The paper presents an analytical methodology for studying a class of cycle-to-vehicle collisions and reports on a successful full-scale impact test utilizing a modified crash test dummy for the motorcycle rider. The laws of mechanics are applied in a straight-forward manner to predict the dynamics of a motorcycle oblique (glancing) impact to the front of a flat-faced car. An analysis of loading of the cyclist's near-side lower leg as the side of the cycle impinges on the front of the car is performed. The application of biomechanical data on tibial bone strength enables prediction of expected injury. A fullscale impact test is described where a 350 cc motorcycle impacts a generic car under the same conditions assumed for the analytical study. The cyclist was a Part 572 50th percentile anthropomorphic dummy fitted with a specially-developed frangible lower leg having biomechanical fidelity of strength in bending. Data presented include calculated leg loads and illustrative photos depicting the full-scale test. Cycle kinematics and lower leg injury analytically predicted and experimentally observed were found to correlate well.