On the rat model of human osteopenias and osteoporoses

Frost, H. M.<sup>1</sup>; Jee, W. S. S.<sup>2</sup>

Affiliations

¹Department of Orthopaedic Surgery, Southern Colorado Clinic, Pueblo, CO, USA

²Radiobiology Division, University of Utah School of Medicine, Salt Lake City, UT, USA

Abstract and keywords

The idea that rats cannot model human osteopenias errs. The same mechanisms control gains in bone mass (longitudinal bone growth and modeling drifts) and losses (BMU-based remodeling), in young and aged rats and humans. Furthermore, they respond similarly in rats and man to mechanical influences, hormones, drugs and other agents.

Keywords: Rat; Osteoporosis; Osteopenia; Bone modeling; Bone remodeling; Mechanical and nonmechanical agents

Links

DOI: 10.1016/0169-6009(92)90809-R

PubMed: 1392696

WoS: A1992JM39100005

History

Received: 1992-03-09

Accepted: 1992-04-21

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2021	Kushwaha P, Khambadkone SG, Li M, Goodman EJ, Aravindan N, Riddle RC, Tamashiro KLK. Maternal high-fat diet induces long-lasting defects in bone structure in rat offspring through enhanced osteoclastogenesis. Calcif Tiss Int. May 2021;108(5):680-692.
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