The purpose of this study was to evaluate the relationship between HIC and BrIC and injury metrics for real world intraparenchymal head injury in motor vehicle crashes (MVCs). Geometric and anatomically defined injury metrics were developed to study contusion, intraparenchymal hemorrhage, intraventricular hemorrhage, and DAI. The anatomically defined regions of interest included the fronto-temporal region, thalamus, corpus callosum, brain elements surrounding the ventricles, and a sphere of deep brain tissue. Geometrically defined regions of interest were developed based on impact location and were used to evaluate coup and contre-coup regions. 1,080 head impact simulations were conducted using the GHBMC 50th percentile finite element head and neck by varying impact direction, speed, location, and contact stiffness. Maximum principal strain, maximum shear strain, maximum pressure, and minimum pressure in each element was calculated for each simulation and correlations to HIC and BrIC were assessed. Positive pressures in the coup region were better correlated with HIC than BrIC (R² = 0.56 and R² = 0.35, respectively). Shear strain in the elements surrounding the ventricles was higher for off-axis loading compared to linear impacts (p<0.001). The average 50th percentile maximum shear strain in the corpus callosum (DAI) was better correlated with BrIC than HIC (R² = 0.82 and R² = 0.46, respectively) in soft and compliant impacts. Many of the strain measurements in the deep brain (Intraparenchymal hemorrhage, DAI) were unaffected by a change of impactor stiffness between compliant and hard. These data lend support to the continued discussion of efficacy of HIC and BrIC for the use of predicting head injury in MVCs.