High-impact exercise stimulated localised adaptation of microarchitecture across distal tibia in postmenopausal women

Du, J.<sup>1,2</sup>; Hartley, C.<sup>3</sup>; Brooke-Wavell, K.<sup>3</sup>; Paggiosi, M. A.<sup>4</sup>; Walsh, J. S.<sup>4</sup>; Li, S.<sup>2</sup>; Silberschmidt, V. V.<sup>2</sup>

Affiliations

¹Academy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin, China

²Wolfson School of Mechanical, Electrical and Manufacturing Engineering, Loughborough University, Leicestershire, UK

³School of Sport, Exercise and Health Science, Loughborough University, Leicestershire, UK

⁴Mellanby Centre for Bone Research, University of Sheffield, Sheffield, UK

Abstract and keywords

Summary: We provided evidence that a 6-month regular hopping exercise intervention can increase trabecular number and possibly trabecular volume fraction of the distal tibia. Our novel localised analysis demonstrated region-specific changes, predominantly in the anterior region, in postmenopausal women.

Introduction: The localisation of bone remodelling and microarchitectural adaptation to exercise loading has not been demonstrated previously in vivo in humans. The aim of this study is to assess the feasibility of using 3D image registration and high-resolution peripheral quantitative computed tomography (HR-pQCT) to investigate the effect of high-impact exercise on human trabecular bone variables and remodelling rate across the distal tibia.

Methods: Ten postmenopausal women were recruited for 6-month unilateral hopping exercises, with HR-pQCT scans taken of both exercise leg (EL) and control leg (CL) for each participant before and after the intervention. A 3D image registration was used to ensure measurements were taken at the same region. Short-term reproducibility tests were conducted prior to the assessment using identical setup. The results were assessed comparing CL and EL, and interaction (time × leg) using a two-way repeated measures analysis of variance (RM-ANOVA).

Results: Across the whole tibia, we observed significant increases in trabecular number (Tb.N) (+ 4.4%) and trabecular bone formation rate (tBFR) (3.3%), and a non-significant increase in trabecular bone volume fraction (BV/TV) (+ 1%) in the EL. Regional resorption was higher in the CL than the EL, with this difference being statistically significant at the lateral tibia. In the EL, tBFR was significantly higher in the anterior region than the medial but a trabecular bone resorption rate (tBRR) showed no significant regional variation. Conversely in the CL, both tBFR and tBRR were significantly higher in the anterior and lateral than the medial region.

Conclusion: We demonstrated that it was possible to detect exercise-related bone adaptation with 3D registration of HR-pQCT scan data. Regular hopping exercise increased Tb.N and possibly BV/TV across the whole distal tibia. A novel finding of the study was that tBFR and tBRR responses to loading were localised: changes were achieved by formation rate exceeding resorption rate in the exercise leg, both globally and at the anterior region where turnover was greatest.

Trial registration: clinicaltrials.gov: NCT03225703

Keywords: 3D image registration; Exercise; Finite element analysis; Formation and resorption rates; HR-pQCT; Trabecular bone

Links

DOI: 10.1007/s00198-020-05714-4

PubMed: 33196852

WoS: 000590060500001

History

Received: 2020-06-19

Accepted: 2020-10-23

Online: 2020-11-16

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2023	Nissen FI, Esser VFC, Bui M, Li S, Hopper JL, Bjørnerem Å, Hansen AK. Is there a causal relationship between physical activity and bone microarchitecture? a study of adult female twin pairs. J Bone Miner Res. July 2023;38(7):951-957.