Crystal organization in rat bone lamellae

Weiner, Stephen<sup>1</sup>; Arad, Talmon<sup>2</sup>; Traub, Wolfie<sup>2</sup>

Affiliations

¹Department of Isotope Research, The Weizmann Institute of Science, Rehovot 76100, Israel

²Department of Structural Chemistry, The Weizmann Institute of Science, Rehovot 76100, Israel

Abstract and keywords

The plate‐shaped crystals of rat bone are arranged in parallel layers that form coherent structures up to the level of individual lamellae. The crystal layers of the thin lamellae are parallel to the lamellar boundary, whereas those of the thicker lamellae are oblique to the boundary. The basic structure of rat bone can be described as ‘rotated plywood’; a structure hitherto unrecognized in either biologic or synthetic materials.

Keywords: Bone; Collagen; Apctite crystal; Biomineralization

Links

DOI: 10.1016/0014-5793(91)80722-F

PubMed: 2065782

WoS: A1991FW00300012

History

Received: 1991-03-21

Cited Works (7)

Year	Entry
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Cited By (40)

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1998	Weiner S, Wagner HD. The material bone: structure-mechanical function relations. Ann Rev Mater Sci. August 1998;28:271-298.
2002	Benezra Rosen V, Hobbs LW, Spector M. The ultrastructure of anorganic bovine bone and selected synthetic hyroxyapatites used as bone graft substitute materials. Biomaterials. February 2002;23(3):921-928.
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2008	Yoon YJ, Cowin SC. The estimated elastic constants for a single bone osteonal lamella. Biomech Model Mechanobiol. February 2008;7(1):1-11.
2011	Reisinger AG, Pahr DH, Zysset PK. Elastic anisotropy of bone lamellae as a function of fibril orientation pattern. Biomech Model Mechanobiol. February 2011;10(1):67-77.
1995	Turner CH, Chandran A, Pidaparti RMV. The anisotropy of osteonal bone and its ultrastructural implications. Bone. July 1995;17(1):85-89.
1996	Ziv V, Wagner HD, Weiner S. Microstructure-microhardness relations in parallel-fibered and lamellar bone. Bone. May 1996;18(5):417-428.
1997	Weiner S, Arad T, Sabanay I, Traub. W. Rotated plywood structure of primary lamellar bone in the rat: orientations of the collagen fibril arrays. Bone. June 1997;20(6):509-514.
2003	Rubin MA, Jasiuk I, Taylor J, Rubin J, Ganey T, Apkarian RP. TEM analysis of the nanostructure of normal and osteoporotic human trabecular bone. Bone. March 2003;32(3):270-282.
2019	Shah FA, Ruscsák K, Palmquist A. 50 years of scanning electron microscopy of bone: a comprehensive overview of the important discoveries made and insights gained into bone material properties in health, disease, and taphonomy. Bone Res. 2019;7:15.
2015	Stock SR. The mineral–collagen interface in bone. Calcif Tiss Int. September 2015;97(3):262-280.
1994	Ziv V, Weiner S. Bone crystal sizes: a comparison of transmission electron microscopic and x-ray diffraction line width broadening techniques. Connect Tissue Res. 1994;30(3):165-175.
1992	Weiner S, Traub W. Bone structure: from ȧngstroms to microns. FASEB J. February 1992;6(3):879-885.
1992	Wagner HD, Weiner S. On the relationship between the microstructure of bone and its mechanical stiffness. J Biomech. November 1992;25(11):1311-1320.
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1999	Liu D, Weiner S, Wagner HD. Anisotropic mechanical properties of lamellar bone using miniature cantilever bending specimens. J Biomech. July 1999;32(7):647-654.
2006	Donnelly E, Williams RM, Downs SA, Dickinson ME, Baker SP, van der Meulen MCH. Quasistatic and dynamic nanomechanical properties of cancellous bone tissue relate to collagen content and organization. J Mater Res. August 2006;21(8):2106-2117.
1998	Akiva U, Wagner HD, Weiner S. Modelling the three-dimensional elastic constants of parallel-fibred and lamellar bone. J Mater Sci. March 15, 1998;33(6):1497-1509.
2016	Georgiadis M, Müller R, Schneider P. Techniques to assess bone ultrastructure organization: orientation and arrangement of mineralized collagen fibrils. J R Soc Interface. June 1, 2016;13(119):20160088.
1999	Weiner S, Traub W, Wagner HD. Lamellar bone: structure–function relations. J Struct Biol. June 1999;126(3):241-255.
2016	Turunen MJ, Kaspersen JD, Olsson U, Guizar-Sicairos M, Bech M, Schaff F, Tägil M, Jurvelin JS, Isaksson H. Bone mineral crystal size and organization vary across mature rat bone cortex. J Struct Biol. September 2016;195(3):337-344.
2007	Olszta MJ, Cheng X, Jee SS, Kumar R, Kim Y-Y, Kaufman MJ, Douglas EP, Gower LB. Bone structure and formation: a new perspective. Mater Sci Eng R Rep. November 28, 2007;58(3-5):77-116.
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2016	Georgiadis M, Guizar-Sicairos M, Gschwend O, Hangartner P, Bunk O, Müller R, Schneider P. Ultrastructure organization of human trabeculae assessed by 3D sSAXS and relation to bone microarchitecture. PLoS One. August 22, 2016;11(8):e0159838.
2020	Mehraban Alvandi L. Diffuse Damage Repair Mechanism in Bone [PhD thesis]. New York, NY: The City College of New York; 2020.
2005	Yoon YJ. Estimates of Bone Elastic Constants At Sequential Hierarchical Levels [PhD thesis]. New York, NY: The City University of New York; 2005.
2019	Lee BEJ. Characterization Strategies for Bone Ultrastructure and Bone-Cell Interfacing Materials [PhD thesis]. Hamilton, ON: McMaster University; November 2019.
2015	Oftadeh R. Hierarchical Analysis and Multiscale Modelling of Cellular Structures: From Meta Materials to Bone Structure [PhD thesis]. Northeastern University; December 2015.
2010	Deuerling JM. Effects of Ultrastructural Organization on the Mechanical Properties and Anisotropy of Human Cortical Bone [PhD thesis]. University of Notre Dame; December 2010.
2011	Reisinger AG. Modeling and Validation of Multiscale Lamellar Bone Elasticity [PhD thesis]. Vienna University of Technology; November 2011.
2011	Ebacher V. Experimental Study of Deformation and Microcracking in Human Cortical Bone [PhD thesis]. Vancouver, BC: University of British Columbia; May 2011.
1995	Guldberg RE. Mechanical Adaptation of Trabecular Bone Formation in Vivo [PhD thesis]. University of Michigan; 1995.
2016	Arango Villegas C. Study of the Mechanical Behavior of Cortical Bone Microstructure by the Finite Element Method [PhD thesis]. Universität Politècnica de València; May 2016.
2013	Shome C. 3D Orientation Distribution & Deformation of Mineral Crystals in Human Cortical Bone [Master's thesis]. San Antionio, TX: University of Texas at San Antonio; December 2013.
1994	Kohles SS. Elastic and Physiochemical Relationships Within Cortical Bone: Growth Hormone Treatment of a Dwarf Rat Model [PhD thesis]. University of Wisconsin – Madison; 1994.