Rotational acceleration, brain tissue strain, and the relationship to concussion

Post, Andrew; Hoshizaki, T. Blaine

Affiliations

¹School of Human Kinetics, Faculty of Health Science, University of Ottawa, 200 Lees, Room A106, Ottawa, ON K1S 5S9, Canada

Abstract and keywords

The mechanisms of concussion have been investigated by many researchers using a variety of methods. However, there remains much debate over the relationships between head kinematics from an impact and concussion. This review presents the links between research conducted in different disciplines to better understand the relationship between linear and rotational acceleration and brain strains that have been postulated as the root cause of concussion. These concepts are important when assigning performance variables for helmet development, car design, and protective innovation research.

Keywords: concussion; brain injury; biomechanics; brain strain; finite element modeling

Links

DOI: 10.1115/1.4028983

PubMed: 25363079

WoS: 000350572600001

History

Received: 2014-03-19

Revised: 2014-10-29

Online: 2015-01-29

Cited Works (53)

Year	Entry
1993	Saatman KE. An Isolated Single Myelinated Nerve Fiber Model for the Biomechanics of Axonal Injury [PhD thesis]. Philadelphia, PA: University of Pennsylvania; 1993.
2011	Walsh ES, Rousseau P, Hoshizaki TB. The influence of impact location and angle on the dynamic impact response of a Hybrid III headform. Sports Eng. March 2011;13(3):135-143.
2012	Kendall M, Post A, Rousseau P, Oeur A, Gilchrist MD, Hoshizaki B. A comparison of dynamic impact response and brain deformation metrics within the cerebrum of head impact reconstructions representing three mechanisms of head injury in ice hockey. In: Proceedings of the 2012 International IRCOBI Conference on the Biomechanics of Injury. September 12-14, 2012; Dublin, Ireland.430-440.
2006	Cater HL, Sundstrom LE, Morrison B III. Temporal development of hippocampal cell death is dependent on tissue strain but not strain rate. J Biomech. 2006;39(16):2810-2818.
1974	Ommaya AK, Gennarelli TA. Cerebral concussion and traumatic unconsciousness: correlation of experimental and clinical observations of blunt head injuries. Brain. December 1974;97(4):633-654.
1969	Kopecky JA, Ripperger EA. Closed brain injuries: an engineering analysis. J Biomech. March 1969;2(1):29-34.
1993	Galbraith JA, Thibault LE, Matteson DR. Mechanical and electrical responses of the squid giant axon to simple elongation. J Biomech Eng. February 1993;115(1):13-22.
1944	Gurdjian ES, Lissner HR. Mechanism of head injury as studied by the cathode ray oscilloscope: preliminary report. J Neurosurg. November 1944;1(6):393-399.
1987	Gennarelli TA, Thibault LE, Tomei G, Wiser R, Graham DI, Adams J. Directional dependence of axonal brain injury due to centroidal and non-centroidal acceleration. In: Proceedings of the 31st Stapp Car Crash Conference. November 9-11, 1987; New Orleans, LA. Warrendale, PA: Society of Automotive Engineers:49-53. SAE 872197.
2000	Smith DH, Meaney DF. Axonal damage in traumatic brain injury. Neuroscientist. December 2000;6(6):483-495.
2004	Nicolle S, Lounis M, Willinger R. Shear properties of brain tissue over a frequency range relevant for automotive impact situations: new experimental results. Stapp Car Crash J. 2004;48:239-258. SAE 2004-22-0011.
2007	Kleiven S. Predictors for traumatic brain injuries evaluated through accident reconstructions. Stapp Car Crash J. 2007;51:81-114. SAE 2007-22-0003.
2006	Kleiven S. Evaluation of head injury criteria using a finite element model validated against experiments on localized brain motion, intracerebral acceleration, and intracranial pressure. Int J Crashworthiness. 2006;11(1):65-79.
