The role of ambulatory mechanics in the initiation and progression of knee osteoarthritis

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Andriacchi, Thomas P.^1,2,3; Mündermann, Annegret^1,3

The role of ambulatory mechanics in the initiation and progression of knee osteoarthritis

Curr Opin Rhuematol. September 2006;18(5):514-518

©2006 Lippincott Williams & Wilkins

Affiliations

¹Department of Mechanical Engineering, Biomechanical Engineering, Stanford University, Stanford, California, USA

²Department of Orthopedics, Stanford University, Stanford, California, USA

³Palo Alto VA, Bone and Joint Center, Palo Alto, California, USA
Abstract and keywords

Purpose of Review: This review examines recent in-vivo studies of ambulation and discusses the fundamental role of mechanics of ambulation in the initiation and progression of osteoarthritis at the knee.

Recent Findings: Recent studies have supported earlier findings that a high adduction moment at the knee during ambulation was most frequently reported to influence the progression of medial compartment osteoarthritis. In contrast to previous findings in patients with osteoarthritis, recent work on healthy subjects reports that cartilage thickness increases with high ambulatory loads. Kinematic changes were associated with the initiation of osteoarthritis. Recent studies of subjects with high risk factors for knee osteoarthritis (obesity and anterior cruciate ligament injury) reported a relationship between kinematic changes during ambulation and the initiation of osteoarthritis at the knee. This review also contrasts the relative influence on osteoarthritis of knee mechanics measured during ambulatory and nonambulatory activities.

Summary: The initiation of osteoarthritis occurs when healthy cartilage experiences some condition (traumatic or chronic) that causes kinematic changes during ambulation at the knee to shift the load-bearing contact location of the joint to a region not conditioned to the new loading. The rate of progression of osteoarthritis is associated with increased load during ambulation.

Keywords: adduction moment; ambulation; biomarkers; gait analysis; knee biomechanics; knee imaging; knee kinematics; knee kinetics; knee osteoarthritis; obesity
Links

DOI: 10.1097/01.bor.0000240365.16842.4e

PubMed: 16896293

WoS: 000240652900014

Cited Works (7)

Year	Entry
2005	Andriacchi TP, Dyrby CO. Interactions between kinematics and loading during walking for the normal and ACL deficient knee. J Biomech. February 2005;38(2):293-298.
1991	Schipplein OD, Andriacchi TP. Interaction between active and passive knee stabilizers during level walking. J Orthop Res. January 1991;9(1):113-119.
2005	Fisher DS. Methods to Systematically Change the Patterns of Gait Associated With Osteoarthritis At the Knee [PhD thesis]. Stanford University; July 2005.
2002	Miyazaki T, Wada M, Kawahara H, Sato M, Baba H, Shimada S. Dynamic load at baseline can predict radiographic disease progression in medial compartment knee osteoarthritis. Ann Rheum Dis. July 2002;61(6):617-622.
2004	Carter DR, Beaupré GS, Wong M, Smith RL, Andriacchi TP, Schurman DJ. The mechanobiology of articular cartilage development and degeneration. Clin Orthop Relat Res. October 2004;427(suppl):S69-S77.
2006	Andriacchi TP, Briant PL, Bevill SL, Koo S. Rotational changes at the knee after ACL injury cause cartilage thinning. Clin Orthop Relat Res. January 2006;442:39-44.
2004	Andriacchi TP, Mündermann A, Smith RL, Alexander EJ, Dyrby CO, Koo S. A framework for the in vivo pathomechanics of osteoarthritis at the knee. Ann Biomed Eng. March 2004;32(3):447-457.

