Fatigue of immature baboon cortical bone

Keller, T. S.<sup>1</sup>; Lovin, J. D.<sup>2</sup>; Spengler, D. M.<sup>3</sup>; Carter, D. R.<sup>4</sup>

Affiliations

¹Orthopaedic Research Laboratory. V. A. Medical Center, Nashville. TN 37203, U.S.A.

²University of Washington, School of Medicine, Seattle. WA 98195, U.S.A.

³Department of Orthopaedics and Rehabilitation, Vanderbilt Medical Center North, Nashville, TN 37232, U.S.A.

⁴Department of Mechanical Engineering, Stanford University, Stanford, CA 94305, U.S.A.

Abstract

Strain-controlled uniaxial fatigue and monotonic tensile tests were conducted on turned femoral cortical bone specimens obtained from baboons at various ages of maturity. Fatigue loading produced a progressive loss in stiffness and an increase in hysteresis prior to failure, indicating that immature primate cortical bone responds to repeated loading in a fashion similar to that previously observed for adult human cortical bone. Bone fatigue resistance under this strain controlled testing decreased during maturation. Maturation was also associated with an increase in bone dry density, ash fraction and elastic modulus. The higher elastic modulus of more mature bone meant that these specimens were subjected to higher stress levels during testing than more immature bone specimens. Anatomical regions along the femoral shaft exhibited differences in strength and fatigue resistance.

Links

DOI: 10.1016/0021-9290(85)90847-4

PubMed: 4019527

WoS: A1985AKC4600006

History

Received: 1984-05

Revised: 1984-11

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Cited By (16)

Year	Entry
1989	Schaffler MB, Radin EL, Burr DB. Mechanical and morphological effects of strain rate on fatigue of compact bone. Bone. 1989;10(3):207-214.
1990	Schaffler MB, Radin EL, Burr DB. Long-term fatigue behavior of compact bone at low strain magnitude and rate. Bone. 1990;11(5):321-326.
1989	Forwood MR, Parker AW. Microdamage in response to repetitive torsional loading in the rat tibia. Calcif Tiss Int. July 1989;45(1):47-53.
1989	Jones BH, Harris JM, Vinh TN, Rubin C. Exercise-induced stress fractures and stress reactions of bone: epidemiology, etiology, and classification. Exerc Sport Sci Rev. January 1989;17(1):379-422.
1997	Burr DB. Bone, exercise, and stress fractures. Exerc Sport Sci Rev. January 1997;25(1):171-194.
1989	Keller TS, Spengler DM. Regulation of bone stress and strain in the immature and mature rat femur. J Biomech. 1989;22(11-12):1115-1127.
1992	Choi K, Goldstein SA. A comparison of the fatigue behavior of human trabecular and cortical bone tissue. J Biomech. 1992;25(12):1371-1381.
1994	Keller TS. Predicting the compressive mechanical behavior of bone. J Biomech. September 1994;27(9):1159-1168.
2008	Kosmopoulos V, Schizas C, Keller TS. Modeling the onset and propagation of trabecular bone microdamage during low-cycle fatigue. J Biomech. 2008;41(3):515-522.
1986	Keller TS, Spengler DM, Carter DR. Geometric, elastic, and structural properties of maturing rat femora. J Orthop Res. 1986;4(1):57-67.
1990	Brear K, Currey JD, Pond CM. Ontogenetic changes in the mechanical properties of the femur of the polar bear Ursus maritimus. J Zool. 1990;222(1):49-58.
1994	Finlay JB, Hardie WR. Anisotropic contraction of cortical bone caused by dehydration of samples of the bovine femur in vitro. Proc Inst Mech Eng Part H-J Eng Med. 1994;208(1):27-32.
1993	Guo X-DE. Fatigue of Trabecular Bone [PhD thesis]. Cambridge, MA: Harvard University; 1993.
1987	Stover SM. Dorsal Metacarpal Disease in Thoroughbred Horses: Relationship to the Development of the Third Metacarpal Bone [PhD thesis]. Davis, University of California; 1987.
1991	Choi K. The Micro Mechanical Properties of Bone Tissue [PhD thesis]. University of Michigan; 1991.
1985	Schaffler MB. Stiffness and Fatigue of Compact Bone At Physiological Strains and Strain Rates [PhD thesis]. Morgantown, WV: West Virginia University; 1985.