The TEM characterization of the lamellar structure of osteoporotic human trabecular bone

Rubin, Matthew Aaron; Jasiuk, Iwona

Affiliations

¹Department of Mechanical and Industrial Engineering, Concordia University, 1455 de Maisonneuve Blvd. West, Montreal, Que., Canada H3G 1M8

Abstract and keywords

The lamellar structure of osteoporotic human trabecular bone was characterized experimentally by means of transmission electron microscopy (TEM). More specifically, the TEM was used to determine if trabecular bone exhibits similar lamellar structural motifs as cortical bone by analyzing unmineralized, mineralized and demineralized bone, and to study the influence of the osteocyte network on the lamellar structure of osteoporotic trabecular bone. Comparison with normal trabecular bone is included. This paper summarizes partial results of a larger study, which addressed the characterization of the hierarchical structure of normal versus osteoporotic human trabecular bone [Rubin, M.A., 2001. Multiscale characterization of the ultrastructure of trabecular bone in osteoporotic and normal humans and in two inbred strains of mice. MS Thesis, Georgia Institute of Technology.] at several structural scales.

Keywords: Trabecular bone; Lamellar level; Osteoporosis; Transmission electron microscopy

Links

DOI: 10.1016/j.micron.2005.07.010

PubMed: 16198582

WoS: 000234068700010

History

Received: 2005-06-14

Revised: 2005-07-25

Accepted: 2005-07-25

Online: 2005-09-2

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2020	Yu B, Pacureanu A, Olivier C, Cloetens P, Peyrin F. Assessment of the human bone lacuno-canalicular network at the nanoscale and impact of spatial resolution. Sci Rep. 2020;10:4567.
2012	Sharma D. Effects of Estrogen Deficiency on the Osteocyte Lacunar-Canalicular Network [PhD thesis]. New York, NY: The City University of New York; 2012.
2010	Feng L. Multi-Scale Characterization of Swine Femoral Cortical Bone and Long Bone Defect Repair by Regeneration [PhD thesis]. University of Illinois at Urbana-Champaign; 2010.
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2007	Akhtar R. Micromechanical Behaviour of Bone [PhD thesis]. University of Manchester; 2007.
2020	Loundagin LL. The Influence of Intracortical Microarchitecture on the Mechanical Fatigue of Bone [PhD thesis]. Calgary, AB: University of Calgary; July 2020.
2014	Reznikov N. The Adaptation of Mechanical Properties of Lamellar Bone Tissue [PhD thesis]. Weizmann Institute of Science; July 2014.
2020	Hamandi FMRA. Hierarchical Structure, Properties and Bone Mechanics At Macro, Micro, and Nano Levels [PhD thesis]. Dayton, OH: Wright State University; 2020.