Osteoporosis and the replacement of cell populations of the marrow by adipose tissue:​ a quantitative study of 84 iliac bone biopsies

Meunier, P.; Aaron, J.; Edouard, C.; Vignon, G.

Affiliations

¹Laboratoire de Recherches sur l'Histodyna miquc Osseuse, Chaire d'Hydrologie Thérapeutique, Faculté de Médecine, 8 Av, Rockefeller, 69. Lyon (8C), France

²Research Assistant, Mineral Metabolism Unit (Dr. B.E.C. Nordin), General Infirmary, Leeds 1, England

Links

DOI: 10.1097/00003086-197110000-00021

PubMed: 5133320

WoS: A1971K507000021

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Cited By (36)

Year	Entry
1973	Meunier P, Courpron P, Edouard C, Bernard J, Bringuier J, Vignon G. Physiological senile involution and pathological rarefaction of bone: quantitative and comparative histological data. Clin Endocrinol Metab. July 1973;2(2):239-256.
1988	Parfitt AM. Bone remodeling: relationship to the amount and structure of bone, and the pathogenesis and prevention of fractures. In: Riggs BL, Melton LJ III, eds. Osteoporosis: Etiology, Diagnosis, and Management. New York, NY: Raven Press; 1988:45-93.
1983	Jee WS, Wronski TJ, Morey ER, Kimmel DB. Effects of spaceflight on trabecular bone in rats. Am J Physiol Regul Integr Comp Physiol. 1983;244(3):R310-R314.
2001	Justesen J, Stenderup K, Ebbesen EN, Mosekilde L, Steiniche T, Kassem M. Adipocyte tissue volume in bone marrow is increased with aging and in patients with osteoporosis. Biogerontology. September 2001;2(3):165-171.
2007	Bolotin HH. DXA in vivo BMD methodology: an erroneous and misleading research and clinical gauge of bone mineral status, bone fragility, and bone remodelling. Bone. July 2007;41(1):138-154.
2021	Whitney DG, Devlin MJ, Alford AI, Caird MS. Pattern of bone marrow lipid composition measures along the vertebral column: a descriptive study of adolescents with idiopathic scoliosis. Bone. January 2021;142:115702.
2021	Surowiec RK, Ram S, Idiyatullin D, Goulet R, Schlecht SH, Galban CJ, Kozloff KM. In vivo quantitative imaging biomarkers of bone quality and mineral density using multi-band-SWIFT magnetic resonance imaging. Bone. February 2021;143:115615.
2021	Whitney DG, Alford AI, Devlin MJ, Li Y, Caird MS. Intersite reliability of vertebral bone marrow lipidomics-derived lipid composition among children with varying degrees of bone fragility undergoing routine orthopedic surgery. Bone. February 2021;143:115633.
2021	Goel D, Vohora D. Liver X receptors and skeleton: current state-of-knowledge. Bone. March 2021;144:115807.
1983	Mazess RB. Errors in measuring trabecular bone by computed tomography due to marrow and bone composition. Calcif Tiss Int. December 1983;35(2):148-152.
1982	Mazess RB. On aging bone loss. Clin Orthop Relat Res. May 1982;165:239-252.
2007	David V, Martin A, Lafage-Proust M-H, Malaval L, Peyroche S, Jones DB, Vico L, Guignandon A. Mechanical loading down-regulates peroxisome proliferator-activated receptor γ in bone marrow stromal cells and favors osteoblastogenesis at the expense of adipogenesis. Endocrinology. May 2007;148(5):2553-2562.
2010	Manolagas SC. From estrogen-centric to aging and oxidative stress: a revised perspective of the pathogenesis of osteoporosis. Endocr Rev. June 2010;31(3):266-300.
2007	Glatt V, Canalis E, Stadmeyer L, Bouxsein ML. Age‐related changes in trabecular architecture differ in female and male C57BL/6J mice. J Bone Miner Res. August 2007;22(8):1197-1207.
2013	Patsch JM, Li X, Baum T, Yap SP, Karampinos DC, Schwartz AV, Link TM. Bone marrow fat composition as a novel imaging biomarker in postmenopausal women with prevalent fragility fractures. J Bone Miner Res. August 2013;28(8):1721-1728.
