Anabolic actions of parathyroid hormone on bone

Dempster, David W.<sup>1,2</sup>; Cosman, Felicia<sup>1,3</sup>; Parisien, May<sup>1,2</sup>; Shen, Victor<sup>1,2</sup>; Lindsay, Robert<sup>1,3</sup>

Affiliations

¹Regional Bone Center, Helen Hayes Hospital, New York State Department of Health, West Haverstraw, New York 10993; and

²Department of Pathology, Columbia University College of Physicians and Surgeons, New York, New York 10032

³Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032

Links

DOI: 10.1210/er.14.6.690

PubMed: 8119233

WoS: A1993MN68300003

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Cited By (32)

Year	Entry
1999	Wronski TJ, Pun S, Liang H. Effects of age, estrogen depletion, and parathyroid hormone treatment on vertebral cancellous wall width in female rats. Bone. October 1999;25(4):465-468.
2020	Kosugi K, Tajima T, Menuki K, Okuma KF, Tokuda K, Fukuda H, Okada Y, Tsukamoto M, Yamanaka Y, Zenke Y, Sakai A. Disruption of the aldehyde dehydrogenase 2 gene increases the bone anabolic response to intermittent PTH treatment in an ovariectomized mouse model. Bone. July 2020;136:115370.
2020	Etani Y, Ebina K, Hirao M, Kitaguchi K, Kashii M, Ishimoto T, Nakano T, Okamura G, Miyama A, Takami K, Goshima A, Kanamoto T, Nakata K, Yoshikawa H. Combined effect of teriparatide and an anti-RANKL monoclonal antibody on bone defect regeneration in mice with glucocorticoid-induced osteoporosis. Bone. October 2020;139:115525.
2021	Siddiqui JA, Le Henaff C, Johnson J, He Z, Rifkin DB, Partridge NC. Osteoblastic monocyte chemoattractant protein-1 (MCP-1) mediation of parathyroid hormone's anabolic actions in bone implicates TGF-β signaling. Bone. February 2021;143:115762.
2005	Felsenberg D, Boonen S. The bone quality framework: determinants of bone strength and their interrelationships, and implications for osteoporosis management. Clin Ther. January 2005;27(1):1-11.
1995	Dobnig H, Turner RT. Evidence that intermittent treatment with parathyroid hormone increases bone formation in adult rats by activation of bone lining cells. Endocrinology. August 1995;136(8):3632-3638.
2005	Bellido T, Ali AA, Gubrij I, Plotkin LI, Fu Q, O’Brien CA, Manolagas SC, Jilka RL. Chronic elevation of parathyroid hormone in mice reduces expression of sclerostin by osteocytes: a novel mechanism for hormonal control of osteoblastogenesis. Endocrinology. November 2005;146(11):4577-4583.
2000	Manolagas SC. Birth and death of bone cells: basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis. Endocr Rev. April 2000;21(2):115-137.
2002	Riggs BL, Khosla S, Melton LJ III. Sex steroids and the construction and conservation of the adult skeleton. Endocr Rev. June 2002;23(3):279-302.
1999	Hirano T, Burr DB, Turner CH, Sato M, Cain RL, Hock JM. Anabolic effects of human biosynthetic parathyroid hormone fragment (1–34), LY333334, on remodeling and mechanical properties of cortical bone in rabbits. J Bone Miner Res. April 1999;14(4):536-545.
2013	Hansen S, Hauge EM, Jensen J-EB, Brixen K. Differing effects of PTH 1–34, PTH 1–84, and zoledronic acid on bone microarchitecture and estimated strength in postmenopausal women with osteoporosis: an 18-month open-labeled observational study using HR-pQCT. J Bone Miner Res. April 2013;28(4):736-745.
2015	Zebaze R, Seeman E. Cortical bone: a challenging geography. J Bone Miner Res. January 2015;30(1):24-29.
