The TNO Road-Vehicles Research Institute is involved in a long-term research programme on pedestrian and cyclist safety. Until now 45 full-scale dummy and cadaver tests with simulated vehicle fronts and real passengecr ars have been performed. Part of the programme is presented in this paper. Cyclist impacts with real passenger cars are compared with cyclist impacts with simulated vehicle fronts. Also comparisons are made between tests with cyclist-dummies and tests with cyclist-cadavers. Special attention is given to the influence of the initial bicycle speed. The results of these experimental simulations are compared with the results obtained from 3D mathematical model simulations conducted with the MADYMO CVS package. Recommendations are made with respect to future regulations in this field.