires accurate segmentation of bone images. In the present approach, a connectivity-preserving threshold algorithm, connectivity stable thresholding (CST), is introduced. The algorithm is based on the coupling of topological parameter Conn.D and geometric parameter structure model index (SMI) to select an optimal threshold. The experimental results indicate that CST gives good results.
Links

DOI: 10.1109/BMEI.2008.13

WoS: 000257001500005

Cited Works (16)

Year	Entry
1987	Parfitt AM. Trabecular bone architecture in the pathogenesis and prevention of fracture. Am J Med. January 26, 1987;82(suppl 1B):68-72.
1987	Parfitt AM, Drezner MK, Glorieux FH, Kanis JA, Malluche H, Meunier PJ, Ott SM, Recker RR. Bone histomorphometry: standardization of nomenclature, symbols, and units: report of the ASBMR histomorphometry nomenclature committee. J Bone Miner Res. December 1987;2(6):595-610.
1987	Mosekilde L, Mosekilde L, Danielsen CC. Biomechanical competence of vertebral trabecular bone in relation to ash density and age in normal individuals. Bone. 1987;8(2):79-85.
2003	Issever AS, Burghardt A, Patel V, Laib A, Lu Y, Ries M, Majumdar S. A micro-computed tomography study of the trabecular bone structure in the femoral head. J Musculoskel Neuron Interact. 2003;3(2):176-184.
1999	Ding M, Odgaard A, Hvid I. Accuracy of cancellous bone volume fraction measured by micro-CT scanning. J Biomech. 1999;32(3):323-326.
1993	Odgaard A, Gundersen HJG. Quantification of connectivity in cancellous bone, with special emphasis on 3-D reconstructions. Bone. March–April 1993;14(2):173-182.
1966	Arnold JS, Bartley MH, Tont SA, Jenkins DP. Skeletal changes in aging and disease. Clin Orthop Relat Res. December 1966;49:17-38.
1997	Odgaard A. Three-dimensional methods for quantification of cancellous bone architecture. Bone. 1997;20(4):315-328.
1997	Hildebrand T, Rüegsegger P. Quantification of bone microarchitecture with the structure model index. Comput Methods Prog Biomed. 1997;1(1):15-23.
1997	Hildebrand T, Rüegsegger P. A new method for the model-independent assessment of thickness in three-dimensional images. J Microsc (Oxford). 1997;185(1):67-75.
1990	Hodgskinson R, Currey JD. The effect of variation in structure on the Young's modulus of cancellous bone: a comparison of human and non-human material. Proc Inst Mech Eng Part H-J Eng Med. 1990;204(2):115-121.
1985	Kleerekoper M, Villanueva AR, Stanciu J, Rao DS, Parfitt AM. The role of three-dimensional trabecular microstructure in the pathogenesis of vertebral compression fractures. Calcif Tiss Int. 1985;37(6):594-597.
1988	Mosekilde L. Age-related changes in vertebral trabecular bone architecture—assessed by a new method. Bone. 1988;9(4):247-250.
1989	Feldkamp LA, Goldstein SA, Parfitt MA, Jesion G, Kleerekoper M. The direct examination of three‐dimensional bone architecture in vitro by computed tomography. J Bone Miner Res. 1989;4(1):3-11.
2002	Hara T, Tanck E, Homminga J, Huiskes R. The influence of microcomputed tomography threshold variations on the assessment of structural and mechanical trabecular bone properties. Bone. July 2002;31(1):107-109.
1999	Hildebrand T, Laib A, Müller R, Dequeker J, Rüegsegger P. Direct three-dimensional morphometric analysis of human cancellous bone: microstructural data from spine, femur, iliac crest, and calcaneus. J Bone Miner Res. July 1999;14(7):1167-1174.

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Year	Entry
2010	Fredriksson R, Rosén E. Integrated pedestrian countermeasures: potential of head injury reduction combining passive and active countermeasures. In: Proceedings of the 2010 International IRCOBI Conference on the Biomechanics of Impact. September 15-17, 2010; Hannover, Germany.141-153.
2010	Doube M, Kłosowski MM, Arganda-Carreras I, Cordelières FP, Dougherty RP, Jackson JS, Schmid B, Hutchinson JR, Shefelbine SJ. BoneJ: free and extensible bone image analysis in ImageJ. Bone. December 2010;47(6):1076-1079.