1994	Parfitt AM. Osteonal and hemi‐osteonal remodeling: the spatial and temporal framework for signal traffic in adult human bone. J Cell Biochem. July 1994;55(3):273-286.
1999	Jilka RL, Weinstein RS, Bellido T, Roberson P, Parfitt AM, Manolagas SC. Increased bone formation by prevention of osteoblast apoptosis with parathyroid hormone. J Clin Invest. August 1999;104(4):439-446.
1997	Lindsay R, Nieves J, Formica C, Henneman E, Woelfert L, Shen V, Dempster D, Cosman F. Randomised controlled study of effect of parathyroid hormone on vertebral-bone mass and fracture incidence among postmenopausal women on oestrogen with osteoporosis. Lancet. August 23, 1997;350(9077):P550-P555.
2001	Neer RM, Arnaud CD, Zanchetta JR, Prince R, Gaich GA, Reginster J-Y, Hodsman AB, Eriksen EF, Ish-Shalom S, Genant HK, Wang O, Mellström D, Oefjord ES, Marcinowska-Suchowierska E, Salmi J, Mulder H, Halse J, Sawicki AZ, Mitlak BH. Effect of parathyroid hormone (1-34) on fractures and bone mineral density in postmenopausal women with osteoporosis. NEJM. May 10, 2001;344(19):1434-1441.
2007	Canalis E, Giustina A, Bilezikian JP. Mechanisms of anabolic therapies for osteoporosis. NEJM. August 30, 2007;357(9):905-916.
2002	Vahle JL, Sato M, Long GG, Young JK, Francis PC, Engelhardt JA, Westmore MS, Ma YL, Nold JB. Skeletal changes in rats given daily subcutaneous injections of recombinant human parathyroid hormone (1-34) for 2 years and relevance to human safety. Toxicol Pathol. May 1, 2002;30(3):312-321.
1996	Hillam RA. Response of Bone to Mechanical Load and Alterations in Circulating Hormones [PhD thesis]. Bristol, UK: University of Bristol; October 1996.
2020	Ziemian SN. The Roles of Subchondral Bone Mass, Stiffness, and Remodeling in Load-Induced Osteoarthritis Development [PhD thesis]. Ithaca, NY: Cornell University; August 2020.
2019	Bakr M. Parathyroid Hormone Effect on Facilitating Stress Fracture Repair [PhD thesis]. Brisbane, Australia: Griffith University; July 2019.
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2000	Ryder KD. Parathyroid Hormone Modulates the Response of Osteoblast-Like Cells to Mechanical Stimulation [PhD thesis]. Indianapolis, IN: Indiana University; May 2000.
2020	Baskan Erbi̇lgi̇ç Ö. Molecular and Cellular Level Adaptations of Bone Marrow Mesenchymal Progenitor Cells to Chemical and Physical Signals [PhD thesis]. Izmir Institute of Technology; December 2020.
2000	Thompson HGR. Studies on the Purification and Role of IGFBP-5 Protease in Bone [PhD thesis]. Loma Linda University; December 2000.
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1996	Tetradis S. Regulation of the Prostaglandin G/H Synthase Gene by Parathyroid Hormone in Osteoblastic Cells [PhD thesis]. Storrs, CT: University of Connecticut; 1996.
2012	Bassit ACF. Role of IGF-I as a Potential Mediator for the Skeletal Effects of Bone Anabolic Agents [PhD thesis]. University of Florida; August 2012.
2021	Tseng W-J. Structural and Mechanical Responses to Intermittent Parathyroid Hormone Treatment, Discontinuation and Cyclic Administration Regimens [PhD thesis]. Philadelphia, PA: University of Pennsylvania; 2021.
2021	Harrison KD. A Novel in Vivo Synchrotron Radiation Micro-CT Imaging Platform for the Direct Tracking of Remodeling Events in Cortical Bone [PhD thesis]. University of Saskatchewan; December 2021.
2022	Sales EdS. The Spatio-Temporal Behavior of Basic Multicellular Units in a PTH-Induced Cortical Bone Remodeling Rabbit Model [Master's thesis]. University of Saskatchewan; August 2022.