Development and reversal of a proteoglycan aggregation defect in normal canine knee cartilage after immobilization

Palmoski, Marshall; Perricone, Elaine; Brandt, Kenneth D.

Affiliations

¹Rheumatology Division, Indiana University School of Medicine, Indianapolis, Indiana 46202

Abstract

Healthy adult dogs were studied for a defect in proteoglycan aggregation by immobilizing one limb for varying periods of time. Immobilization for 6 days resulted in a 41% reduction in proteoglycan synthesis by articular cartilage from the restrained knee compared with the contralateral control knee. After 3 weeks of immobilization, proteoglycan aggregation was no longer demonstrable in cartilage from the constrained limb. The aggregation defect was rapidly reversible and aggregates were again normal size 2 weeks after removal of a cast that had been worn for 6 weeks.

Links

DOI: 10.1002/art.1780220511

PubMed: 444315

WoS: A1979GV95900011

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