Effect of Hydrogen Bonding Ability, Dipole-Dipole Interactions and Viscosity of Extracellular Matrix Fluid on the Bone Mechanical Behavior

This is an exploratory study to determine the role of water in sustaining the mechanical behavior of bone. Water is speculated to interact in two different ways with the mineral and collagen phases; namely, hydrogen bonding and dipole-dipole interactions. This study followed an experimental procedure of replacing water present in bone with different fluids of known hydrogen bonding abilities and polarities to identify effect of Hydrogen bonding and polarity of extracellular matrix fluid on the mechanical behavior of bone. After replacement of the extracellular matrix fluid with selected solvents, mechanical testing was done using a progressive loading protocol to determine the effect changing the hydrogen bonding ability and polarity of the matrix fluid on the mechanical behavior of bone. Further data processing to quantify the various parameters measuring different mechanical properties was done followed by statistical analysis to determine if there were any significant changes in the mechanical behavior of bone when the extracellular matrix fluid was replaced by other solvents.

The experimental results indicated that there are significant changes in the bone mechanical behavior when the extracellular matrix fluid is replaced with different solvents

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Year

Entry

1985

Gibson LJ. The mechanical behaviour of cancellous bone. J Biomech. 1985;18(5):317-328.

2003

Kruzic JJ, Nalla RK, Kinney JH, Ritchie RO. Crack blunting, crack bridging and resistance-curve fracture mechanics in dentin: effect of hydration. Biomaterials. 2003;24(28):5209-5221.

1996

Landis WJ, Hodgens KJ, Arena J, Song MJ, McEwen BF. Structural relations between collagen and mineral in bone as determined by high voltage electron microscopic tomography. Microsc Res Tech. 1996;33(2):192-202.

2008

Nyman JS, Ni Q, Nicolella DP, Wang X. Measurements of mobile and bound water by nuclear magnetic resonance correlate with mechanical properties of bone. Bone. January 2008;42(1):193-199.

2006

Nyman JS, Roy A, Shen X, Acuna RL, Tyler JH, Wang X. The influence of water removal on the strength and toughness of cortical bone. J Biomech. 2006;39(5):931-938.