The role of mechanical loading in the onset and progression of osteoarthritis

Griffin, Timothy M.; Guilak, Farshid

Affiliations

¹Departments of Surgery and Biomedical Engineering, Duke University Medical Center, Durham, NC

Abstract and keywords

Osteoarthritis is a progressive joint disease characterized by an imbalance of articular cartilage biosynthesis and degradation attributed to both inflammatory and biomechanical factors. Whereas moderate mechanical loading appears necessary for maintaining healthy cartilage, abnormal joint loading increases the risk of osteoarthritis. Obesity-induced osteoarthritis and the benefits of physical activity may be mediated by systemic levels of proinflammatory mediators as well as local biomechanical factors in the joint.

Keywords: arthritis; obesity; metabolic syndrome X; chondrocyte; exercise; biomechanics; adipokine

Links

DOI: 10.1097/00003677-200510000-00008

PubMed: 16239837

WoS: 000232868900008

History

Accepted: 2005-06-27

Cited Works (1)

Year	Entry
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Cited By (33)

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2011	Guilak F. Biomechanical factors in osteoarthritis. Best Pract Res Clin Rheumatol. December 2011;25(6):815-823.
2006	Andriacchi TP, Mündermann A. The role of ambulatory mechanics in the initiation and progression of knee osteoarthritis. Curr Opin Rhuematol. September 2006;18(5):514-518.
2022	Sritharan P, Schache AG, Culvenor AG, Perraton LG, Bryant AL, Morris HG, Whitehead TS, Crossley KM. Patellofemoral and tibiofemoral joint loading during a single-leg forward hop following ACL reconstruction. J Orthop Res. January 2022;40(1):159-169.
2022	Rapagna S, Roberts BC, Solomon LB, Reynolds KJ, Thewlis D, Perilli E. Relationships between tibial articular cartilage, in vivo external joint moments and static alignment in end-stage knee osteoarthritis: a micro-CT study. J Orthop Res. May 2022;40(5):1125-1134.
2022	Teoli A, Cloutier-Gendron M, Ho SYK, Gu S, Pelletier J-P, Martel-Pelletier J, Robbins SM. The relationship between knee loading during gait and cartilage thickness in nontraumatic and posttraumatic knee osteoarthritis. J Orthop Res. August 2022;40(8):1778-1786.
2022	Saito T, Nakamichi R, Yoshida A, Hiranaka T, Okazaki Y, Nezu S, Matsuhashi M, Shimamura Y, Furumatsu T, Nishida K, Ozaki T. The effect of mechanical stress on enthesis homeostasis in a rat Achilles enthesis organ culture model. J Orthop Res. August 2022;40(8):1872-1882.
2023	Chen F, Sun M, Peng F, Lai Y, Jiang Z, Zhang W, Li T, Jing X. Compressive stress induces spinal vertebral growth plate chondrocytes apoptosis via Piezo1. J Orthop Res. August 2023;41(8):1792-1802.
2017	Silverstein AM. Development of Biofidelic Culture Models of Osteoarthritis [PhD thesis]. Columbia University; 2017.
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2018	Costello KE. Overall Knee Joint Loading Exposure and Clinical Progression of Knee Osteoarthritis [PhD thesis]. Halifax, NS: Dalhousie University; August 2018.
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2023	Zigan CM. Agarose-Collagen Hydrogel Compositions Impact Matrix Mechanics and Extracellular Deposition [Master's thesis]. Purdue University; August 2023.
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2009	Lancianese SL. Modeling the Effect of Obesity and Related Biomechanical Risk Factors on the Onset of Knee Osteoarthritis [PhD thesis]. University of Rochester; 2009.
2020	Lin X. Impact of Macrophages on the Synovial Lymphatic System in Mice With Posttraumatic Osteoarthritis [PhD thesis]. University of Rochester; 2020.
2017	Pamon TJ. The Development and Retention of Articular Cartilage, Disrupted by Metabolic Stressors, is Protected by Low Intensity Vibration [PhD thesis]. Stony Brook, NY: Stony Brook University; May 2017.
2010	Youssef AMRM. The Development of Botulinum Type-a Toxin-Induced Muscle Weakness Model of Osteoarthritis [PhD thesis]. Calgary, AB: University of Calgary; December 2010.
2018	Lorenzen KN. A Comparison of Biomechanical Outcomes in Single Leg Squat and Vertical Drop Jump in Youth and Young Adults With and Without a Previous Youth Sport-Related Knee Joint Injury [Master's thesis]. Calgary, AB: University of Calgary; April 2018.
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2023	Roda GF. Bone and Muscle Changes After Transfemoral Amputation [Master's thesis]. University of Colorado Denver; 2023.
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2022	Ojanen S. Multiscale Imaging and Biomechanics of Articular Cartilage in an Animal Model of Osteoarthritis [PhD thesis]. University of Eastern Finland; 2022.
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2014	Pourmohammadali H. Mechanical and Hydromechanical Stimulation of Chondrocytes for Articular Cartilage Tissue Engineering [PhD thesis]. University of Waterloo; 2014.
2019	Smith CR. Simulating the Effects of Anterior Cruciate Ligament Injury and Treatment on Cartilage Loading During Walking [PhD thesis]. University of Wisconsin – Madison; 2019.
2018	Vignos MF. Longitudinal Investigation of in Vivo Tibiofemoral Kinematics, Cartilage Contact, and Cartilage Composition Prior to and Following Anterior Cruciate Ligament Reconstruction [PhD thesis]. University of Wisconsin – Madison; 2018.
2023	Savadipour A. Mechanosensitive Ion Channels as Therapeutics Targets for Osteoarthritis [PhD thesis]. St. Louis, MO: Washington University in St. Louis; December 2023.