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2009	Rao S, Baumhauer JF, Tome J, Nawoczenski DA. Comparison of in vivo segmental foot motion during walking and step descent in patients with midfoot arthritis and matched asymptomatic control subjects. J Biomech. May 29, 2009;42(8):1054-1060.
2009	Winby CR, Lloyd DG, Besier TF, Kirk TB. Muscle and external load contribution to knee joint contact loads during normal gait. J Biomech. October 16, 2009;42(14):2294-2300.
2023	McCain EM, Dalman MJ, Berno ME, Libera TL, Lewek MD, Sawicki GS, Saul KR. The influence of induced gait asymmetry on joint reaction forces. J Biomech. May 2023;153:111581.
2022	Erhart-Hledik JC, Chu CR, Asay JL, Mahtani GB, Andriacchi TP. Vertical ground reaction force 2 years after anterior cruciate ligament reconstruction predicts 10-year patient-reported outcomes. J Orthop Res. January 2022;40(1):129-137.
2022	Tourville TW, Voigt TB, Choquette RH, Failla MJ, Endres NK, Slauterbeck JR, Beynnon BD, Toth MJ. Skeletal muscle cellular contractile dysfunction after anterior cruciate ligament reconstruction contributes to quadriceps weakness at 6-month follow-up. J Orthop Res. March 2022;40(3):727-737.
2022	Erhart-Hledik JC, Titchenal MR, Migliore E, Asay JL, Andriacchi TP, Chu CR. Cartilage oligomeric matrix protein responses to a mechanical stimulus associate with ambulatory loading in individuals with anterior cruciate ligament reconstruction. J Orthop Res. April 2022;40(4):791-798.
2022	Rapagna S, Roberts BC, Solomon LB, Reynolds KJ, Thewlis D, Perilli E. Relationships between tibial articular cartilage, in vivo external joint moments and static alignment in end-stage knee osteoarthritis: a micro-CT study. J Orthop Res. May 2022;40(5):1125-1134.
2023	Chang AH, Almagor O, Muhammad LN, Guermazi A, Prasad PV, Chmiel JS, Moisio KC, Lee J, Sharma L. Ambulatory support moment contribution patterns and MRI-detected tibiofemoral and patellofemoral disease worsening in adults with knee osteoarthritis: a preliminary study. J Orthop Res. June 2023;41(6):1206-1216.
2023	Bishop EL, McGibbon CA, Kuntze G, Clark ML, Cowper-Smith C, Ronsky JL. Tricompartment offloader knee brace reduces contact forces in adults with multicompartment knee osteoarthritis. J Orthop Res. September 2023;41(9):1925-1933.
2023	Huang C-H, James K, Lanois C, Corrigan P, Yen S-C, Stefanik J. Inter-joint coordination variability is associated with pain severity and joint loading in persons with knee osteoarthritis. J Orthop Res. December 2023;41(12):2610-2616.
2008	Chaudhari AMW, Briant PL, Bevill SL, Koo S, Andriacchi TP. Knee kinematics, cartilage morphology, and osteoarthritis after ACL injury. Med Sci Sports Exer. February 2008;40(2):215-222.
2019	Shegaf A. Cartilage Biomechanical and Mechanobiological Response to Sliding Contact [PhD thesis]. Carleton University; August 2019.
2007	Astephen JL. Biomechanical Factors in the Progression of Knee Osteoarthritis [PhD thesis]. Halifax, NS: Dalhousie University; October 2007.
2011	Conrad J. The Biomechanical Effects of an Externally Applied Orthosis on Medial Compartment Knee Osteoarthritis [Master's thesis]. Halifax, NS: Dalhousie University; December 2011.
2012	Harding GT. Obesity, Moderate Knee Osteoarthritis, and Knee Joint Dynamics [Master's thesis]. Halifax, NS: Dalhousie University; July 2012.
2014	Amiri P. Obesity and Its Influence on Knee Joint Contact Forces in Individuals With Moderate Knee Osteoarthritis [Master's thesis]. Halifax, NS: Dalhousie University; August 2014.
2019	Englander ZA. 3D Dynamic in Vivo Imaging of Joint Motion: Application to Measurement of Anterior Cruciate Ligament Function [PhD thesis]. Duke University; 2019.
2021	McCain EM. Understanding the Neuromechanics and Energetics of Clinical Gait Using Joint Restrictions to Impose Asymmetric Stepping [PhD thesis]. North Carolina State University; 2021.
2014	Lathrop RL. Investigation of Measurable Biomechanical Factors That May Influence Articular Cartilage Degeneration in the Knee [PhD thesis]. The Ohio State University; 2014.
