Factors involved in the nutrition of the human lumbar intervertebral disc:​ cellularity and diffusion of glucose in vitro

Maroudas, A.<sup>1</sup>; Stockwell, R. A.<sup>2</sup>; Nachemson, A.<sup>3</sup>; Urban, J.<sup>1</sup>

Affiliations

¹Biomechanics Unit, Mechanical Engineering Department, Imperial College, London,

²Anatomy Department, University Medical School, Edinburgh

³Sahlgren Orthopaedic Hospital, Gothenburg, Sweden

Links

PubMed: 1184452

PubMedCentral: PMC1231728

WoS: A1975AQ29800008

History

Accepted: 1975-01-1

Cited Works (8)

Year	Entry
1952	Hirsch C, Schajowicz F. Studies on structural changes in the lumbar annulus fibrosus. Acta Orthop Scand. 1952;22(1-4):184-231.
1968	Maroudas A. Physicochemical properties of cartilage in the light of ion exchange theory. Biophys J. May 1968;8(5):575-595.
1970	Maroudas A. Distribution and diffusion of solutes in articular cartilage. Biophys J. May 1970;10(5):365-379.
1945	Coventry MB, Ghormley RK, Kernohan JW. The intervertebral disc: its microscopic anatomy and pathology, I: anatomy, development, and physiology. J Bone Joint Surg. January 1945;27(1):105-112.
1968	Maroudas A, Bullough P, Swanson SAV, Freeman MAR. The permeability of articular cartilage. J Bone Joint Surg. February 1968;50B(1):166-177.
1979	Maroudas A. Physicochemical properties of articular cartilage. In: Freeman MAR, ed. Adult Articular Cartilage. 2nd ed. Kent, England: Pitman Medical; 1979:215-290.
1970	Nachemson A, Lewin T, Maroudas A, Freeman MAR. In vitro diffusion of dye through the end-plates and the annulus fibrosus of human lumbar inter-vertebral discs. Acta Orthop Scand. 1970;41(3):589-607.
1971	Stockwell RA. The interrelationship of cell density and cartilage thickness in mammalian articular cartilage. J Anat. September 1971;109(3):411-421.

Cited By (50)