1994	Bandak FA, Eppinger RH. A three-dimensional finite element analysis of the human brain under combined rotational and translational accelerations. In: Proceedings of the 38th Stapp Car Crash Conference. October 31–November 2, 1994; Fort Lauderdale, FL. Warrendale, PA: Society of Automotive Engineers:145-163. SAE 942215.
2013	Zanetti K, Post A, Karton C, Kendall M, Hoshizaki TB, Gilchrist MD. Identifying injury characteristics for three player positions in American football using physical and finite element modeling reconstructions. In: Proceedings of the 2013 International IRCOBI Conference on the Biomechanics of Injury. September 11-13, 2013; Gothenburg, Sweden.525-535.
2013	Rowson S, Duma SM. Brain injury prediction: assessing the combined probability of concussion using linear and rotational head acceleration. Ann Biomed Eng. May 2013;41(4):873-882.
2011	Meaney DF, Smith DH. Biomechanics of concussion. Clin Sports Med. January 2011;30(1):19-31.
1968	Gurdjian ES, Hodgson VR, Thomas LM, Patrick LM. Significance of relative movements of scalp, skull, and intracranial contents during impact injury of the head. J Neurosurg. July 1968;29(1):70-72.
2012	Daniel RW, Rowson S. Head impact exposure in youth football. Ann Biomed Eng. April 2012;40(4):976-981.
1981	Gennarelli TA, Adams JH, Graham DI. Acceleration induced head-injury in the monkey, I: the model, its biomechanical and physiological correlates. Acta Neuropathol Suppl. 1981;7:23-25.
2003	Willinger R, Baumgartner D. Numerical and physical modelling of the human head under impact: towards new injury criteria. Int J Veh Des. January 2003;32(1-2):94-115.
2004	Hoshizaki TB, Brien SE. The science and design of head protection in sport. Neurosurgery. October 2004;55(4):956-967.
2005	LaPlaca MC, Cullen DK, McLoughlin JJ, Cargill RS II. High rate shear strain of three-dimensional neural cell cultures: a new in vitro traumatic brain injury model. J Biomech. May 2005;38(5):1093-1105.
2007	Elkin BS, Morrison B. Region-specific tolerance criteria for the living brain. Stapp Car Crash J. 2007;51:127-138. SAE 2007-22-0005.
2008	Deck C, Willinger R. Improved head injury criteria based on head FE model. Int J Crashworthiness. December 2008;13(6):667-678.
1943	Holbourn AHS. Mechanics of head injuries. Lancet. October 9, 1943;242(6267):438-441.
2013	Takhounts EG, Craig MJ, Moorhouse K, McFadden J, Hasija V. Development of brain injury criteria (BrIC). Stapp Car Crash J. November 2013;57:243-266.
2003	King AI, Yang KH, Zhang L, Hardy W, Viano DC. Is head injury caused by linear or angular acceleration? In: Proceedings of the 2003 International IRCOBI Conference on the Biomechanics of Impact. September 25, 2003; Lisbon, Portugal.1-12.
2006	Mao H, Zhang L, Yang KH, King AI. Application of a finite element model of the brain to study traumatic brain injury mechanisms in the rat. Stapp Car Crash J. 2006;50:583-600. SAE 2006-22-0022.
1982	Gennarelli TA, Thibault LE, Adams JH, Graham DI, Thompson CJ, Marcincin RP. Diffuse axonal injury and traumatic coma in the primate. Ann Neurol. 1982;12(6):564-574.
1972	Shuck LZ, Advani SH. Rheological response of human brain tissue in shear. J Basic Eng. December 1972;94(4):905-911.
1981	Adams JH, Graham DI, Gennarelli TA. Acceleration induced head injury in the monkey, II: neuropathology. Acta Neuropathol Suppl. 1981;7:26-28.
2013	Post A. The Influence of Dynamic Response Characteristics on Traumatic Brain Injury [PhD thesis]. University of Ottawa; 2013.
2012	Post A, Hoshizaki B, Gilchrist MD. Finite element analysis of the effect of loading curve shape on brain injury predictors. J Biomech. February 23, 2012;45(4):679-683.
1972	Gennarelli TA, Thibault LE, Ommaya AK. Pathophysiologic responses to rotational and translational accelerations of the head. In: Proceedings of the 16th Stapp Car Crash Conference. November 8-10, 1972; Detroit, MI. Warrendale, PA: Society of Automotive Engineers:296-308. SAE 720970.
