Optimizing Running Style to Restore Knee Contact Location Post ACL Rupture

While recreational running is popular, changes in tibiofemoral contact location after ACL injury can lead to early-onset knee osteoarthritis. Current treatments of bracing and reconstructive surgery do not fully restore tibiofemoral contact to pre-injury locations and, therefore, do not prevent early-onset osteoarthritis. This thesis investigated whether contact could shift back towards healthy, pre-injury locations by modifying a runner’s kinematics. One hundred running styles, with corresponding ground reaction forces, were synthesized using a Principal Component Analysis (PCA)-based regression model constructed from an existing running dataset. Tibiofemoral contact mechanics were estimated using the Concurrent Optimization of Muscle Activations and Kinematics (COMAK) approach with an ACL-deficient musculoskeletal model. Compared with baseline case with unaltered pre-injury kinematics after ACL rupture, several of the synthesized trials reduced deviation on contact relative to a healthy, preinjury simulation. This study shows that in-vivo investigation should be done to study the effects of kinematics modifications on TF contact.

Year	Entry
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Year

Entry

2007

Delp SL, Anderson FC, Arnold AS, Loan P, Habib A, John CT, Guendelman E, Thelen DG. OpenSim: open-source software to create and analyze dynamic simulations of movement. IEEE Trans Biomed Eng. November 2007;54(11):1940-1950.

2001

Elder SH, Goldstein SA, Kimura JH, Soslowsky LJ, Spengler DM. Chondrocyte differentiation is modulated by frequency and duration of cyclic compressive loading. Ann Biomed Eng. June 2001;29(6):476-482.

2001

Anderson FC, Pandy MG. Dynamic optimization of human walking. J Biomech Eng. October 2001;123(5):381-390.

2008

Chaudhari AMW, Briant PL, Bevill SL, Koo S, Andriacchi TP. Knee kinematics, cartilage morphology, and osteoarthritis after ACL injury. Med Sci Sports Exer. February 2008;40(2):215-222.

1999

Li G, Gil J, Kanamori A, Woo SL-Y. A validated three-dimensional computational model of a human knee joint. J Biomech Eng. December 1999;121(6):657-662.