Transient solute diffusion in articular cartilage

Torzilli, Peter A.; Adams, Thomas C.; Mis, Raymond J.

Affiliations

¹Cartilage Research Laboratory, Department of Biomechanics, The Hospital for Special Surgery, affiliated with New York Hospital-Cornell Medical College, 535 East 70 Street, New York, NY 10021, U.S.A.

Abstract

The one-dimensional transient diffusion of glucose, inulin and dextran into adult bovine knee articular cartilage was determined for transport times of 1, 5, 15 and 60 min, and 4, 12, 24 and 48 h. The apparent diffusion coefficient and apparent interface partition coefficient were calculated from the concentration-depth profiles within the tissue using a theoretical model for non-steady state solute diffusion. The diffusion coefficient was found to decrease with both solute size and transport time. The partition coefficient also decreased with solute size but increased with transport time. Neither coefficient was dependent on normal tissue fluid or proteoglycan content variations.

Links

DOI: 10.1016/0021-9290(87)90311-3

PubMed: 2437125

WoS: A1987G592300009

History

Received: 1985-06-20

Revised: 1986-05-13

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Cited By (24)

Year	Entry
1990	Torzilli PA, Askari E, Jenkins JT. Water content and solute diffusion properties in articular cartilage. In: Mow VC, Ratcliffe A, Woo SL-Y, eds. Biomechanics of Diarthrodial Joints. Vol 1. New York, NY: Springer-Verlag; 1990:363-390.
2003	Leddy HA, Guilak F. Site-specific molecular diffusion in articular cartilage measured using fluorescence recovery after photobleaching. Ann Biomed Eng. July–August 2003;31(7):753-760.
1997	Torzilli PA, Arduino JM, Gregory JD, Bansal M. Effect of proteoglycan removal on solute mobility in articular cartilage. J Biomech. September 1997;30(9):895-902.
2001	Quinn TM, Morel V, Meister JJ. Static compression of articular cartilage can reduce solute diffusivity and partitioning: implications for the chondrocyte biological response. J Biomech. November 2001;34(11):1463-1469.
2004	Ferguson SJ, Ito K, Nolte L-P. Fluid flow and convective transport of solutes within the intervertebral disc. J Biomech. February 2004;37(2):213-221.
2003	Mauck RL, Hung CT, Ateshian GA. Modeling of neutral solute transport in a dynamically loaded porous permeable gel: implications for articular cartilage biosynthesis and tissue engineering. J Biomech Eng. October 2003;125(5):602-614.
1993	Burstein D, Gray ML, Hartman AL, Gipe R, Foy BD. Diffusion of small solutes in cartilage as measured by nuclear magnetic resonance (nmr) spectroscopy and imaging. J Orthop Res. July 1993;11(4):465-478.
2013	Miller GJ. Mechanoregulation and Mechanotransduction in Skeletal Tissue Differentiation [Master's thesis]. Boston University; 2013.
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2017	Kleinhans KL. Transport Properties in Porcine Meniscus Fibrocartilage [PhD thesis]. University of Miami; August 2017.
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2016	Young WT. Cartilage Stress Relaxation Induced by Intra-Tissue Transport of Cationic Nanoparticles: Implications for Post-Traumatic Osteoarthritis Drug Delivery [Master's thesis]. Cambridge, MA: Massachusetts Institute of Technology; June 2016.
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