Effect of mineral–collagen interfacial behavior on the microdamage progression in bone using a probabilistic cohesive finite element model

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Luo, Qing^1,2; Nakade, Rugved²; Dong, Xuanliang³; Rong, Qiguo¹; Wang, Xiaodu²

Effect of mineral–collagen interfacial behavior on the microdamage progression in bone using a probabilistic cohesive finite element model

J Mech Behav Biomed Mater. October 2011;4(7):943-952

Affiliations

¹Biomedical Engineering, Peking University, Beijing 100871, China

²Mechanical Engineering, The University of Texas at San Antonio, One UTSA Circle, San Antonio, TX 78249, USA

³Health and Kinesiology, The University of Texas at Tyler, USA
Abstract and keywords

The interactions between mineral and collagen phases in the ultrastructural level play an important role in determining the mechanical properties of bone tissue. Three types of mineral–collagen interaction (i.e., ionic interactions, hydrogen/van der Waals bonds, and van der Waals/viscous shear in opening/sliding mode, respectively) have been simulated in this study, using cohesive zone-modeling techniques. Considering the inhomogeneity of bone, a probabilistic failure analysis approach has been also employed to account for the effect of mineral–collagen interfacial behavior on microdamage accumulation in lamellar bone tissues. The results of this study suggested that different interfacial behaviors cause different types of microdamage accumulation. The ionic interactions between the mineral and collagen phases lead to the formation of linear microcracks, while the van der Waals/viscous shear interactions may facilitate the formation of diffuse damage. In the case of hydrogen/van der Waals bonds, a transitional behavior of microdamage accumulation in bone was observed. The findings of this study may help in understanding the mechanisms of mineral–collagen interactions and its effects on the failure mechanism of bone.

Keywords: Bone; Mineral–collagen interface; FEM; Cohesive element; Probabilistic failure analysis; Microdamage
Links

DOI: 10.1016/j.jmbbm.2011.02.003

PubMed: 21783104

WoS: 000294187500004
History

Received: 2010-12-3

Revised: 2011-02-3

Accepted: 2011-02-6

Online: 2011-02-16

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