The problem of joint contact mechanics in articular cartilage can be studied theoretically with an exact solution only for small displacements and 2-D or axi symmetric geometries (Wu et al., 1997). When studying a real joint geometry, implementation of sophisticated numerical methods such as finite element (F.E.) analysis is necessary to represent the complexity of such problem. In this study, I implemented the biphasic model proposed by Holmes and Mow (1990) into the commercially available F.E. software ABAQUS 6.3, to simulate the Three Dimensional (3-D) patella and femoral groove contact problem. The main purpose of this study has been to apply a theoretical model of articular cartilage to the joint contact problem and to investigate the relationship between joint alignment and cartilage contact stress in a real 3-D model of the patellofemoral joint.