Mechanisms of anabolic therapies for osteoporosis

Canalis, Ernesto<sup>1,2</sup>; Giustina, Andrea<sup>3</sup>; Bilezikian, John P.<sup>4</sup>

Affiliations

¹Department of Research, Saint Francis Hospital and Medical Center, Hartford, CT

²University of Connecticut School of Medicine, Farmington

³Department of Internal Medicine, University of Brescia, Brescia, Italy

⁴Department of Medicine, College of Physicians and Surgeons, Columbia University, New York

Links

DOI: 10.1056/NEJMra067395

PubMed: 17761594

WoS: 000249065700009

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Cited By (31)

Year	Entry
2008	Sugiyama T, Saxon LK, Zaman G, Moustafa A, Sunters A, Price JS, Lanyon LE. Mechanical loading enhances the anabolic effects of intermittent parathyroid hormone (1–34) on trabecular and cortical bone in mice. Bone. August 2008;43(2):238-248.
2020	Ma Y, Wu X, Xiao X, Ma Y, Feng L, Yan W, Chen J, Yang D. Effects of teriparatide versus percutaneous vertebroplasty on pain relief, quality of life and cost-effectiveness in postmenopausal females with acute osteoporotic vertebral compression fracture: a prospective cohort study. Bone. February 2020;131:115154.
2021	Grillari J, Mäkitie RE, Kocijan R, Haschka J, Vázquez DC, Semmelrock E, Hackl M. Circulating miRNAs in bone health and disease. Bone. April 2021;145:115787.
2015	Oftadeh R, Perez-Viloria M, Villa-Camacho JC, Vaziri A, Nazarian A. Biomechanics and mechanobiology of trabecular bone: a review. J Biomech Eng. January 2015;137(1):010802.
2020	Henaff CL, Ricarte F, Finnie B, He Z, Johnson J, Warshaw J, Kolupaeva V, Partridge NC. Abaloparatide at the same dose has the same effects on bone as PTH (1‐34) in mice. J Bone Miner Res. April 2020;35(4):714-724.
2020	Zhou Y, Yang Y, Jing Y, Yuan T, Sun L, Tao B, Liu J, Zhao H. BMP9 reduces bone loss in ovariectomized mice by dual regulation of bone remodeling. J Bone Miner Res. May 2020;35(5):978-993.
2021	Ramchand SK, David NL, Lee H, Bruce M, Bouxsein ML, Leder BZ, Tsai JN. Effects of combination denosumab and high‐dose teriparatide administration on bone microarchitecture and estimated strength: the DATA‐HD HR‐pQCT study. J Bone Miner Res. January 2021;36(1):41-51.
2021	Dempster DW, Zhou H, Rao SD, Recknor C, Miller PD, Leder BZ, Annett M, Ominsky MS, Mitlak BH. Early effects of abaloparatide on bone formation and resorption indices in postmenopausal women with osteoporosis. J Bone Miner Res. April 2021;36(4):644-653.
2021	Weigl M, Kocijan R, Ferguson J, Leinfellner G, Heimel P, Feichtinger X, Pietschmann P, Grillari J, Zwerina J, Redl H, Hackl M. Longitudinal changes of circulating miRNAs during bisphosphonate and teriparatide treatment in an animal model of postmenopausal osteoporosis. J Bone Miner Res. June 2021;36(6):1131-1144.
2022	Wang W, Azar T, Tseng W-J, Pei S, Zhou Y, Jiang X, Dyment N, Liu XS. Distinct responses of modeling- and remodeling-based bone formation to the discontinuation of intermittent parathyroid hormone treatment in ovariectomized rats. J Bone Miner Res. November 2022;37(11):2215-2225.
2011	Rachner TD, Khosla S, Hofbauer LC. Osteoporosis: now and the future. Lancet. April 9, 2011;377(9773):1276-1287.
2018	Kendler DL, Marin F, Zerbini CAF, Russo LA, Greenspan SL, Zikan V, Bagur A, Malouf-Sierra J, Lakatos P, Fahrleitner-Pammer A, Lespessailles E, Minisola S, Body JJ, Geusens P, Möricke R, López-Romero P. Effects of teriparatide and risedronate on new fractures in post-menopausal women with severe osteoporosis (VERO): a multicentre, double-blind, double-dummy, randomised controlled trial. Lancet. January 20, 2018;391(10117):230-240.
