Periosteal bone formation:​ a neglected determinant of bone strength

Seeman, Ego

Affiliations

¹Austin Hospital, University of Melbourne, Melbourne, Australia

Links

DOI: 10.1056/NEJMp038101

PubMed: 12878736

WoS: 000184312800002

Cited Works (3)

Year	Entry
2002	Currey JD. Bones: Structure and Mechanics. Princeton, NJ: Princeton University Press; 2002.
1992	Balena R, Shih M-S, Parfitt AM. Bone resorption and formation on the periosteal envelope of the ilium: a histomorphometric study in healthy women. J Bone Miner Res. December 1992;7(12):1475-1482.
2001	Duan Y, Turner CH, Kim B-T, Seeman E. Sexual dimorphism in vertebral fragility is more the result of gender differences in age-related bone gain than bone loss. J Bone Miner Res. December 2001;16(12):2267-2275.

Cited By (34)

Year	Entry
2025	Goldman HM, Robbins Schug G. Pediatric bone histomorphology and environmental stresses. In: Stout SD, Crowder C, eds. Bone Histology: A Biological Anthropological Perspective. 2nd ed. Boca Raton, FL: CRC Press; 2025:90-125.
2020	Su Y, Wang L, Liu X, Yang M, Yi C, Liu Y, Huang P, Guo Z, Yu A, Cheng X, Wu X, Blake GM, Engelke K. Lack of periosteal apposition in the head and neck of femur after menopause in Chinese women with high risk for hip fractures: a cross-sectional study with QCT. Bone. October 2020;139:115545.
2021	Wang L, Hou S, Sabsovich I, Guo T-Z, Wei T, Kingery WS. Mice lacking substance P have normal bone modeling but diminished bone formation, increased resorption, and accelerated osteopenia with aging. Bone. March 2021;144:115806.
2021	Whitney DG, Hurvitz EA, Caird MS. Critical periods of bone health across the lifespan for individuals with cerebral palsy: informing clinical guidelines for fracture prevention and monitoring. Bone. September 2021;150:116009.
2022	O'Leary TJ, Izard RM, Tang JCY, Fraser WD, Greeves JP. Sex differences in tibial adaptations to arduous training: an observational cohort study. Bone. July 2022;160:116426.
2022	Bolger MW, Romanowicz GE, Bigelow EMR, Ward FS, Ciarelli A, Jepsen KJ, Kohn DH. Divergent mechanical properties of older human male femora reveal unique combinations of morphological and compositional traits contributing to low strength. Bone. October 2022;163:116481.
2008	Seeman E. Bone quality: the material and structural basis of bone strength. J Bone Min Metab. 2008;26(1):1-8.
2005	Nieves JW, Formica C, Ruffing J, Zion M, Garrett P, Lindsay R, Cosman F. Males have larger skeletal size and bone mass than females, despite comparable body size. J Bone Miner Res. March 2005;20(3):529-535.
2006	Szulc P, Seeman E, Duboeuf F, Sornay-Rendu E, Delmas PD. Bone fragility: failure of periosteal apposition to compensate for increased endocortical resorption in postmenopausal women. J Bone Miner Res. December 2006;21(12):1856-1863.
2019	Zimmermann EA, Riedel C, Schmidt FN, Stockhausen KE, Chushkin Y, Schaible E, Gludovatz B, Vettorazzi E, Zontone F, Püschel K, Amling M, Ritchie RO, Busse B. Mechanical competence and bone quality develop during skeletal growth. J Bone Miner Res. August 2019;34(8):1461-1472.
2020	Hart NH, Newton RU, Tan2 J, Rantalainen T, Chivers P, Siafarikas A, Nimphius S. Biological basis of bone strength: anatomy, physiology and measurement. J Musculoskel Neuron Interact. September 2020;20(3):347-371.
2006	Seeman E, Delmas PD. Bone quality: the material and structural basis of bone strength and fragility. NEJM. May 25, 2006;354(21):2250-2261.
2014	Fonseca H, Moreira-Gonçalves D, Coriolano H-JA, Duarte JA. Bone quality: the determinants of bone strength and fragility. Sports Med. January 2014;44(1):37-53.
2011	Burt LA. Upper Body Bone Strength and Muscle Function in Non-Elite Artistic Gymnasts [PhD thesis]. Australian Catholic University; May 2011.
