Bone microarchitecture and estimated strength in 499 adult Danish women and men: a cross-sectional, population-based high-resolution peripheral quantitative computed tomographic study on peak bone structure

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Hansen, Stinus^1,2; Shanbhogue, Vikram^1,2; Folkestad, Lars^1,2; Nielsen, Morten Munk Frost^1,2; Brixen, Kim^1,2

Bone microarchitecture and estimated strength in 499 adult Danish women and men: a cross-sectional, population-based high-resolution peripheral quantitative computed tomographic study on peak bone structure

Calcif Tiss Int. March 2014;94(3):269-281

©2013 Springer Science+Business Media New York

Affiliations

¹Department of Endocrinology, Odense University Hospital, Kløvervænget 6.1.sal, 5000 Odense, Denmark

²Institute of Clinical Research, University of Southern Denmark, Winsløwparken 19, 5000 Odense, Denmark
Abstract and keywords

High-resolution peripheral quantitative computed tomography (HR-pQCT) allows in vivo assessment of cortical and trabecular bone mineral density (BMD), geometry, and microarchitecture at the distal radius and tibia in unprecedented detail. In this cross-sectional study, we provide normative and descriptive HR-pQCT data from a large population-based sample of Danish Caucasian women and men (n = 499) aged 20–80 years. In young adults (<35 years), women (n = 100) compared to men (n = 64) had smaller total and cortical areas, inferior metric trabecular indices, higher network inhomogeneity, lower cortical porosity, and lower finite element estimated bone strength. The changes in parameters with age were estimated from multiple regression analyses. In men, with age the greatest changes (from parameter minimum or maximum) until 80 years were found for cortical porosity (1.91 IQR), BV/TV (−1.09 IQR), and trabecular thickness (−0.87 IQR) in the radius and BV/TV (−1.55 IQR), cortical BMD (−1.25 IQR), and cortical porosity (1.25 IQR) in the tibia. In women changes were most pronounced for cortical porosity (4.76 IQR), trabecular inhomogeneity (3.84 IQR), and cortical BMD (−2.86 IQR) in the radius and cortical BMD (−5.06 IQR), cortical porosity (3.86 IQR), and cortical area (−1.64 IQR) in the tibia. These findings emphasize the age- and sex-related differences in bone morphology, with men having a structural advantage over women from early adult life translating into superior indices of bone strength. With age women are further disadvantaged compared to men by greater decrements in cortical and trabecular architecture in the radius and cortical architecture in the tibia.

Keywords: High-resolution pQCT; Adult; Bone microarchitecture; Bone strength
Links

DOI: 10.1007/s00223-013-9808-5

PubMed: 24146226

WoS: 000332948000002
History

Received: 2013-08-05

Accepted: 2013-10-07

Online: 2013-10-22

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2015	Shanbhogue VV, Hansen S, Frost M, Jørgensen NR, Hermann AP, Henriksen JE, Brixen K. Bone geometry, volumetric density, microarchitecture, and estimated bone strength assessed by HR-pQCT in adult patients with type 1 diabetes mellitus. J Bone Miner Res. December 2015;30(12):2188-2199.
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