2017	Khosla S, Hofbauer LC. Osteoporosis treatment: recent developments and ongoing challenges. Lancet Diabetes Endocrinol. November 2017;5(11):898-907.
2015	Einhorn TA, Gerstenfeld LC. Fracture healing: mechanisms and interventions. Nat Rev Rheumatol. 2015;11(1):45-54.
2020	Ohbayashi Y, Iwasaki A, Nakai F, Mashiba T, Miyake M. A comparative effectiveness pilot study of teriparatide for medication-related osteonecrosis of the jaw: daily versus weekly administration. Osteoporos Int. March 2020;31(3):577-585.
2011	Burt LA. Upper Body Bone Strength and Muscle Function in Non-Elite Artistic Gymnasts [PhD thesis]. Australian Catholic University; May 2011.
2015	Scully N. Differentiation of Osteoblasts to Osteocytes in 3D Type I Collagen Gels: A Novel Tool to Study Osteocyte Responses to Mechanical Loading [PhD thesis]. Cardiff, UK: Cardiff University; April 2015.
2010	Lynch ME. Cancellous Bone Adaptation to Non-Invasive Mechanical Loading in the Murine Tibia [PhD thesis]. Ithaca, NY: Cornell University; August 2010.
2015	Brock GR Jr. Changes in Bone Tissue Properties With Osteoporosis Treatment [PhD thesis]. Ithaca, NY: Cornell University; January 2015.
2017	Walk RE. Bone Phenotype of Toll-Like Receptor 5 Deficient (TLR5KO) Mice and PTH Treated Osteopenic Sheep [Master's thesis]. Ithaca, NY: Cornell University; August 2017.
2016	Oei L. Epidemiological, Radiological and Genetic Aspects of Endocrine Bone Diseases [PhD thesis]. Erasmus University Rotterdam; December 14, 2016.
2019	Bakr M. Parathyroid Hormone Effect on Facilitating Stress Fracture Repair [PhD thesis]. Brisbane, Australia: Griffith University; July 2019.
2015	Weatherholt AM. Translational Studies Into the Effects of Exercise on Estimated Bone Strength [PhD thesis]. Indianapolis, IN: Indiana University; September 2015.
2015	Appelman-Dijkstra NM. Long-Term Consequences of Growth Hormone Replacement and Cranial Radiation on Pituitary Function [PhD thesis]. Leiden University; June 4, 2015.
2015	Oftadeh R. Hierarchical Analysis and Multiscale Modelling of Cellular Structures: From Meta Materials to Bone Structure [PhD thesis]. Northeastern University; December 2015.
2020	Simfia I. Estrogen Deficiency Alters the Mechanobiological Responses of Osteoblasts and Osteocytes [PhD thesis]. National University of Ireland Galway; April 2020.
2014	Bradke BS. The Role of Cortical and Cancellous Bone Quality on Vertebral Fragility [PhD thesis]. Troy, NY: Rensselaer Polytechnic Institute; April 2014.
2012	Brennan MA. Close to the Bone: Investigations Into Bone Tissue Mineralisation and Mechanobiology of Osteoporosis [PhD thesis]. University of Southampton; January 2012.
2012	Bassit ACF. Role of IGF-I as a Potential Mediator for the Skeletal Effects of Bone Anabolic Agents [PhD thesis]. University of Florida; August 2012.
2021	Tseng W-J. Structural and Mechanical Responses to Intermittent Parathyroid Hormone Treatment, Discontinuation and Cyclic Administration Regimens [PhD thesis]. Philadelphia, PA: University of Pennsylvania; 2021.
2020	Hiebert B. The Development of a Cortical Bone Turnover Model: Parathyroid Hormone Effects in the Rabbit [Master's thesis]. University of Saskatchewan; July 2020.