The role of water and mineral–collagen interfacial bonding on microdamage progression in bone

Luo, Qing; Leng, Huijie; Wang, Xiaodu; Zhou, Yanheng; Rong, Qiguo

Affiliations

¹College of Engineering, Peking University, Beijing, China

²Department of Orthodontics, Peking University School and Hospital of Stomatology, Beijing, China

³Department of Orthopaedics, Peking University Third Hospital, Beijing, China

⁴Department of Mechanical Engineering, The University of Texas at San Antonio, San Antonio, TX 78249

Abstract and keywords

Microdamage would be accumulated in bone due to high-intensity training or even normal daily activity, which may consequently cause fragility fracture or stress fracture. On the other hand, microdamage formation serves as a toughening mechanism in bone. However, the mechanisms that control microdamage initiation and accumulation in bone are still poorly understood. Our previous finite element model indicated that different interfacial properties between mineral and collagen in bone may lead to distinct patterns of microdamage accumulation. Therefore, the current study was designed to examine such prediction and to investigate the role of water and mineral–collagen interactions on microdamage accumulation in bone. To address these issues, 48 mice femurs were divided randomly into four groups. These groups were dehydrated or treated with perfluorotripropylamine (PFTA) or NaF solution to change water distribution and mineral–collagen interfacial bonding in bone. After three-point bending fatigue tests, the types of microdamage (i.e., linear microcracks or diffuse damage) formed in bone were compared between different groups. The results suggested that (1) bone tissues with strong mineral–collagen interfacial bonding facilitate the formation of linear microcraks, and (2) water has little contribution to the growth of microcracks.

Keywords: bone;microdamage progression;mineral–collagen interaction mechanisms;water

Links

DOI: 10.1002/jor.22501

PubMed: 24122969

WoS: 000328315100007

History

Received: 2012-11-12

Accepted: 2013-09-17

Online: 2013-10-10

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Cited By (1)

Year	Entry
2017	Unal M. Classification of Bound Water and Collagen Denaturation Status of Cortical Bone by Raman Spectroscopy [PhD thesis]. Cleveland, OH: Case Western Reserve University; January 2017.