Sex‐ and site‐specific normative data curves for HR‐pQCT

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Burt, Lauren A.^1,2; Liang, Zhiying^3,4; Sajobi, Tolulope T.^3,4; Hanley, David A.^2,3,5; Boyd, Steven K.^1,2

Sex‐ and site‐specific normative data curves for HR‐pQCT

J Bone Miner Res. 2016;31(11):2041-2047

©2016 American Society for Bone and Mineral Research

Affiliations

¹Department of Radiology, Cumming School of Medicine, University of Calgary, Calgary, Canada

²McCaig Institute for Bone and Joint Health, University of Calgary, Calgary, Canada

³Department of Community Health Sciences, University of Calgary, Calgary, Canada

⁴O’Brien Institute for Public Health, University of Calgary, Calgary, Canada

⁵Department of Oncology, Cumming School of Medicine, University of Calgary, Calgary, Canada
Abstract and keywords

The purpose of this study was to develop age‐, site‐, and sex‐specific centile curves for common high‐resolution peripheral quantitative computed tomography (HR‐pQCT) and finite‐element (FE) parameters for males and females older than 16 years. Participants (n = 866) from the Calgary cohort of the Canadian Multicentre Osteoporosis Study (CaMos) between the ages of 16 and 98 years were included in this study. Participants’ nondominant radius and left tibia were scanned using HR‐pQCT. Standard and automated segmentation methods were performed and FE analysis estimated apparent bone strength. Centile curves were generated for males and females at the tibia and radius using the generalized additive models for location, scale, and shape (GAMLSS) package in R. After GAMLSS analysis, age‐, sex‐, and site‐specific centiles (10th, 25th, 50th, 75th, 90th) for total bone mineral density and trabecular number as well as failure load have been calculated. Clinicians and researchers can use these reference curves as a tool to assess bone health and changes in bone quality.

Keywords: HIGH‐RESOLUTION PERIPHERAL QUANTITATIVE COMPUTED TOMOGRAPHY; LIFE SPAN; NORMAL RANGES; REFERENCE VALUES; PERCENTILES
Links

DOI: 10.1002/jbmr.2873

PubMed: 27192388

WoS: 000388890600017
History

Received: 2016-03-21

Revised: 2016-05-5

Accepted: 2016-05-15

Online: 2016-06-9

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