Transient solute diffusion in articular cartilage

Torzilli, Peter A.<sup>1</sup>; Adams, Thomas C.<sup>1</sup>; Mis, Raymond J.<sup>1</sup>

Affiliations

¹Cartilage Research Laboratory, Department of Biomechanics, The Hospital for Special Surgery, affiliated with New York Hospital-Cornell Medical College, 535 East 70 Street, New York, NY 10021, U.S.A.

Abstract

The one-dimensional transient diffusion of glucose, inulin and dextran into adult bovine knee articular cartilage was determined for transport times of 1, 5, 15 and 60 min, and 4, 12, 24 and 48 h. The apparent diffusion coefficient and apparent interface partition coefficient were calculated from the concentration-depth profiles within the tissue using a theoretical model for non-steady state solute diffusion. The diffusion coefficient was found to decrease with both solute size and transport time. The partition coefficient also decreased with solute size but increased with transport time. Neither coefficient was dependent on normal tissue fluid or proteoglycan content variations.

Links

DOI: 10.1016/0021-9290(87)90311-3

PubMed: 2437125

WoS: A1987G592300009

History

Received: 1985-06-20

Revised: 1986-05-13

Cited Works (12)

Year	Entry
1970	Maroudas A. Distribution and diffusion of solutes in articular cartilage. Biophys J. May 1970;10(5):365-379.
1977	Maroudas A, Venn M. Chemical composition and swelling of normal and osteoarthrotic femoral head cartilage, II: swelling. Ann Rheum Dis. 1977;36(5):399-406.
1978	Urban JPG, Holm S, Maroudas A. Diffusion of small solutes into the intervertebral disc: as in vivo study. Biorheology. 1978;15(3-4):203-223.
1975	Maroudas A, Stockwell RA, Nachemson A, Urban J. Factors involved in the nutrition of the human lumbar intervertebral disc: cellularity and diffusion of glucose in vitro. J Anat. September 1975;120(1):113-130.
1968	Maroudas A, Bullough P, Swanson SAV, Freeman MAR. The permeability of articular cartilage. J Bone Joint Surg. February 1968;50B(1):166-177.
1979	Maroudas A. Physicochemical properties of articular cartilage. In: Freeman MAR, ed. Adult Articular Cartilage. 2nd ed. Kent, England: Pitman Medical; 1979:215-290.
1977	Urban JPG, Holm S, Maroudas A, Nachemson A. Nutrition of the intervertebral disk: an in vivo study of solute transport. Clin Orthop Relat Res. November 1977;129:101-114.
1984	Mow VC, Holmes MH, Lai WM. Fluid transport and mechanical properties of articular cartilage: a review. J Biomech. 1984;17(5):377-394.
1975	Maroudas A. Biophysical chemistry of cartilaginous tissues with special reference to solute and fluid transport. Biorheology. 1975;12(3-4):233-248.
1976	Maroudas A. Transport of solutes through cartilage: permeability to large molecules. J Anat. November 1976;122(pt 2):335-347.
1976	Torzilli PA, Mow VC. On the fundamental fluid transport mechanisms through normal and pathological articular cartilage during function, I: the formulation. J Biomech. 1976;9(8):541-552.
1980	Mow VC, Kuei SC, Lai WM, Armstrong CG. Biphasic creep and stress relaxation of articular cartilage in compression: theory and experiments. J Biomech Eng. February 1980;102(1):73-84.

Cited By (22)

Year	Entry
2003	Leddy HA, Guilak F. Site-specific molecular diffusion in articular cartilage measured using fluorescence recovery after photobleaching. Ann Biomed Eng. July–August 2003;31(7):753-760.
1997	Torzilli PA, Arduino JM, Gregory JD, Bansal M. Effect of proteoglycan removal on solute mobility in articular cartilage. J Biomech. September 1997;30(9):895-902.
2001	Quinn TM, Morel V, Meister JJ. Static compression of articular cartilage can reduce solute diffusivity and partitioning: implications for the chondrocyte biological response. J Biomech. November 2001;34(11):1463-1469.
2004	Ferguson SJ, Ito K, Nolte L-P. Fluid flow and convective transport of solutes within the intervertebral disc. J Biomech. February 2004;37(2):213-221.
2003	Mauck RL, Hung CT, Ateshian GA. Modeling of neutral solute transport in a dynamically loaded porous permeable gel: implications for articular cartilage biosynthesis and tissue engineering. J Biomech Eng. October 2003;125(5):602-614.
2013	Miller GJ. Mechanoregulation and Mechanotransduction in Skeletal Tissue Differentiation [Master's thesis]. Boston University; 2013.
2012	Shi C. Develop Novel Frap Techniques for Determining Anisotropic Solute Diffusion in Cartilaginous Tissues [PhD thesis]. Clemson, SC: Clemson University; December 2012.
2003	Mauck RL. Functional Tissue Engineering of Articular Cartilage: The Effect of Physical Forces on the in Vitro Growth of Engineered Constructs [PhD thesis]. Columbia University; 2003.
2008	Lima EG. The Tissue-Engineering of Functional Osteochondral Constructs for Cartilage Repair [PhD thesis]. Columbia University; 2008.
2018	DiDomenico CD. Evaluating Macromolecular Transport in Articular Cartilage to Better Understand and Predict Transport of Arthritis Therapeutics [PhD thesis]. Ithaca, NY: Cornell University; August 2018.
2007	Leddy HA. Diffusional Properties of Articular Cartilage [PhD thesis]. Duke University; 2007.
2009	Christensen SE. The Role of Collagen VI in the Structure and Properties of the Knee Joint [PhD thesis]. Duke University; 2009.
2013	Chin HC. Functional Assessment of Articular Cartilage Using Injury-Induced Changes in Solute Transport and Improved Mechanical Characterization [PhD thesis]. McGill University; April 2013.
2013	Moeini M. Solute Transport in Articular Cartilage: Toward Applications of Diffusion, Partitioning and Adsorption for Tissue Functional Assessment [PhD thesis]. McGill University; August 2013.
2004	Yao H. Physical Signals and Solute Transport in Cartilaginous Tissues [PhD thesis]. University of Miami; August 2004.
2010	Jackson AR. Transport and Metabolism of Glucose in Intervertebral Disc [PhD thesis]. University of Miami; December 2010.
2017	Kleinhans KL. Transport Properties in Porcine Meniscus Fibrocartilage [PhD thesis]. University of Miami; August 2017.
1996	García AM. Mechanisms of Macromolecular Transport Through Articular Cartilage: Relevance to Loading [PhD thesis]. Cambridge, MA: Massachusetts Institute of Technology; June 1996.
2016	Young WT. Cartilage Stress Relaxation Induced by Intra-Tissue Transport of Cationic Nanoparticles: Implications for Post-Traumatic Osteoarthritis Drug Delivery [Master's thesis]. Cambridge, MA: Massachusetts Institute of Technology; June 2016.
2007	Buckley CT. On the Development of Scaffolds for Bone Tissue Engineering [PhD thesis]. Trinity College Dublin; September 2007.
2001	DiMicco MA. Collagen Synthesis, Transport, and Deposition in Integrative Articular Cartilage Repair [PhD thesis]. San Diego (UCSD), University of California; 2001.
2002	Li KW. Regulation of Chondrocytes by Static and Dynamic Loading in Articular Cartilage Repair [PhD thesis]. San Diego (UCSD), University of California; 2002.