2019	Yang M, Arai A, Udagawa N, Zhao L, Nishida D, Murakami K, Hiraga T, Takao-Kawabata R, Matsuo K, Komori T, Kobayashi Y, Takahashi N, Isogai Y, Ishizuya T, Yamaguchi A, Mizoguchi T. Parathyroid hormone shifts cell fate of a leptin receptor‐marked stromal population from adipogenic to osteoblastic lineage. J Bone Miner Res. October 2019;34(10):1952-1963.
2020	McGrath C, Sankaran JS, Misaghian‐Xanthos N, Sen B, Xie Z, Styner MA, Zong X, Rubin J, Styner M. Exercise degrades bone in caloric restriction, despite suppression of marrow adipose tissue (MAT). J Bone Miner Res. January 2020;35(1):106-115.
2005	Yeung DKW, Griffith JF, Antonio GE, Lee FKH, Woo J, Leung PC. Osteoporosis is associated with increased marrow fat content and decreased marrow fat unsaturation: a proton MR spectroscopy study. J Magn Reson Imaging. August 2005;22(2):279-285.
1982	Parfitt AM. The coupling of bone formation to bone resorption: a critical analysis of the concept and of its relevance to the pathogenesis of osteoporosis. Metab Bone Dis Rel Res. 1982;4(1):1-6.
2006	Rosen CJ, Bouxsein ML. Mechanisms of disease: is osteoporosis the obesity of bone? Nat Clin Pract Rheumatol. January 2006;2(1):35-43.
1995	Tran NT, Watson NA, Tencer AF, Ching RP, Anderson PA. Mechanism of the burst fracture in the thoracolumbar spine: the effect of loading rate. Spine. September 15, 1995;20(18):1984-1988.
2012	Shah BS. Pyrintegrin Induced Adipogenesis: Biology, Bioengineering and Therapeutics [PhD thesis]. Columbia University; 2012.
2017	Mathavan N. The Anabolic - Anti-Catabolic Paradigm of Augmenting Skeletal Regeneration: A Bone Quality Perspective [PhD thesis]. Lund, Sweden: Lund University; 2017.
2003	Chan GK. Delineation of Regulatory Factors and Mechanisms That Govern the Differentiation of Mesenchymal Cells to the Osteoblastic Lineage [PhD thesis]. McGill University; June 2003.
2003	Duque G. Molecular Changes in the Aging Osteoblast [PhD thesis]. McGill University; March 2003.
2013	Antolić A. Mitochondrial Contributions to Bone Health, an Investigation Using Two Different Animal Models of Mitochondrial Capacity [PhD thesis]. Hamilton, ON: McMaster University; September 2013.
2019	Piet J. Restoring Mechano-Adaptation in Aged Murine Bone [PhD thesis]. Northeastern University; March 2019.
2017	Keune JA. The Role of Bone Marrow Adipose Tissue in Bone Loss During Spaceflight and Simulated Spaceflight in Rodents [PhD thesis]. Oregon State University; 2017.
2010	Trinward A. Osteoporosis Drugs Prevent Bone Loss, Normalize Metabolic Parameters and Negatively Correlate Bone and Fat [Master's thesis]. Stony Brook, NY: Stony Brook University; 2010.
2011	Appiah-Nkansah K. Integration of Refractory Periods in the Administration of Low-Magnitude Mechanical Signals Increases Mesenchymal Stem Cell Numbers in the Bone Marrow [Master's thesis]. Stony Brook, NY: Stony Brook University; May 2011.
2018	Patel VS. Harnessing Cell Mechanosensitivity to Combat Obesity-Induced Systemic Metabolic Disruptions and to Promote Protein Production for Bioprocessing [PhD thesis]. Stony Brook, NY: Stony Brook University; December 2018.
2017	Whitney DG. Obesity Indices in Children With Spastic Cerebral Palsy [PhD thesis]. University of Delaware; 2017.
2007	Ackert-Bicknell CL. The Effects of Allelic Variation in Pparg* on Skeletal Metabolism* [PhD thesis]. Orono, ME: University of Maine; December 2007.
2019	Surowiec R. Novel Models to Image and Quantify Bone Drug Efficacy and Disease Progression in Vivo: Addressing the Fragility Phenotype [PhD thesis]. University of Michigan; 2019.
2010	Hughes JM. Revisiting Harold Frost's Mechanostat Theory of Bone Functional Adaptation: New Interpretations Based on New Evidence [PhD thesis]. University of Minnesota; December 2010.
2015	Ng AH-M. A Mouse Model of Adynamic Bone Disease (ABD) and Its Consequences on Bone Quality With Age [PhD thesis]. University of Toronto; 2015.