2017	Billington E. Emerging Issues in Osteoporosis [MD thesis]. Auckland, New Zealand: University of Auckland; 2017.
2019	Ó Breasail M. The Quantification of Pregnancy-Induced Bone Mineral Mobilisation in the Maternal Appendicular Skeleton With Novel Peripheral Quantitative Computed Tomography (pQCT) Techniques [PhD thesis]. Cambridge, UK: University of Cambridge; 2019.
2004	Rivadeneira Ramírez F. Osteoporosis: From Genes to Phenotypes [PhD thesis]. Erasmus University Rotterdam; 2004.
2015	Weatherholt AM. Translational Studies Into the Effects of Exercise on Estimated Bone Strength [PhD thesis]. Indianapolis, IN: Indiana University; September 2015.
2013	Gaddini GW. Effects of 12 Months of Voluntary Alcohol Self-Administration on Intracortical Bone Remodeling in a Rhesus Macaque Model [Master's thesis]. Oregon State University; 2013.
2019	Jammy GR. Skeletal and Muscle Health Among Rural South Indian Older Population [PhD thesis]. University of Pittsburgh; 2019.
2018	Samvelyan H. The Effect of Timing of Feeding on Bone's Adaptive Response to Mechanical Loading [PhD thesis]. University of Sheffield; March 2018.
2005	Ashe MC. Upper Limb Bone Health: Cadaveric, Imaging and Clinical Studies With Special Emphasis on Peripheral Quantitative Computed Tomography [PhD thesis]. Vancouver, BC: University of British Columbia; April 2005.
2005	Manske SL. Magnetic Resonance Imaging as an Instrument to Assess the Association Between Femoral Neck Bone Geometry and Strength of the Proximal Femur [Master's thesis]. Vancouver, BC: University of British Columbia; October 2005.
2006	Macdonald HM. Effectiveness of a School-Based Physical Activity Intervention for Increasing Bone Strength in Children: Action Schools! British Columbia [PhD thesis]. Vancouver, BC: University of British Columbia; July 2006.
2015	Tan VPS. Effects of a School-Based Physical Activity Intervention on Adolescent Bone Strength, Structure and Density: The Health Promoting Secondary Schools (HPSS) Bone Health Study [PhD thesis]. Vancouver, BC: University of British Columbia; June 2015.
2017	Gabel LEC. Bone Strength Accrual Across Adolescent Growth and the Influences of Physical Activity and Sedentary Time [PhD thesis]. Vancouver, BC: University of British Columbia; April 2017.
2012	Nishiyama KKS. In Vivo Assessment of Bone Microarchitecture and Estimated Bone Strength [PhD thesis]. Calgary, AB: University of Calgary; October 2012.
2010	Melhus G. Molecular Studies on Bone With Focus on Fracture Healing in Experimental Osteoporosis [PhD thesis]. Oslo, Norway: University of Oslo; 2010.
2023	Tits A. Attaching Soft to Hard: A Multimodal Correlative Investigation of the Tendon-Bone Interface [PhD thesis]. Liège, Belgique: Université de Liège; 2023.
2015	Begun DL. Age-Related Changes in Bone: Variation and Factors Influencing Bone Fragility [PhD thesis]. University of Michigan; 2015.
2016	Vrahna C. Investigating the Effects of Downstream Parathyroid Hormone (PTH) Targets on Bone Strength and Quality [PhD thesis]. Melbourne, Australia: The University of Melbourne; December 2016.
2020	Sharma AK. Evaluation of Renal Bone Disease: Advancing Our Understanding of Associations and Diagnostic Challenges [PhD thesis]. University of Melbourne; April 2020.
2013	Eleazer CD. The Interaction of Mechanical Loading and Metabolic Stress on Human Cortical Bone: Testing Anthropological Assumptions Using Cross-Sectional Geometry and Histomorphology [PhD thesis]. Knoxville, University of Tennessee; August 2013.
2011	Lala D. Determinants of Fracture Risk Among Individuals With Spinal Cord Injury: A Case Control Study [Master's thesis]. University of Waterloo; 2011.