2015	Freisinger GM. Varus-Valgus Knee Laxity and Biomechanical Function in Patients With Severe Osteoarthritis and After Total Knee Arthroplasty [PhD thesis]. The Ohio State University; 2015.
2012	Chan DD. Displacements Under Applied Loading With MRI for the Estimation of High-Precision Strains in Soft Tissues [PhD thesis]. Purdue University; 2012.
2016	Hassan EA. Multivariate Techniques in Biomechanical Analysis [PhD thesis]. Queen's University; August 2016.
2018	Clouthier AL. The Relationship Between Knee Joint Shape and Function: Implications for Pathology and Treatment [PhD thesis]. Queen's University; September 2018.
2019	Saliba CM. Two Muscles Are Better Than One: Co-Contraction Engages Antagonistic Muscles in Response to Perturbation [PhD thesis]. Queen's University; July 2019.
2011	Responte DJ. Novel Exogenous Agents for Improving Articular Cartilage Tissue Engineering [PhD thesis]. Houston, TX: Rice University; October 2011.
2009	Lancianese SL. Modeling the Effect of Obesity and Related Biomechanical Risk Factors on the Onset of Knee Osteoarthritis [PhD thesis]. University of Rochester; 2009.
2010	Netravali NA. Meniscal Damage, Partial Medial Meniscectomy, and the Development of Osteoarthritis [PhD thesis]. Stanford University; November 2010.
2010	Scanlan SF. Understanding the Interaction Between Graft Placement, Gait Mechanics, and Cartilage Morphology as a Pathway to Osteoarthristis in the ACL Reconstructed Knee [PhD thesis]. Stanford University; December 2010.
2013	Zabala M. The Effects of ACL Injury on Gait Mechanics and the Initiation of Osteoarthritis [PhD thesis]. Stanford University; June 2013.
2016	Chehab EF. Understanding the Pathogenesis of Age-Related Knee Osteoarthritis [PhD thesis]. Stanford University; November 2016.
2016	Edd SN. The Development of Post-Traumatic and Idiopathic Osteoarthritis of the Knee [PhD thesis]. Stanford University; May 2016.
2019	Wayne CA. The Effect of Body Mass Index on the Biomechanics Before and After Total Knee Arthroplasty [Master's thesis]. Edmonton, AB: University of Alberta; 2019.
2015	Lee JK. Bioactive and Mechanical Stimuli for Engineering Neocartilage With Native Tissue-Like Tensile Properties [PhD thesis]. Davis, University of California; 2015.
2014	Hansen BC. Distal Femur Articular Cartilage Surface Topology: Health, Acute Injury, and Repair [PhD thesis]. San Diego (UCSD), University of California; 2014.
2014	Li L. Computational Simulation of Knee Osteoarthritis Development [PhD thesis]. University of Florida; December 2014.
2017	Lakes EH. Advancing Methods for Multiscale Mechanics in Orthopaedic Research [PhD thesis]. University of Florida; December 2017.
2013	Deneweth JM. Mapping the Biomechanical Properties of Human Knee Cartilage [PhD thesis]. University of Michigan; 2013.
2011	Trutiak N. Regional Biomechanical Properties of the Articular Surface, in the Human Distal Femur, in Health and Disease [Master's thesis]. University of Guelph; May 2011.
2019	Kingston DC. Development of a Full Flexion 3D Musculoskeletal Model of the Knee Considering Intersegmental Contact and Deep Muscle Activity During High Knee Flexion [PhD thesis]. University of Waterloo; 2019.
2019	Renner KE. Assessing Limb Symmetry Using the Clinically Accessible Loadsol® [PhD thesis]. Virginia Polytechnic Institute and State University; March 13, 2019.
2014	Leitch KM. Biomechanical Investigations of Medial Opening Wedge High Tibial Osteotomy: Gait Analysis, Materials Testing and Dynamic Radiography [PhD thesis]. University of Western Ontario; 2014.
2014	Choi KW. Computational Approaches for Segmenting Cartilage Morphology and Simulating Knee Joint Contact Pressure During Human Walking [PhD thesis]. University of Wisconsin – Madison; 2014.
2015	Kaiser J. Assessment of Cartilage Contact and Early Degeneration Following ACL Reconstruction [PhD thesis]. University of Wisconsin – Madison; 2015.
2023	Knurr KA. Recovery of Running Biomechanics After Anterior Cruciate Ligament Reconstruction [PhD thesis]. University of Wisconsin – Madison; 2023.