2000	Bain AC, Meaney DF. Tissue-level thresholds for axonal damage in an experimental model of central nervous system white matter injury. J Biomech Eng. December 2000;122(6):615-622.
2012	Rowson S, Duma SM, Beckwith JG, Chu JJ, Greenwald RM, Crisco JJ, Brolinson PG, Duhaime A-C, McAllister TW, Maerlender AC. Rotational head kinematics in football impacts: an injury risk function for concussion. Ann Biomed Eng. January 2012;40(1):1-13.
2009	Rowson S, Brolinson G, Goforth M, Dietter D, Duma S. Linear and angular head acceleration measurements in collegiate football. J Biomech Eng. June 2009;131(6):061016.
2004	Zhang L, Yang KH, King AI. A proposed injury threshold for mild traumatic brain injury. J Biomech Eng. 2004;126(2):226-236.
2011	Forero Rueda MA, Cuia L, Gilchrist MD. Finite element modelling of equestrian helmet impacts exposes the need to address rotational kinematics in future helmet designs. Comput Methods Biomech Biomed Eng. December 2011;14(12):1021-1031.
2001	Zhang L, Yang KH, Dwarampudi R, Omori K, Li T, Chang K, Hardy WN, Khalil TB, King AI. Recent advances in brain injury research: a new human head model development and validation. Stapp Car Crash J. 2001;45:369-394. SAE 2001-22-0017.
2005	Newman JA, Beusenberg MC, Shewchenko N, Withnall C, Fournier E. Verification of biomechanical methods employed in a comprehensive study of mild traumatic brain injury and the effectiveness of American football helmets. J Biomech. July 2005;38(7):1469-1481.
2000	Prange M, Meaney DF, Margulies SS. Defining brain mechanical properties: effects of region, direction, and species. Stapp Car Crash J. 2000;44:205-213. SAE 2000-01-SC15.
2010	Faul M, Xu L, Wald MM, Coronado VG. Traumatic Brain Injury in the United States: Emergency Department Visits, Hospitalizations and Deaths 2002–2006. Atlanta, GA: Centers for Disease Control and Prevention, National Center for Injury Prevention and Control; March 2010.
1975	Padgaonkar AJ, Krieger KW, King AI. Measurement of angular acceleration of a rigid body using linear accelerometers. J Appl Mech. September 1975;42(3):552-556.
2012	Post A, Oeur A, Hoshizaki B, Gilchrist MD. The influence of centric and non‐centric impacts to American football helmets on the correlation between commonly used metrics in brain injury research. In: Proceedings of the 2012 International IRCOBI Conference on the Biomechanics of Injury. September 12-14, 2012; Dublin, Ireland.419-429.
2003	Morrison B III, Cater HL, Wang CC-B, Thomas FC, Hung CT, Ateshian GA, Sundstrom LE. A tissue level tolerance criterion for living brain developed with an in vitro model of traumatic mechanical loading. Stapp Car Crash J. 2003;47:93-105. SAE 2003-22-0006.
2012	Post A, Hoshizaki TB. Mechanisms of brain impact injuries and their prediction: a review. Trauma. October 2012;14(4):327-349.
2006	Morrison B III, Cater HL, Benham CD, Sundstrom LE. An in vitro model of traumatic brain injury utilising two-dimensional stretch of organotypic hippocampal slice cultures. J Neurosci Meth. 2006;150(2):192-201.
2003	Pellman EJ, Viano DC, Tucker A, Casson IR, Waeckerle JF. Concussion in professional football: reconstruction of game impacts and injuries. Neurosurgery. October 2003;53(4):799-814.
2012	Beckwith JG, Greenwald RM, Chu JJ. Measuring head kinematics in football: correlation between the head impact telemetry system and Hybrid III headform. Ann Biomed Eng. January 2012;40(1):237-248.
1989	Viano DC, King AI, Melvin JW, Weber K. Injury biomechanics research: an essential element in the prevention of trauma. J Biomech. 1989;22(5):403-417.
2013	Jadischke R, Viano DC, Dau N, King AI, McCarthy J. On the accuracy of the Head Impact Telemetry (HIT) System used in football helmets. J Biomech. September 3, 2013;46(13):2310.

