Optimizing Running Style to Restore Knee Contact Location Post ACL Rupture

While recreational running is popular, changes in tibiofemoral contact location after ACL injury can lead to early-onset knee osteoarthritis. Current treatments of bracing and reconstructive surgery do not fully restore tibiofemoral contact to pre-injury locations and, therefore, do not prevent early-onset osteoarthritis. This thesis investigated whether contact could shift back towards healthy, pre-injury locations by modifying a runner’s kinematics. One hundred running styles, with corresponding ground reaction forces, were synthesized using a Principal Component Analysis (PCA)-based regression model constructed from an existing running dataset. Tibiofemoral contact mechanics were estimated using the Concurrent Optimization of Muscle Activations and Kinematics (COMAK) approach with an ACL-deficient musculoskeletal model. Compared with baseline case with unaltered pre-injury kinematics after ACL rupture, several of the synthesized trials reduced deviation on contact relative to a healthy, preinjury simulation. This study shows that in-vivo investigation should be done to study the effects of kinematics modifications on TF contact.

Year	Entry
2007	Delp SL, Anderson FC, Arnold AS, Loan P, Habib A, John CT, Guendelman E, Thelen DG. OpenSim: open-source software to create and analyze dynamic simulations of movement. IEEE Trans Biomed Eng. November 2007;54(11):1940-1950.
2001	Elder SH, Goldstein SA, Kimura JH, Soslowsky LJ, Spengler DM. Chondrocyte differentiation is modulated by frequency and duration of cyclic compressive loading. Ann Biomed Eng. June 2001;29(6):476-482.
2005	Griffin TM, Guilak F. The role of mechanical loading in the onset and progression of osteoarthritis. Exerc Sport Sci Rev. October 2005;33(4):195-200.
2008	Chaudhari AMW, Briant PL, Bevill SL, Koo S, Andriacchi TP. Knee kinematics, cartilage morphology, and osteoarthritis after ACL injury. Med Sci Sports Exer. February 2008;40(2):215-222.
2002	Haut Donahue TL, Hull ML, Rashid MM, Jacobs CR. A finite element model of the human knee joint for the study of tibio-femoral contact. J Biomech Eng. June 2002;124(3):273-280.
1991	Clark JM. Variation of collagen fiber alignment in a joint surface: a scanning electron microscope study of the tibial plateau in dog, rabbit, and man. J Orthop Res. March 1991;9(2):246-257.
1981	Crowninshield RD, Brand RA. A physiologically based criterion of muscle force prediction in locomotion. J Biomech. 1981;14(11):793-801.
2007	Lohmander LS, Englund PM, Dahl LL, Roos EM. The long-term consequence of anterior cruciate ligament and meniscus injuries: osteoarthritis. Am J Sports Med. October 2007;35(10):1756-1769.
2005	Leardini A, Chiari L, Della Croce U, Cappozzo A. Human movement analysis using stereophotogrammetry, III: soft tissue artifact assessment and compensation. Gait Post. February 2005;21(2):212-225.
2001	Anderson FC, Pandy MG. Dynamic optimization of human walking. J Biomech Eng. October 2001;123(5):381-390.
2015	Hicks JL, Uchida TK, Seth A, Rajagopal A, Delp SL. Is my model good enough? best practices for verification and validation of musculoskeletal models and simulations of movement. J Biomech Eng. February 2015;137(2):020905.
2004	Andriacchi TP, Mündermann A, Smith RL, Alexander EJ, Dyrby CO, Koo S. A framework for the in vivo pathomechanics of osteoarthritis at the knee. Ann Biomed Eng. March 2004;32(3):447-457.
2006	Benoit DL, Ramsey DK, Lamontagne M, Xu L, Wretenberg P, Renström P. Effect of skin movement artifact on knee kinematics during gait and cutting motions measured in vivo. Gait Post. October 2006;24(2):152-164.
1976	Markolf KL, Mensch JS, Amstutz HC. Stiffness and laxity of the knee: the contributions of the supporting structures: a quantitative in vitro study. J Bone Joint Surg. July 1976;58A(5):583-594.
2014	Fluit R, Andersen MS, Kolk S, Verdonschot N, Koopman HFJM. Prediction of ground reaction forces and moments during various activities of daily living. J Biomech. July 18, 2014;47(10):2321-2329.
1997	Reinschmidt C, van den Bogert A, Nigg B, Lundberg A, Murphy N. Effect of skin movement on the analysis of skeletal knee joint motion during running. J Biomech. July 1997;30(7):729-732.
1999	Li G, Gil J, Kanamori A, Woo SL-Y. A validated three-dimensional computational model of a human knee joint. J Biomech Eng. December 1999;121(6):657-662.

Year

Entry

2007

Delp SL, Anderson FC, Arnold AS, Loan P, Habib A, John CT, Guendelman E, Thelen DG. OpenSim: open-source software to create and analyze dynamic simulations of movement. IEEE Trans Biomed Eng. November 2007;54(11):1940-1950.

2001

Elder SH, Goldstein SA, Kimura JH, Soslowsky LJ, Spengler DM. Chondrocyte differentiation is modulated by frequency and duration of cyclic compressive loading. Ann Biomed Eng. June 2001;29(6):476-482.

2005

Griffin TM, Guilak F. The role of mechanical loading in the onset and progression of osteoarthritis. Exerc Sport Sci Rev. October 2005;33(4):195-200.

2008

Chaudhari AMW, Briant PL, Bevill SL, Koo S, Andriacchi TP. Knee kinematics, cartilage morphology, and osteoarthritis after ACL injury. Med Sci Sports Exer. February 2008;40(2):215-222.

2002

Haut Donahue TL, Hull ML, Rashid MM, Jacobs CR. A finite element model of the human knee joint for the study of tibio-femoral contact. J Biomech Eng. June 2002;124(3):273-280.