Year	Entry
1979	Stockwell RA, Meachim G. The chondrocytes. In: Freeman MAR, ed. Adult Articular Cartilage. 2nd ed. Kent, England: Pitman Medical; 1979:69-144.
2000	Wang L, Cowin SC, Weinbaum S, Fritton SP. Modeling tracer transport in an osteon under cyclic loading. Ann Biomed Eng. October 2000;28(10):1200-1209.
2003	Gu WY, Yao H. Effects of hydration and fixed charge density on fluid transport in charged hydrated soft tissues. Ann Biomed Eng. November 2003;31(10):1162-1170.
1981	Lyons G, Eisenstein SM, Sweet MBE. Biochemical changes in intervertebral disc degeneration. Biochim Biophys Acta. 1981;673:443-453.
1978	Urban JPG, Holm S, Maroudas A. Diffusion of small solutes into the intervertebral disc: as in vivo study. Biorheology. 1978;15(3-4):203-223.
1977	Urban JPG, Holm S, Maroudas A, Nachemson A. Nutrition of the intervertebral disk: an in vivo study of solute transport. Clin Orthop Relat Res. November 1977;129:101-114.
1981	Holm S, Maroudas A, Urban JPG, Selstam G, Nachemson A. Nutrition of the intervertebral disc: solute transport and metabolism. Connect Tissue Res. 1981;8(2):101-119.
1987	Torzilli PA, Adams TC, Mis RJ. Transient solute diffusion in articular cartilage. J Biomech. 1987;20(2):203-214.
2004	Ferguson SJ, Ito K, Nolte L-P. Fluid flow and convective transport of solutes within the intervertebral disc. J Biomech. February 2004;37(2):213-221.
1985	Adams MA, Hutton WC. The effect of posture on the lumbar spine. J Bone Joint Surg. August 1985;67B(4):625-629.
1983	Sandover J. Dynamic loading as a possible source of low-back disorders. Spine. September 1983;8(6):652-658.
1991	Stairmand JW, Holm S, Urban JPG. Factors influencing oxygen concentration gradients in the intervertebral disc: a theoretical analysis. Spine. April 1991;16(4):444-449.
1998	Lotz JC, Colliou OK, Chin JR, Duncan NA, Liebenberg E. Compression-induced degeneration of the intervertebral disc: an in vivo mouse model and finite-element study. Spine. December 1, 1998;23(23):2493-2506.
2000	Adams MA, Freeman BJC, Morrison HP, Nelson IW, Dolan P. Mechanical initiation of intervertebral disc degeneration. Spine. July 1, 2000;25(13):1625-1636.
2001	Horner HA, Urban JPG. Effect of nutrient supply on the viability of cells from the nucleus pulposus of the intervertebral disc. Spine. December 1, 2001;26(23):2543-2549.
2012	Kuo J. Bioengineering Approach to Understanding TMJ Pathobiology [PhD thesis]. Clemson, SC: Clemson University; May 2012.
2012	Shi C. Develop Novel Frap Techniques for Determining Anisotropic Solute Diffusion in Cartilaginous Tissues [PhD thesis]. Clemson, SC: Clemson University; December 2012.
2013	Wu Y. Integrating Biomechanics and Cell Physiology to Understanding IVD Nutrition and Cell Homeostasis [PhD thesis]. Clemson, SC: Clemson University; May 2013.
2016	Cisewski SE. Nutrient Related Mechanisms of Intervertebral Disc Degeneration [PhD thesis]. Clemson, SC: Clemson University; August 2016.
2022	Burt KG. Evaluation of Inflammatory Biological Drivers and the Role of the Innate Immune Response During Intervertebral Disc Degeneration [PhD thesis]. Columbia University; 2022.
2021	Lintz M. Tissue Engineering Strategies for Total Disc Replacement: Structure and Mechanical Function of the Intervertebral Disc [PhD thesis]. Ithaca, NY: Cornell University; August 2021.
2002	Wang L. Investigating the Role of Interstitial Fluid Flow in Bone Adaptation and Metabolism [PhD thesis]. New York, NY: The City University of New York; 2002.
2004	Joshi AB. Mechanical Behavior of the Human Lumbar Intervertebral Disc With Polymeric Hydrogel Nucleus Implant: An Experimental and Finite Element Study [PhD thesis]. Drexel University; February 2004.
2020	Ashinsky BG. Multiscale and Multimodal Structure-Function Analysis of Intervertebral Disc Degeneration and Regeneration [PhD thesis]. Drexel University; May 2020.
2007	Boyd LM. Effects of a Genetic Mutation in Type IX Collagen on Morphology and Metabolism in a Murine Model of Intervertebral Disc Degeneration [PhD thesis]. Duke University; 2007.
2013	Francisco AT. Laminin-Functionalized Polyethylene Glycol Hydrogels for Nucleus Pulposus Regeneration [PhD thesis]. Duke University; 2013.
2002	Cheung T-mJ. A Finite Element Study of the Effects of Mechanical Loading on the Fluid Flow and Biomechanical Response of the Intervertebral Disc [Master's thesis]. Hong Kong Polytechnic University; September 2002.
1977	Urban JPG. Fluid and Solute Transport in the Inter-Vertebral Disc [PhD thesis]. Imperial College London; June 1977.
2004	Yao H. Physical Signals and Solute Transport in Cartilaginous Tissues [PhD thesis]. University of Miami; August 2004.
2009	Travascio F. Modeling Molecular Transport and Binding Interactions in Intervertebral Disc [PhD thesis]. University of Miami; December 2009.
2010	Jackson AR. Transport and Metabolism of Glucose in Intervertebral Disc [PhD thesis]. University of Miami; December 2010.
2011	Yuan T-Y. Innovative Methods to Determine Material Properties of Cartilaginous Tissues and Application for Tissue Engineering [PhD thesis]. University of Miami; August 2011.
2016	Zhu Q. Numerical Modeling of Intervertebral Disc Degeneration and Repair [PhD thesis]. University of Miami; May 2016.
2017	Kleinhans KL. Transport Properties in Porcine Meniscus Fibrocartilage [PhD thesis]. University of Miami; August 2017.
2019	Jaworski LM. Nucleus Pulposus of the Intervertebral Disc: The Effect of Environmental Factors on Metabolic Activity [PhD thesis]. University of Miami; December 2019.
2020	Yin X. ATP Metabolism of Intervertebral Disc Cells Under Physiological Nutritional Conditions [PhD thesis]. University of Miami; May 2020.
2018	Long RG. Repair of Herniated Intervertebral Discs: Designing and Translating Annulus Fibrosus Sealants [PhD thesis]. Icahn School of Medicine at Mount Sinai; 2018.
2019	Torre OM. Intervertebral Disc Regeneration in Neonatal Mice [PhD thesis]. Icahn School of Medicine at Mount Sinai; 2019.
2022	Panebianco CJ. Engineering Composite Hydrogels and Discovering Novel Cell Populations for Next-Generation Intervertebral Disc Repair [PhD thesis]. Icahn School of Medicine at Mount Sinai; March 2022.
2008	Mokhbi-Soukane D. Études numériques de la diffusion couplée d'oxygène, glucose et d'acide lactique dans le disque intervertébral [PhD thesis]. École polytechnique de Montréal; June 2008.
2008	Schultz DS. Structure-Function Relationships in Soft Tissue Mechanics: Examining How the Micro-Scale Architecture of Biochemical Constituents Effects Health [PhD thesis]. Berkeley, CA: Berkeley, University of California; 2008.
1998	Colliou OK. Role of Mechanical Loading in Intervertebral Disc Degeneration [PhD thesis]. San Francisco, University of California; 1998.
2007	Ulrich JA. A Repeated Injury Model of Intervertebral Disc Degeneration and the in-Vivo Effects of Thermal Therapy [PhD thesis]. San Francisco, University of California; 2007.
2009	Kim AJ. In Situ Regeneration of the Nucleus Pulposus [PhD thesis]. San Francisco, University of California; 2009.
2010	Rodriguez AG. Human Endplate Permeability and Microstructure and Their Relationship to Disc Degeneration [PhD thesis]. San Francisco, University of California; 2010.
2018	DeLucca JF. Development and Validation of a Finite Element Model of Human Intervertebral Disc in Multiaxial Loading Including the Contributions of Cartilage Endplate and Residual Strains in the Annulus Fibrosus [PhD thesis]. University of Delaware; 2018.
2008	Gorapalli D. Evaluation of a PGLcNAc-Derived Material as an Activator of Intervertebral Disc Tissue Repair [Master's thesis]. University of Toronto; 2008.
2008	Moss IL. Modified-Hyaluronan and Elastin-Like Polypeptide Composite Material for Tissue Engineering of the Nucleus Pulposus [Master's thesis]. University of Toronto; 2008.
2008	Korecki CL. Effects of Compression Loading, Injury, and Age on Intervertebral Disc Mechanics, Biology and Metabolism Using Large Animal Organ and Cell Culture Systems [PhD thesis]. University of Vermont; May 2008.
2021	Barcellona MN. Laminin-Mimetic Peptide-Functionalized Hydrogel Systems for the Phenotypic Modulation of Cells of the Nucleus Pulposus [PhD thesis]. St. Louis, MO: Washington University in St. Louis; January 2021.