Mechanisms of disease: is osteoporosis the obesity of bone?

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Rosen, Clifford J.^1,2; Bouxsein, Mary L.³

Mechanisms of disease: is osteoporosis the obesity of bone?

Nat Clin Pract Rheumatol. January 2006;2(1):35-43

©2006 Nature Publishing Group

Affiliations

¹The Jackson Laboratory in Bar Harbor, ME, USA

²Maine Center for Osteoporosis Research, Bangor, ME, USA

³Harvard Medical School and the Beth Israel Deaconess Medical Center in Boston, MA, USA
Abstract and keywords

Osteoporosis and obesity, two disorders of body composition, are growing in prevalence. Interestingly, these diseases share several features including a genetic predisposition and a common progenitor cell. With aging, the composition of bone marrow shifts to favor the presence of adipocytes, osteoclast activity increases, and osteoblast function declines, resulting in osteoporosis. Secondary causes of osteoporosis, including diabetes mellitus, glucocorticoids and immobility, are associated with bone-marrow adiposity. In this review, we ask a provocative question: does fat infiltration in the bone marrow cause low bone mass or is it a result of bone loss? Unraveling the interface between bone and fat at a molecular and cellular level is likely to lead to a better understanding of several diseases, and to the development of drugs for both osteoporosis and obesity.

Keywords: adipocyte; bone; fat; obesity; osteoporosis
Links

DOI: 10.1038/ncprheum0070

PubMed: 16932650

WoS: 000235165500005
History

Received: 2005-08-10

Accepted: 2005-09-29

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