Cited By (18)

Year	Entry
2015	Clark JM, Post A, Hoshizaki TB, Gilchrist MD. Determining the relationship between linear and rotational acceleration and MPS for different magnitudes of classified brain injury risk in ice hockey. In: Proceedings of the 2015 International IRCOBI Conference on the Biomechanics of Injury. September 9-11, 2015; Lyon, France.168-179.
2016	Stone BW, Halkon BJ, Harland AR. An explorative study into the mechanics of projectile impacts to the head. In: Proceedings of the 2016 International IRCOBI Conference on the Biomechanics of Injury. September 14-16, 2016; Malaga, Spain.369-380.
2016	Taylor K, Hoshizaki TB, Hoshizaki TB, Gilchrist MD. Dynamic head response and maximum principal tissue strain for helmeted (American football) and non‐helmeted impacts. In: Proceedings of the 2016 International IRCOBI Conference on the Biomechanics of Injury. September 14-16, 2016; Malaga, Spain.217-227.
2024	Karton C, Dehghan P, Azadi A, Fahlstedt M, Hoshizaki TB. An evaluation of the protective performance of a motocross helmet with and without rotational mitigating technology under impacts representing real-world impact surface conditions. In: Proceedings of the 2024 International IRCOBI Conference on the Biomechanics of Injury. September 11-13, 2024; Stockholm, Sweden.1131-1141.
2022	King ARA, Tyedmers A, Gonder S, Yu B, Quenneville CE. Design of a nature-inspired honeycomb bicycle helmet for prevention of traumatic brain injury. In: Proceedings of the 17th Ohio State University Injury Biomechanics Symposium. May 23-24, 2022; Columbus, OH.
2021	Zimmerman KA, Kim J, Karton C, Lochhead L, Sharp DJ, Hoshizaki T, Ghajari M. Player position in American football influences the magnitude of mechanical strains produced in the location of chronic traumatic encephalopathy pathology: a computational modelling study. J Biomech. March 30, 2021;118:110256.
2016	Dawson L. Impact Characteristics Describing Concussive Injury in Youth [Master's thesis]. University of Ottawa; 2016.
2016	Rock BB. A Comparison of Dynamic Response and Brain Tissue Deformation for Ball Carriers and Defensive Tacklers in Professional Rugby Shoulder-to-Head Concussive Impacts [Master's thesis]. University of Ottawa; 2016.
2018	Adanty K. A Comparison Between Two Oblique Test Protocols for Cycling Helmets [Master's thesis]. University of Ottawa; 2018.
2018	Chen W. A Comparison Between Pee Wee and Bantam Youth Ice Hockey Brain Trauma Profiles [Master's thesis]. University of Ottawa; 2018.
2018	Koncan D. Finite Element Modelling of Sport Impacts: Brain Strains from Falls Resulting in Concussion in Young Children and Adults [PhD thesis]. University of Ottawa; 2018.
2018	Taylor K. The Use of Decoupling Structures in Helmet Liners to Reduce Maximum Principal Brain Tissue Strain for Head Impacts [PhD thesis]. University of Ottawa; 2018.
2021	Ferdousi J. Comparison of Frequency and Impact Magnitude of Heading in 1966 and 2018 International Professional Men's Soccer Matches [Master's thesis]. University of Ottawa; 2021.
2022	Krbavac BP. Comparing Brain Trauma Profiles for U15 Ice Hockey Leagues With Standard and Modified Body Contact Rules [Master's thesis]. University of Ottawa; 2022.
2022	Larsen K. Comparison of Brain Strain Magnitudes Calculated Using Head Tracking Impact Parameters and Body Tracking Impact Parameters Obtained from 2D Video [Master's thesis]. University of Ottawa; 2022.
2022	Lowther S. Effect of Rule Changes Occurring Between 2003 and 2016 on Head Impact Frequency and Brain Strain Magnitude in North American Professional Ice Hockey [Master's thesis]. University of Ottawa; 2022.
2022	Murphy A. Comparing Equestrian Helmets With and Without Rotational Technology Using an Equestrian Concussive Specific Helmet Test Protocol [Master's thesis]. University of Ottawa; 2022.
2024	Tenio TV. Material Characterization and Development of Simulant Phantoms for a Biofidelic Head Model [Master's thesis]. York University; September 2024.